Sex differences in impact of cumulative systolic blood pressure from childhood to adulthood on albuminuria in midlife: a 30-year prospective cohort study

Table 2 Association of SBP total AUC groups with midlife albuminuria by sex

Characteristics	N (%)	Unadjusted		Model 1		Model 2
Characteristics	N (%)	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	P*
Total subjects								< 0.001
Low	43 (7.7%)	1.00	-	1.00	-	1.00
Middle	58 (10.3%)	1.39 (0.92–2.10)	0.119	1.39 (0.89–2.16)	0.145	1.30 (0.82–2.06)	0.261
High	89 (15.9%)	2.27 (1.55–3.33)	< 0.001^#	1.92 (1.18–3.11)	0.008^#	1.92 (1.18–3.15)	0.009^#
Male Subjects
Low	16 (7.4%)	1.00	-	1.00	-	1.00	-
Middle	26 (8.1%)	1.11 (0.58–2.11)	0.762	1.08 (0.54–2.12)	0.835	1.17 (0.56–2.46)	0.672
High	59 (13.3%)	1.93 (1.08–3.43)	0.026^#	1.28 (0.66–2.51)	0.465	1.57 (0.77–3.23)	0.218
Female Subjects
Low	27 (7.8%)	1.00	-	1.00	-	1.00	-
Middle	32 (13.3%)	1.80 (1.05–3.10)	0.033	1.65 (0.91–3.98)	0.097	1.50 (0.82–2.76)	0.188
High	30 (33.7%)	3.97 (2.24–7.02)	< 0.001^#	2.95 (1.47–5.93)	0.002^#	2.68 (1.30–5.53)	0.007^#

Model 1: adjusted for age, gender, systolic blood pressure, body mass index at baseline, body mass index, waist, hips, smoking, alcohol consumption, exercise, and history of hypertension, diabetes, hyperlipidaemia in 2017.
Model 2: adjusted for model 1 + fasting blood glucose, ALT, AST, total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, serum uric acid and serum creatinine.
P*: p value for interaction terms of total AUC and sex.
^#: p value was considered significant after false discovery rate correction.

ISSN: 1471-2458