Comparison of healthspan-related indicators between adults with and without HIV infection aged 18–59 in the United States: a secondary analysis of NAHNES 1999–March 2020

Table 2 Adjusted prevalences and population estimates of health outcomes in the United States 1999-March 2020, by HIV infection status

Outcomes		Persons with HIV			Persons without HIV		Prevalence Difference, % (95%CI)	P-Value^*
Outcomes	n/N^a	Prevalence^b, % (95%CI)	Estimated Population^c	n/N^a	Prevalence^b, % (95%CI)	Estimated Population^c
Physical Frailty	50/170	28.9 (28.8, 29.0)	330 147	3 705/32 878	10.4 (10.4, 10.4)	28 419 884	18.5 (18.4, 18.6)	< 0.001
ADL Disability	36/70	59.7 (59.5, 60.0)	246 540	2 014/5 127	36.3 (36.3, 36.3)	16 514 816	23.4 (23.2, 23.7)	< 0.001
Mobility Disability	59/70	84.3 (84.0, 84.5)	392 823	3 689/5 127	69.8 (69.7, 69.8)	31 757 450	14.5 (14.2, 14.8)	< 0.001
Depression	52/122	41.9 (41.7, 42.0)	414 507	5 725/24 167	22.4 (22.4, 22.4)	47 676 267	19.5 (19.3, 19.6)	< 0.001
Multimorbidity	43/170	18.9 (18.8, 19.0)	280 525	3 619/22 030	12.0 (12.0, 12.0)	32 465 944	6.9 (6.8, 7.0)	< 0.001
All-cause Death	29/170	17.4 (17.4, 17.5)	179 588	961/32 968	2.7 (2.7, 2.7)	7 443 135	14.7 (14.6, 14.8)	< 0.001

Abbreviations: CI 95% confidence interval, ADL activities of daily living
^aNumber for both numerator and denominator were based on unweighted study samples
^bPrevalence, % and (95% CI) were calculated by marginal structural models using an inverse-probability-of-exposure weight adjusted for age, sex, ethnicity and education
^cRefers to weighted number of n case, which were calculated from weighted estimates, eg., 50 represented 330,147 population with HIV suffered with physical frailty, 3,705 represented 28,419,884 population without HIV suffered with physical frailty; Weighted numbers of N population were also calculated, eg., 170 represented 1,184,357 population with HIV, 32,878 represented 273,794,954 US adults
^*P value was obtained from the marginal structural model method (see in the Analyses section) between with HIV vs. without HIV

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