Table 1 The incident cases and ASIR of syphilis in 1990 and 2019, and its temporal trends from 1990 to 2019

Overall

8845.22(6562.51, 11588.86)

160.03(120.66, 208.1)

14114.11(10648.49, 18415.97)

178.48(134.94, 232.34)

0.16(0.07, 0.26)

Sex

 Female

3355446.35(2502207.45, 4388063.8)

119.95(90.17, 156.34)

4824855.31(3725828.82, 6182484.11)

124.98(96.68, 160.25)

-0.3(-0.49, -0.11)

 Male

5489771.19(4066355.47, 7208417.29)

199.14(149.81, 260.75)

9289253.08(6919196.33, 12282791.68)

231.31(171.88, 305.3)

0.43(0.38, 0.47)

Socio-demographic index

 High SDI

623.3(471.9, 826.55)

71.52(54.07, 94.72)

721.92(548.59, 951.88)

74.05(55.61, 98.92)

0.16(0.1, 0.22)

 High-middle SDI

1011.91(754.28, 1333.58)

82.22(61.68, 108.01)

1356.68(1033.5, 1786.05)

91.55(69.25, 119.03)

0.11(0.01, 0.21)

 Middle SDI

2477.83(1809.89, 3280.76)

136.26(102.1, 179.16)

3472.41(2596.1, 4596.48)

136.36(101.06, 180.12)

-0.18(-0.3, -0.06)

 Low-middle SDI

2459.57(1804.25, 3253.48)

224.35(166.26, 294.69)

4169.24(3092.78, 5465.2)

221.41(165.71, 289.75)

-0.27(-0.39, -0.15)

 Low SDI

2267.02(1720.58, 2889.82)

467.4(356.95, 593.73)

4384.62(3345.66, 5637.48)

398.05(306.64, 507.71)

-0.74(-0.8, -0.67)

Region

 Andean Latin America

83.04(61.3, 110.51)

221.73(167.05, 293.67)

138.14(104.7, 180.53)

207.84(158.51, 270.68)

-0.45(-0.54, -0.36)

 Australasia

14.1(10.46, 18.96)

65.58(48.71, 87.54)

17.71(13.32, 23.46)

64.07(47.75, 85.84)

-0.12(-0.13, -0.1)

 Caribbean

61.44(45.7, 81.46)

165.87(125.65, 216.09)

92.37(75.16, 113.65)

191.99(156.21, 235.61)

0.49(0.43, 0.55)

 Central Asia

37.39(28.05, 49.21)

54.85(41.88, 71.72)

51.63(39.5, 66.88)

52.1(40.26, 67.34)

-0.36(-0.42, -0.3)

 Central Europe

54.15(41.35, 71.11)

43.38(32.95, 56.96)

47.32(36.32, 61.63)

43.28(32.96, 56.54)

-0.02(-0.04, 0.01)

 Central Latin America

195.78(143.3, 259.92)

118.92(89.05, 156.63)

296.13(227.21, 384.26)

111.77(86.08, 145.02)

-0.27(-0.33, -0.22)

 Central Sub-Saharan Africa

580.89(435.01, 749.57)

1153.28(880.53, 1482.29)

1332.45(1017.53, 1723.69)

1048.4(803.52, 1344.82)

-0.5(-0.58, -0.41)

 East Asia

1224.26(895.45, 1631.22)

89.28(66.65, 118.27)

1459.54(1092.02, 1958.96)

93.43(69.27, 123.92)

-0.08(-0.21, 0.04)

 Eastern Europe

125.74(96.17, 165.15)

53.1(40.9, 68.98)

102.35(78.85, 136.35)

47.97(37.05, 62.56)

-0.56(-0.65, -0.48)

 Eastern Sub-Saharan Africa

1181.6(916.25, 1480.69)

669.08(522.83, 834.07)

1992.07(1551.25, 2495.06)

492.63(386.33, 619.27)

-1.42(-1.61, -1.23)

 High-income Asia Pacific

145.87(110.95, 192.31)

78.31(59.18, 103.74)

136.11(103.15, 181.01)

81.36(60.92, 109.14)

0.28(0.22, 0.34)

 High-income North America

205.18(154.8, 273.09)

68.27(51.74, 89.69)

252.31(192.72, 331.6)

71.76(54.06, 95.06)

0.18(-0.03, 0.39)

 North Africa and Middle East

262.02(189.03, 348.87)

79.67(59.21, 106.06)

562.03(415.47, 750.43)

84.2(62.65, 111.7)

0.15(0.06, 0.24)

 Oceania

28.67(20.98, 37.65)

430.43(320.8, 560.81)

57.91(42.04, 76.97)

415.8(301.62, 551.31)

-0.56(-0.73, -0.38)

 South Asia

2332.44(1691.29, 3098.81)

219.04(161.13, 289.42)

3725.19(2730.12, 4965.9)

190.99(140.95, 254.13)

-0.71(-0.95, -0.47)

 Southeast Asia

487.64(352.37, 649.91)

101.17(74.45, 134.79)

722.67(535.24, 961.37)

99.61(73.45, 131.74)

-0.14(-0.19, -0.1)

 Southern Latin America

58.65(43.84, 77.44)

117.88(88.25, 155.84)

88.79(71.68, 110.38)

131.89(106.8, 163.69)

0.26(0.08, 0.44)

 Southern Sub-Saharan Africa

502.74(381.66, 648.48)

916.8(697.82, 1174.15)

571.16(420.69, 751.87)

665.35(496.08, 872.21)

-1.19(-1.69, -0.69)

 Tropical Latin America

190.64(139.63, 255.94)

119.04(88.38, 158.58)

332.79(259.02, 415.93)

139.68(109.18, 174.26)

-0.66(-1.5, 0.17)

 Western Europe

269.53(201.47, 355.93)

68.34(51.17, 90.38)

263(199.22, 348.2)

67.63(50.12, 90.19)

-0.03(-0.04, -0.02)

 Western Sub-Saharan Africa

803.45(591.41, 1043.07)

461.93(345.94, 598.09)

1872.43(1377.02, 2458.53)

427.97(318.21, 556.32)

-0.26(-0.31, -0.2)