Table 3 HRs and 95% CIs of incident eGFR decline ≥ 40% according to tertiles of FPG variability measures in Tehran Lipid and Glucose Study
Variability measures | Model 1 | Model 2 | Model 3 | Model 4 |
|---|---|---|---|---|
HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
With diabetes | ||||
SD | ||||
 T1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
 T2 | 1.20 (0.69–2.10) | 1.06 (0.59–1.90) | 0.93 (0.53–1.66) | 0.88 (0.49–1.58) |
 T3 | 0.98 (0.54–1.77) | 0.76 (0.39–1.47) | 0.77 (0.42–1.44) | 0.67 (0.33–1.33) |
 P trend | 0.968 | 0.414 | 0.417 | 0.254 |
CV | ||||
 T1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
 T2 | 1.04 (0.60–1.82) | 0.96 (0.53–1.73) | 0.80 (0.44–1.43) | 0.77 (0.42–1.39) |
 T3 | 0.94 (0.53–1.66) | 0.74 (0.40–1.37) | 0.74 (0.41–0.34) | 0.70 (0.38–1.29) |
 P trend | 0.828 | 0.332 | 0.327 | 0.253 |
ARV | ||||
 T1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
 T2 | 1.47 (0.84–2.58) | 1.29 (0.71–2.33) | 0.99 (0.55–1.79) | 0.94 (0.52–1.72) |
 T3 | 1.09 (0.60–2.01) | 0.84 (0.43–1.65) | 0.83 (0.44–1.55) | 0.71 (0.35–1.44) |
 P trend | 0.749 | 0.588 | 0.539 | 0.344 |
VIM | ||||
 T1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
 T2 | 1.10 (0.63–1.92) | 1.18 (0.67–2.09) | 1.09 (0.62–1.92) | 1.10 (0.62–1.93) |
 T3 | 0.94 (0.53–1.66) | 0.84 (0.46–1.51) | 0.82 (0.46–1.47) | 0.83 (0.46–1.49) |
 P trend | 0.835 | 0.577 | 0.512 | 0.746 |
Without diabetes | ||||
SD | ||||
 T1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
 T2 | 1.28 (0.80–2.07) | 1.37 (0.84–2.21) | 1.32 (0.81–2.13) | 1.31 (0.81–2.12) |
 T3 | 1.61 (1.02–2.53) | 1.67 (1.05–2.64) | 1.61 (1.02–2.55) | 1.60 (1.01–2.54) |
 P trend | 0.039 | 0.029 | 0.041 | 0.047 |
CV | ||||
 T1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
 T2 | 1.36 (0.85–2.18) | 1.43 (0.89–2.30) | 1.43 (0.90–2.31) | 1.44 (0.89–2.30) |
 T3 | 1.53 (0.97–2.42) | 1.56 (0.98–2.48) | 1.55 (0.98–2.47) | 1.55 (0.97–2.46) |
 P trend | 0.071 | 0.064 | 0.065 | 0.068 |
ARV | ||||
 T1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
 T2 | 1.08 (0.68–1.70) | 1.18 (0.74–1.88) | 1.21 (0.76–1.93) | 1.21 (0.76–1.92) |
 T3 | 1.27 (0.82–1.96) | 1.38 (0.89–2.15) | 1.30 (0.84–2.01) | 1.28 (0.82–1.99) |
 P trend | 0.286 | 0.147 | 0.242 | 0.272 |
VIM | ||||
 T1 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
 T2 | 1.42 (0.88–2.28) | 1.49 (0.93–2.41) | 1.49 (0.93- 2.39) | 1.49 (0.92–2.40) |
 T3 | 1.65 (1.04–2.62) | 1.66 (1.04–2.67) | 1.69 (1.06–2.69) | 1.69(1.06–2.69) |
 P trend | 0.034 | 0.035 | 0.029 | 0.029 |