Table 3 AOM IRs and AOM IRRs for IR change from the pre-PCV7 period, before and after the introduction of PCV7 and PCV13
From: Incidence of acute otitis media from 2003 to 2019 in children ≤ 17 years in England
N episodes | Rate per 100,000 PY (95% CI) | IRRa (95% CI) vs. reference period (pre-PCV7)b | |
|---|---|---|---|
Pre-PCV7 (2003–2005) | |||
Overall (all age-groups) | 66,438 | 4451.9 (4418.1–4485.9) | 1 |
<2 years | 12,328 | 9968.1 (9792.9–10,145.6) | 1 |
2–4 years | 23,334 | 9684.5 (9560.7–9809.6) | 1 |
5–17 years | 30,776 | 2729.0 (2698.6–2759.7) | 1 |
Post-PCV7 (2007–2009) | |||
Overall (all age-groups) | 64,987 | 3879.2 (3849.4–3909.1) | 0.87 (0.85–0.89) |
< 2 years | 13,259 | 8754.5 (8606.1–8904.8) | 0.87 (0.82–0.93) |
2–4 years | 23,307 | 8267.4 (8161.6–8374.2) | 0.80 (0.77–0.83) |
5–17 years | 28,421 | 2288.5 (2262.0–2315.2) | 0.82 (0.79–0.85) |
Early Post-PCV13 (2011–2014) | |||
Overall (all age-groups) | 70,127 | 3462.8 (3437.2–3488.5) | 0.88 (0.86–0.91) |
< 2 years | 13,833 | 7561.5 (7436.0–7688.6) | 0.84 (0.79–0.89) |
2–4 years | 26,143 | 7365.2 (7276.2–7455.1) | 0.87 (0.83–0.90) |
5–17 years | 30,151 | 2027.3 (2004.5–2050.3) | 0.84 (0.81–0.87) |
Late Post-PCV13 (2015–2019) | |||
Overall (all age-groups) | 30,187 | 2658.5 (2628.6–2688.7) | 0.75 (0.73–0.78) |
< 2 years | 6039 | 6491.8 (6329.1–6657.6) | 0.72 (0.67–0.77) |
2–4 years | 11,388 | 5980.9 (5871.6–6091.8) | 0.72 (0.69–0.75) |
5–17 years | 12,760 | 1497.6 (1471.7–1523.8) | 0.68 (0.65–0.71) |