Study protocol of the sweet tooth study, randomized controlled trial with partial food provision on the effect of low, regular and high dietary sweetness exposure on sweetness preferences in Dutch adults

Table 4 Overview of Sweet Tooth outcome measures and data collection methods

Domain	Outcome to Be Measured	Data Collection Method	Baseline	Intervention			Follow-up
Domain	Outcome to Be Measured	Data Collection Method	Baseline	1Month	3 Months	6 Months	7 Months	10 Months
Food taste preference	Sweetness preferences	Rank-rating scale	✓	✓	✓	✓	✓	✓
Food taste preference	Saltiness preferences	Rank-rating scale	✓	✓	✓	✓	✓	✓
Taste intensity perception	Sweet taste perception	100-unit VAS	✓	✓	✓	✓	✓	✓
Taste intensity perception	Salt taste perception	100-unit VAS	✓	✓	✓	✓	✓	✓
Behavioural outcomes	Food choice	Food choice from a buffet	✓	✓	✓	✓	✓	✓
	Food intake	Amount consumed from a buffet	✓	✓	✓	✓	✓	✓
	Sweet-liker type [54]	100-point VAS	✓	✓	✓	✓	✓	✓
	Taste preferences	PrefQuest^a	✓	✓	✓	✓	✓	✓
	Food cravings	CoEQ	✓	✓	✓	✓	✓	✓
	Dietary taste patterns	Taste FFQ^b	✓	✓	✓	✓	✓	✓
Anthropometric outcomes	Body composition	DEXA	✓			✓		✓
	Waist-hip circumference	Measuring tape	✓	✓	✓	✓	✓	✓
	Weight	Digital scale	✓	✓	✓	✓	✓	✓
Biochemical outcomes	Biomarkers related to CVD and diabetes	Fasting blood sample	✓	✓	✓	✓	✓	✓
Biochemical outcomes	Glucose homeostasis	Glucose sensor^c	✓			✓		✓
Compliance	Biomarkers of compliance	Urine sample (24-h sample)	✓	✓	✓	✓	✓	✓
Compliance	Dietary intake	Online 24-h recall	✓	✓	✓	✓	✓	✓
Intervention Moderators	Physical activity	SQUASH	✓	✓	✓	✓	✓	✓
Intervention Moderators	Adverse events, medication use	Questionnaires^b, Study diet diary	✓	✓	✓	✓	✓	✓

CoEQ Control of eating questionnaire [61], CVD Cardiovascular disease, DEXA Dual-energy x-ray absorptiometry, SQUASH Short questionnaire to assess health enhancing physical activity [62], VAS Visual analogue scale
^aTranslated and Modified for the Dutch population based on Deglaire et al., 2012 [63]
^bDeveloped for the Sweet tooth study based on methodology of Diewertje et al., 2016 [64]
^cOnly in a sub-set of participants (n = 60)

ISSN: 1471-2458