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Table 3 Unadjusted and adjusted hazard ratio estimates of overdose death by substance use type (Cox proportional hazards model) (Nā€‰=ā€‰7275).

From: Concurrent use of opioids and stimulants and risk of fatal overdose: A cohort study

Ā 

Unadjusted Estimates

Adjusted Estimate

HR (95%CI)

P-value

HR (95%CI)

P-value

Substance use type

ā€ƒBoth

1Ā·94 (1Ā·45-2Ā·61)

<ā€‰0Ā·001

2Ā·02 (1Ā·47-2Ā·78)

<ā€‰0Ā·001

ā€ƒStimulant

0Ā·99 (0Ā·72-1Ā·35)

0Ā·9322

1Ā·05(0Ā·75-1Ā·48)

0Ā·7644

ā€ƒOpioid

Reference

Sex-Female

0Ā·54 (0Ā·41-0Ā·70)

<ā€‰0Ā·001

0Ā·53 (0Ā·40-0Ā·69)

<ā€‰0Ā·001

Age

ā€ƒā€‰<ā€‰30

0Ā·92 (0Ā·67-1Ā·28)

0Ā·6249

1Ā·07 (0Ā·75-1Ā·52)

0Ā·7112

ā€ƒ30-39

0Ā·68(0Ā·48-0Ā·96)

0Ā·0305

0Ā·74(0Ā·51-1Ā·06)

0Ā·0974

ā€ƒ40-49

1Ā·07(0Ā·77-1Ā·48)

0Ā·6988

1Ā·08(0Ā·78-1Ā·51)

0Ā·6335

ā€ƒ50+

Reference

Health Authority

ā€ƒFraser

0Ā·68 (0Ā·50-0Ā·92)

0Ā·0117

0Ā·79 (0Ā·58-1Ā·07)

0Ā·1270

ā€ƒInterior

0Ā·85(0Ā·60-1Ā·20)

0Ā·3479

1Ā·01(0Ā·71-1Ā·44)

0Ā·9440

ā€ƒNorthern

0Ā·56(0Ā·32-0Ā·99)

0Ā·0449

0Ā·70 (0Ā·40-1Ā·23)

0Ā·2163

ā€ƒVancouver Island

0Ā·79(0Ā·55-1Ā·14)

0Ā·2131

1Ā·01 (0Ā·69-1Ā·47)

0Ā·9642

ā€ƒVancouver Coastal

Reference

Elixhauser index

ā€ƒNone

0Ā·82 (0Ā·61-1Ā·12)

0Ā·2167

0Ā·96 (0Ā·69-1Ā·33)

0Ā·8128

ā€ƒ1

0Ā·78(0Ā·56-1Ā·10)

0Ā·1536

0Ā·89(0Ā·63-1Ā·26)

0Ā·5260

ā€ƒ2

0Ā·67(0Ā·47-0Ā·95)

0Ā·0248

0Ā·71(0Ā·49-1Ā·01)

0Ā·0564

ā€ƒ3+

Reference

Benzodiazepine

1Ā·27 (0Ā·93-1Ā·73)

0Ā·1317

1Ā·19 (0Ā·85-1Ā·67)

0Ā·3135

Z-drugs

1Ā·35(0Ā·90-2Ā·04)

0Ā·1521

1Ā·21(0Ā·79-1Ā·86)

0Ā·3863

Sedatives

1Ā·23(0Ā·97-1Ā·58)

0Ā·0927

1Ā·04(0Ā·77-1Ā·41)

0Ā·7836

Opioids for pain

1Ā·16(0Ā·87-1Ā·55)

0Ā·3164

1Ā·15(0Ā·82-1Ā·60)

0Ā·4152

  1. Footnote: HRā€‰=ā€‰Hazard Ratio; No one in the unknown HA reflected in Table 1 had a fatal overdose, as such this group is not reflected in Table 2