MomsTalkShots, tailored educational app, improves vaccine attitudes: a randomized controlled trial

Dudley, Matthew Z.; Omer, Saad B.; O’Leary, Sean T.; Limaye, Rupali J.; Ellingson, Mallory K.; Spina, Christine I.; Brewer, Sarah E.; Bednarczyk, Robert A.; Chamberlain, Allison T.; Malik, Fauzia; Frew, Paula M.; Church-Balin, Cathy; Riley, Laura E.; Ault, Kevin A.; Orenstein, Walter A.; Halsey, Neal A.; Salmon, Daniel A.

doi:10.1186/s12889-022-14498-7

BMC Public Health

Table 2 Impact of MomsTalkShots on vaccine KAB constructs of women one month after their infant’s birth stratified by baseline vaccine intentions^a, dichotomous analysis^b

From: MomsTalkShots, tailored educational app, improves vaccine attitudes: a randomized controlled trial

	% with above average construct scores^c among those not receiving MomsTalkShots				% with above average construct scores^c among those receiving MomsTalkShots				Effect of MomsTalkShots on % with above average construct scores^c, OR (95% CI)^b
Intentions to Vaccinate^a	All	Yes	No	Unsure	All	Yes	No	Unsure	All	Yes	No	Unsure
KAB Constructs ^c
Specific safety concerns (for infant vaccines)^fh	56	49	90	89	53	47	87	81	0.89 (0.70–1.12)	0.94 (0.73–1.20)	0.62 (0.19–2.05)	0.44 (0.14–1.40)
Perceived risk (maternal influenza)^d	55	64	32	42	61	71	38	44	1.61 (1.23–2.09)	1.57 (1.12–2.20)	2.07 (1.15–3.71)	1.53 (0.70–3.34)
Confidence in vaccine efficacy (maternal influenza vaccine)^d	63	77	28	39	73	86	44	52	1.97 (1.47–2.65)	2.09 (1.36–3.22)	2.62 (1.46–4.69)	1.96 (0.90–4.26)
Perceived risk (infant whooping cough)^f	42	47	22	19	39	42	19	31	0.75 (0.57–1.00)^g	0.70 (0.51–0.96)	0.77 (0.27–2.24)	2.18 (0.68–6.96)
Confidence in vaccine efficacy (whooping cough vaccine)^e	56	68	24	47	61	72	37	41	1.01 (0.77–1.33)	0.96 (0.69–1.34)	1.42 (0.71–2.86)	0.53 (0.18–1.52
Pro-vaccine social norms^f	44	49	19	15	46	51	15	33	1.08 (0.86–1.35)	1.05 (0.83–1.34)	0.55 (0.20–1.47)	2.57 (0.97–6.85)
Perceived vaccine knowledge^f	48	53	24	28	55	59	38	33	1.39 (1.13–1.72)	1.36 (1.08–1.70)	2.04 (0.97–4.28)	1.00 (0.41–2.45)
Trust in vaccine information (from obstetricians and pediatricians)^f	53	60	23	20	59	27	26	27	1.22 (0.97–1.54)	1.22 (0.95–1.56)	1.43 (0.63–3.27)	1.12 (0.43–2.93)
Trust in vaccine information (from naturopaths and chiropractors)^f	56	57	60	51	60	61	59	51	0.83 (0.57–1.19)	0.76 (0.50–1.16)	1.04 (0.33–3.30)	0.83 (0.26–2.61)
Trust in vaccine information (from federal agencies and academic institutions)^f	48	55	18	13	49	55	14	25	1.06 (0.84–1.34)	1.02 (0.79–1.31)	0.77 (0.29–2.06)	1.88 (0.65–5.47)

^aFor constructs specific to maternal influenza disease or vaccine, “intend to vaccinate”, “intend not to vaccinate”, and “uncertain intentions” refer to maternal influenza vaccine^d; for constructs specific to maternal pertussis disease or vaccine, “intend to vaccinate”, “intend not to vaccinate”, and “uncertain intentions” refer to maternal Tdap vaccine^e; for constructs specific to infant diseases or vaccines, “intend to vaccinate”, “intend not to vaccinate”, and “uncertain intentions” refer to intending to receive all recommended infant vaccines versus intending to receive some or no recommended infant vaccines^f; for constructs relevant to both maternal and infant vaccines, “intend to vaccinate”, “intend not to vaccinate”, and “uncertain intentions” refer to intending to receive all recommended infant vaccines versus intending to receive some or no recommended infant vaccines^f
^bOR = Odds Ratio from logistic regression comparing the proportions with above average construct scores^c at follow-up between those receiving MomsTalkShots and those not receiving MomsTalkShots, controlling for the corresponding proportions with above average construct scores^c at baseline; 95%CI = 95% Confidence Interval; bolded if statistically significant (in the dichotomous analysis)
^cKAB = knowledge, attitudes, and beliefs. Summary scores were created for all KAB constructs with multiple constituent survey statements at each timepoint (see Additional file 1: Appendix 1). Dichotomous variables assessing construct summary scores coded scores above the average as 1 and scores below the average as 0
^gThis appearance of an overlap with 1 in the 95%CI is due to rounding
^hThe KAB construct “Specific safety concerns (for infant vaccines)” was created from negatively phrased survey statements, so a negative association would indicate a positive effect on vaccine perceptions. All other KAB constructs in this table were created from positively phrased survey statements, so a positive association would indicate a positive effect on vaccine perceptions

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ISSN: 1471-2458

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