Table 4 DALY of early-onset colorectal cancer in 1990 and 2019 for both sexes and all locations, with AAPC from 2009 and 2019
Location | 1990 | 2019 | AAPC % (95% CI) 1990–2019 | ||
|---|---|---|---|---|---|
Cases (95% UI) | Age-standardized DALY per 100 000 population (95% UI) | Cases (95% UI) | Age-standardized DALY per 100 000 population (95% UI) | ||
Global | 2,561,842 (2,394,962 to 2,735,823) | 77.7 (72.76 to 82.85) | 4,297,573 (3,965,485 to 4,650,790) | 76.86 (70.91 to 83.19) | -0.08 (-0.16 to 0.01) |
Sex | |||||
 Female | 1,189,993 (1,084,567 to 1,310,035) | 73.51 (67.19 to 80.77) | 1,762,817 (1,596,957 to 1,938,989) | 63.58 (57.57 to 69.95) | -0.55 (-0.68 to -0.42) |
 Male | 1,371,849 (1,260,775 to 1,508,695) | 81.74 (75.27 to 89.77) | 2,534,756 (2,278,256 to 2,814,579) | 89.95 (80.85 to 99.86) | 0.24 (0.09 to 0.39) |
SDI | |||||
 High SDI | 565,844 (551,158 to 580,209) | 92.23 (89.82 to 94.58) | 591,574 (562,033 to 624,366) | 76.85 (72.97 to 81.16) | -0.68 (-0.85 to -0.52) |
 High-middle SDI | 750,711 (696,355 to 811,081) | 97.6 (90.65 to 105.32) | 1,098,600 (994,304 to 1,214,332) | 93.91 (84.98 to 103.82) | -0.23 (-0.6 to 0.13) |
 Middle SDI | 796,532 (712,556 to 884,382) | 75.51 (67.64 to 83.73) | 1,550,467 (1,388,571 to 1,717,229) | 83.8 (75.05 to 92.8) | 0.32 (0.22 to 0.42) |
 Low-middle SDI | 333,162 (288,215 to 382,422) | 52.98 (46.04 to 60.67) | 766,284 (672,536 to 870,105) | 63.92 (56.12 to 72.57) | 0.72 (0.6 to 0.85) |
 Low SDI | 114,328 (92,257 to 139,751) | 44.09 (35.75 to 53.74) | 288,192 (245,104 to 338,714) | 47.83 (40.77 to 56.1) | 0.31 (0.26 to 0.35) |
Region | 138,575 (133,000 to 144,275) | 100.28 (96.09 to 104.6) | 100,788 (93,094 to 108,937) | 67.31 (62.02 to 72.96) | -1.46 (-1.79 to -1.13) |
 High-income Asia Pacific | |||||
  High-income North America | 178,942 (172,223 to 185,314) | 85.68 (82.47 to 88.73) | 224,187 (212,140 to 237,605) | 87.32 (82.57 to 92.65) | 0.21 (0.09 to 0.32) |
  Western Europe | 246,823 (238,646 to 255,303) | 88.27 (85.31 to 91.33) | 207,340 (193,916 to 221,500) | 63.64 (59.48 to 68.06) | -1.08 (-1.39 to -0.77) |
  Australasia | 15,611 (14,315 to 16,985) | 103.71 (95.1 to 112.84) | 16,851 (14,264 to 19,864) | 78.69 (66.43 to 92.97) | -0.81 (-0.94 to -0.68) |
  Andean Latin America | 10,727 (8924 to 12,898) | 49.86 (41.7 to 59.65) | 27,087 (20,040 to 35,742) | 61.07 (45.18 to 80.59) | 0.69 (0.42 to 0.96) |
  Tropical Latin America | 63,639 (59,960 to 67,593) | 68.09 (64.23 to 72.22) | 140,322 (130,057 to 151,074) | 81.18 (75.22 to 87.43) | 0.68 (0.54 to 0.82) |
  Central Latin America | 46,399 (44,064 to 48,878) | 49.98 (47.55 to 52.56) | 129,267 (109,626 to 152,485) | 71.99 (61.05 to 84.91) | 1.26 (1.19 to 1.33) |
  Southern Latin America | 28,721 (26,077 to 31,609) | 89.25 (81.09 to 98.15) | 50,371 (43,173 to 58,593) | 102.82 (88.05 to 119.71) | 0.54 (0.32 to 0.75) |
  Caribbean | 15,941 (14,207 to 17,883) | 74.04 (66.22 to 82.81) | 27,802 (22,083 to 34,737) | 83.05 (65.9 to 103.85) | 0.41 (0.1 to 0.71) |
  Central Europe | 102,738 (97,982 to 107,802) | 117.71 (112.23 to 123.55) | 88,960 (75,933 to 103,094) | 97 (82.83 to 112.41) | -0.79 (-1.1 to -0.47) |
  Eastern Europe | 173,230 (159,657 to 185,203) | 114.92 (105.98 to 122.84) | 168,658 (147,831 to 192,396) | 102.48 (89.82 to 116.92) | -0.37 (-1.97 to 1.27) |
  Central Asia | 42,467 (39,423 to 45,696) | 111.7 (103.94 to 119.88) | 49,744 (43,004 to 57,382) | 74.4 (64.32 to 85.82) | -1.65 (-2.03 to -1.28) |
  North Africa and Middle East | 113,331 (91,128 to 142,353) | 62.75 (50.66 to 78.62) | 273,698 (231,829 to 322,390) | 60.49 (51.23 to 71.25) | -0.07 (-0.23 to 0.1) |
  South Asia | 248,721 (211,957 to 290,817) | 39.47 (33.83 to 45.97) | 616,964 (520,893 to 727,009) | 49.49 (41.81 to 58.31) | 0.86 (0.66 to 1.07) |
  Southeast Asia | 219,226 (183,062 to 252,017) | 80.7 (67.78 to 92.54) | 522,972 (427,068 to 624,755) | 101.43 (82.86 to 121.14) | 0.81 (0.7 to 0.92) |
  East Asia | 805,205 (689,571 to 932,724) | 97.01 (83.09 to 112.38) | 1,366,228 (1,152,737 to 1,609,615) | 111.28 (94.03 to 130.8) | 0.61 (0.26 to 0.97) |
  Oceania | 2224 (1670 to 2942) | 61.24 (46.13 to 80.7) | 5723 (4069 to 7991) | 66.91 (47.56 to 93.39) | 0.3 (0.13 to 0.48) |
  Western Sub-Saharan Africa | 33,034 (25,850 to 41,448) | 34.89 (27.32 to 43.71) | 97,086 (76,476 to 121,008) | 40.6 (32.07 to 50.55) | 0.55 (0.4 to 0.7) |
  Eastern Sub-Saharan Africa | 43,415 (33,586 to 54,521) | 50.41 (39.23 to 63.13) | 115,961 (93,351 to 143,938) | 54.66 (44.11 to 67.77) | 0.25 (0.18 to 0.31) |
  Central Sub-Saharan Africa | 11,965 (8394 to 16,739) | 46.31 (32.77 to 64.43) | 30,537 (20,886 to 43,251) | 44.71 (30.65 to 63.11) | -0.13 (-0.24 to -0.02) |
  Southern Sub-Saharan Africa | 20,906 (17,964 to 24,174) | 73.03 (63.04 to 83.99) | 37,028 (28,480 to 46,855) | 67.63 (52.21 to 85.35) | -0.56 (-0.98 to -0.15) |