Table 2 Comparison of characteristics between QRISK® risk calculator and WHO/ISH risk charts

Derivation study

Prospective cohort database (version 19 of the QRESEARCH database)

Hypothetical cohorts for different 14 sub-regions derived from the WHO Comparative Risk Assessment study [37]

Statistical method

Cox proportional hazards models

Non- specified Modelling approach

Population of study

2.29 million patients

Not applicable

Sample size

1,535, 583 patients

(Simple random sampling)

Not applicable

Duration of the study

1 January 1993 to 31 March 2008

2007

Age of participants

35—75

40—79

Country of validation

United Kingdom

Not applicable

Ethnicity involved

White/not-recorded, Indian, Pakistani, Bangladeshi, other-Asian, black-African, black-Caribbean, Chinese, Mixed

Not involved

Number of variables

14

6

Type of variable

• Fixed Risk Factors

• Modifiable Risk Factors

• Ongoing Clinical Conditions

• Fixed Risk Factors (Age, sex)

• Modifiable Risk Factors

 + Diabetes

Applicability and ease of use

• Online available calculator

• Clinical and lab variables are needed for more accurate personalized risk

Two paper-based versions of WHO/ISH risk charts for each sub-region

Discrimination in AUROC

0.792

0.613

(Discrimination in Asian population)

10-year risk estimate

Percentage & Categories

Categories

Risk categories

• < 5%,

• 5- 10%,

• 10–20%,

• > 20%

• Green < 10%

• Yellow 10% to < 20%

• Orange 20% to < 30%

• Red 30% to < 40%

• Deep Red > 40%

Costs involved

• Involve more costs for lab and clinical examination required for complete risk assessment

• Fewer costs are involved, especially for charts without blood cholesterol investigation