Characteristics | QRISK® | WHO/ISH risk charts |
---|---|---|
Derivation study | Prospective cohort database (version 19 of the QRESEARCH database) | Hypothetical cohorts for different 14 sub-regions derived from the WHO Comparative Risk Assessment study [37] |
Statistical method | Cox proportional hazards models | Non- specified Modelling approach |
Population of study | 2.29 million patients | Not applicable |
Sample size | 1,535, 583 patients (Simple random sampling) | Not applicable |
Duration of the study | 1 January 1993 to 31 March 2008 | 2007 |
Age of participants | 35—75 | 40—79 |
Country of validation | United Kingdom | Not applicable |
Ethnicity involved | White/not-recorded, Indian, Pakistani, Bangladeshi, other-Asian, black-African, black-Caribbean, Chinese, Mixed | Not involved |
Number of variables | 14 | 6 |
Type of variable | • Fixed Risk Factors • Modifiable Risk Factors • Ongoing Clinical Conditions | • Fixed Risk Factors (Age, sex) • Modifiable Risk Factors  + Diabetes |
Applicability and ease of use | • Online available calculator • Clinical and lab variables are needed for more accurate personalized risk | Two paper-based versions of WHO/ISH risk charts for each sub-region |
Discrimination in AUROC | 0.792 | 0.613 (Discrimination in Asian population) |
10-year risk estimate | Percentage & Categories | Categories |
Risk categories | • < 5%, • 5- 10%, • 10–20%, • > 20% | • Green < 10% • Yellow 10% to < 20% • Orange 20% to < 30% • Red 30% to < 40% • Deep Red > 40% |
Costs involved | • Involve more costs for lab and clinical examination required for complete risk assessment | • Fewer costs are involved, especially for charts without blood cholesterol investigation |