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Table 2 Changes in demographic characteristics before and after vaccination

From: Spatial–temporal-demographic and virological changes of hand, foot and mouth disease incidence after vaccination in a vulnerable region of China

Variables

2012–2016

2017–2020

p value

Total

82 944(215.22)

60 436(179.81)

 < 0.001

Sex [n (/105)]

 Male

50 891(262.24)

36 065(209.94)

 < 0.001

 Female

32 053(167.53)

24 371(148.31)

 < 0.001

Age group (years old) [n (/105)]

 0–4

74 200(3 088.63)

53 744(2 635.19)

 < 0.001

 5–9

7 709(308.20)

5 557(262.24)

 < 0.001

 10–14

715(32.69)

716(36.85)

0.312

  ≥ 15

320(1.02)

419(1.52)

0.013

Childcare patterns [n (%)]

 Scattered children

56 245(67.81)

42 702(70.66)

 < 0.001

 Kindergarten children

23 708(28.58)

14 784(24.46)

 Student

2 762(3.33)

2 637(4.36)

 Other patterns

229(0.28)

313(0.52)

Residence [n (/105)]

 Yaohai

13 652(286.60)

9 803(226.74)

 < 0.001

 Luyang

6 796(211.47)

4 396(160.29)

 < 0.001

 Shushan

18 280(300.78)

13 556(236.76)

 < 0.001

 Baohe

13 251(294.77)

10 320(250.35)

 < 0.001

 Chaohu

7 443(190.80)

4 185(134.19)

 < 0.001

 Changfeng

4 418(139.33)

4 118(147.85)

0.203

 Feidong

6 277(145.50)

4 781(133.79)

0.039

 Feixi

7 714(206.49)

5 879(177.69)

 < 0.001

 Lujiang

5 113(105.06)

3 398(86.88)

 < 0.001

Pathogen [n (%)]

 CV-A16

506(29.68)

426(24.18)

0.100

 EV-A71

603(35.37)

80(4.54)

 < 0.001

 Other Enterovirusesa

596(34.96)

885(50.23)

 < 0.001

 CV-A6

-

357(20.26)

-

 CV-A10

-

14(0.79)

-

Severe cases [n (%)]

108(0.13)

6(0.01)

 < 0.001

  1. aOther Enteroviruses included CV-A6 and CV-A10 prior to 2018, both were not included after 2018