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Table 2 Trends in Age-Adjusted Thyroid Cancer Incidence Rates by States, 2000–2017

From: Thyroid cancer incidence trend and association with obesity, physical activity in the United States

  2000–2017 Incidence Rate cases/100000 PY Trend 1/Trend 3 Trend 2/Trend 4 2000–2017
States No of new cases Age adjusted/ 100 000 (95% CI) 2000 2009 2015 2017 Years APC (95%CI) P Value Years APC (95%CI) P Value AAPC (95%CI) P Value
1. Rising trends
 Arkansas 4578 9.0 (8.7, 9.2)   16.8 21.6 19.6 2001–2008 10.6a (6.6, 14.7)  < 0.001 2008–2017 2.4a (0.6, 4.3) 0.015 5.9a (4.1, 7.7)  < 0.05
 Delaware 2189 13.2 (12.6,13.8) 11.2 19.4 21.4 19.6 2000–2017 2.6a (1.1, 4.2) 0.002     2.6a (1.1, 4.2)  < 0.05
 Georgia 17,137 10.1 (9.9,10.2) 12.2 19.2 22.0 20.8 2000–2008 7.3a (4.5, 10.2)  < 0.001 2008–2017 2.1a (0.6, 3.7) 0.011 4.5a (3.1, 5.9)  < 0.05
 Iowa 6729 12.1 (11.8,12.4) 12.0 23.4 24.1 19.9 2000–2017 3.7a (2.3, 5.1)  < 0.001     3.7a (2.3, 5.1)  < 0.05
 New Mexico 4977 13.6 (13.2,14.0) 10.1 24.5 27.5 24.7 2000–2017 2.2a (1.0, 3.5) 0.002     2.2a (1.0, 3.5)  < 0.05
 North Dakota 1598 12.9 (12.3,13.5)   23.4 26.8 26.6 2000–2017 4.9a (2.4, 7.6) 0.001     4.9a (2.4, 7.6)  < 0.05
 Oklahoma 6479 9.6 (9.3, 9.8) 7.1 17.9 23.8 20.8 2000–2006 16.9a (7.4, 27.3) 0.002 2006–2017 3.5a (1.3, 5.8) 0.004 8.1a (4.9, 11.4)  < 0.05
 South Dakota 1589 11.5 (10.9,12.0)   22.7 22.3 19.0 2001–2017 3.9a (1.7, 6.1) 0.002     3.9a (1.7, 6.1)  < 0.05
 Vermont 1443 12.1 (11.5,12.8)   22.9 20.8 18.9 2002–2017 2.2a (0.1, 4.3) 0.044     2.2a (0.1, 4.3)  < 0.05
 Wisconsin 11,610 11.1 (10.9,11.3) 10.0 19.7 21.7 21.2 2000–2009 7.8a (5.5, 10.1)  < 0.001 2009–2017 2.1a (0.3, 3.9) 0.028 5.0a (3.7, 6.4)  < 0.05
2. No significant change
 Alabama 7232 8.2 (8.0, 8.4) 8.9 14.3 17.6 17.0 2000–2008 8.1a (4.9, 11.4)  < 0.001 2008–2017 0.4 (-1.5, 2.4) 0.628 4.0a (2.4, 5.6)  < 0.05
 Alaska 1364 11.1 (10.5,11.7)   17.0 17.7 18.9 2005–2017 0.7 (-2.1, 3.6) 0.589     0.7 (-2.1, 3.6)  > 0.05
 Arizona 14,736 13.1 (12.9,13.3) 10.3 24.9 22.6 18.1 2000–2005 16.5a (11.1, 22.1)  < 0.001 2005–2010 4.3 (-0.2, 9.0) 0.059 3.7a (1.4, 6.0)  < 0.05
        2010–2015 -2.6 (-6.4, 1.3) 0.153 2015–2017 -10.6 (-21.2, 1.4) 0.073   
 California 71,925 10.8 (10.8,10.9) 11.4 20.3 23.3 21.3 2000–2008 7.6a (6.4, 8.9)  < 0.001 2008–2015 2.4a (1.1, 3.7) 0.002 3.9a (2.8, 4.9)  < 0.05
        2015–2017 -5.3 (-12.2, 2.1) 0.139      
 Connecticut 10,859 16.1 (15.8,16.4) 13.6 30.6 27.5 23.0 2000–2007 12.1a (9.2, 15.2)  < 0.001 2007–2014 0.6 (-1.9, 3.2) 0.601 3.7a (1.9, 5.6)  < 0.05
        2014–2017 -7.3 (-14, 0) 0.050      
 District of Columbia 1442 12.5 (11.9,13.2) 14.2 30.6 17.6 25.1 2000–2017 2.1 (-0.1, 4.3) 0.061     2.1 (-0.1, 4.3)  > 0.05
 Florida 38,757 10.6 (10.5,10.7) 12.4 19.9 19.9 18.2 2000–2008 7.4a (5.3, 9.6)  < 0.001 2008–2017 -0.3 (-1.7, 1.0) 0.602 3.2a (2.1, 4.4)  < 0.05
 Hawaii 3335 13.3 (12.8,13.7) 11.5 22.5 21 18.4 2000–2010 6.0a (2.7, 9.3) 0.001 2010–2017 -3.1 (-7.2, 1.2) 0.140 2.1 (-0.2, 4.5)  > 0.05
 Idaho 3772 14.1 (13.7,14.6) 8.8 25.0 25.1 19.2 2000–2008 13.4a (7.8, 19.2)  < 0.001 2008–2017 -2.2 (-4.9, 0.7) 0.122 4.9a (2.2, 7.6)  < 0.05
 Indiana 12,196 10.4 (10.2,10.6) 11.2 18.8 19.5 17.0 2000–2010 6.3a (4.9, 7.7)  < 0.001 2010–2017 -1.0 (-2.8, 0.9) 0.267 3.2a (2.2, 4.3)  < 0.05
 Kansas 7027 13.8 (13.5,14.1) 13.5 24.2 29.2 21.4 2000–2010 9.0a (6.0, 12.1)  < 0.001 2010–2017 -3.3 (-6.7, 0.2) 0.127 3.7a (1.7, 5.8)  < 0.05
 Kentucky 10,053 12.5 (12.2,12.7) 9.5 24.3 26.5 24.7 2000–2009 10.8a (8.4, 13.2)  < 0.001 2009–2017 1.0 (-0.8, 2.8) 0.246 6.1a (4.7–7.4)  < 0.05
 Louisiana 8926 10.7 (10.5,11.0) 9.7 19.8 26.1 24.3 2000–2013 7.7a (5.9, 9.5)  < 0.001 2013–2017 -2.3 (-9.0, 4.9) 0.495 5.2a (3.3, 7.3)  < 0.05
 Maine 3238 12.5 (12.1,12.9) 6.9 18.1 28.8 18.8 2000–2015 8.1a (5.8, 10.5)  < 0.001 2015–2017 -19.8 (-45.4,17.8) 0.237 4.4 (-0.2, 9.2)  > 0.05
 Massachusetts 21,047 16.8 (16.6,17.1) 13.3 33.2 32.7 26.7 2000–2007 16.1a (12.1, 20.2)  < 0.001 2007–2017 -1.0 (-2.4, 0.4) 0.157 5.7a (4.2, 7.3)  < 0.05
 Minnesota 10,618 11.0 (10.8,11.2) 9.6 17.3 20.9 17.5 2000–2013 5.9a (4.4, 7.4)  < 0.001 2013–2017 -4.2 (-10.3, 2.3) 0.181 3.4a (1.7, 5.2)  < 0.05
 Mississippi 4287 9.5 (9.2, 9.8)   17.7 20.1 14.8 2003–2011 7.2a (3.1, 11.4) 0.002 2011–2017 -4.1 (-8.9, 1.0) 0.102 2.2 (-0.6, 5.0)  > 0.05
 Missouri 11,997 10.9 (10.7,11.1) 11.3 22.5 19.2 19.3 2000–2008 9.7a (7.3, 12.1)  < 0.001 2008–2017 -1.2 (-2.6, 0.1) 0.071 3.8a (2.6, 5.0)  < 0.05
 Montana 2370 13.0 (12.4,13.5) 10.7 24.7 24.2 14.9 2000–2015 4.4a (2.6, 6.2)  < 0.001 2015–2017 -24.0 (-46.3, 7.6) 0.112 0.6 (-3.3, 4.7)  > 0.05
 Nebraska 4079 12.5 (12.1,12.9) 9.9 24.7 24.2 23.7 2000–2008 9.4a (5.1, 13.8)  < 0.001 2008–2017 0.3 (-2.1, 2.7) 0.807 4.5a (2.4, 6.6)  < 0.05
 New Hampshire 3252 12.8 (12.4,13.3) 10.5 22.1 20.7 20.6 2000–2006 18.1a (6.9, 30.5) 0.003 2006–2017 -0.3 (-2.9, 2.4) 0.815 5.9a (2.2, 9.7)  < 0.05
 New Jersey 26,846 16.1 (16.0,16.3) 16.7 32.0 29.2 28.2 2000–2010 7.0a (5.7, 8.2)  < 0.001 2010–2017 -1.4 (-2.9, 0.2) 0.086 3.5a (2.6, 4.4)  < 0.05
 Ohio 25,253 11.7 (11.5,11.8) 9.9 21.4 22.3 23.6 2000–2009 9.6a (7.3, 12.1)  < 0.001 2009–2017 1.1 (-0.7, 2.9) 0. 217 5.5a (4.2, 6.9)  < 0.05
 Oregon 7933 11.2 (10.9,11.4) 9.5 17.9 20.8 18.5 2000–2008 11.1a (6.3, 16.3)  < 0.001 2008–2017 0.7 (-1.9, 3.4) 0.583 5.5a (3.1, 7.9)  < 0.05
 Tennessee 13,141 11.2 (11.0,11.4) 10.1 19.8 20.5 19.1 2000–2008 11.3a (7.6, 15.1)  < 0.001 2008–2017 -1.1 (-3.1, 0.9 0.240 4.5a (2.7, 6.4)  < 0.05
 Virginia 15,605 10.6 (10.4,10.7) 10.4 20.0 21.2 18.9 2000–2009 10.4a (7.6, 13.2)  < 0.001 2009–2017 -0.2 (-2.2, 1.8) 0.842 5.3a (3.7, 6.9)  < 0.05
 Washington 14,659 11.9 (11.7,12.1) 10.4 21.6 21.5 18.8 2000–2011 6.6a (4.6, 8.7)  < 0.001 2011–2017 -2.9 (-6.3, 0.6) 0.093 3.1a (1.5, 4.8)  < 0.05
 West Virginia 4593 12.7 (12.3,13.1) 10.3 18.6 23.0 25.7 2000–2012 7.2a (5.4, 9.1)  < 0.001 2012–2017 -1.6 (-6.3, 3.4) 0.495 4.6a (2.8, 6.4)  < 0.05
 Wyoming 1272 12.7 (12.0,13.5)   14.7 17.8 24.5 2003–2017 -0.7 (-3.1, 1.7) 0.536     -0.7 (-3.1, 1.7)  > 0.05
3. Decreasing trends
 Colorado 11,810 13.0 (12.8,13.2) 10.2 25.4 24.1 21.1 2000–2010 9.1a (7.8, 10.4)  < 0.001 2010–2017 -3.6a (-4.9, -2.2)  < 0.001 3.7a (2.8, 4.6)  < 0.05
 Illinois 28,879 12.3 (12.2,12.5) 12.3 22.0 26.5 22.5 2000–2007 8.9a (7.1, 10.8)  < 0.001 2007–2015 2.8* (1.5, 4.1) 0.001 3.9a (2.6, 5.1)  < 0.05
        2015–2017 -8.5a (-16.2, -0.1) 0.049      
 Maryland 12,866 12.8 (12.6,13.1) 15.7 27.2 23.6 19.7 2000–2013 4.7a (3.3, 6.0)  < 0.001 2013–2017 -8.5a (-14.4, -2.3) 0.012 1.4 (-0.3, 3.1)  > 0.05
 Michigan 20,624 11.1 (10.9,11.2) 11.5 20.8 19.4 17.4 2000–2010 7.0a (5.3, 8.7) 0.001 2010–2017 -2.5a (-4.7, -0.4) 0.025 3.0a (1.8, 4.2)  < 0.05
 Nevada 6536 13.6 (13.3,13.9) 12.1 28.7 27.5 21.6 2000–2013 6.0a (3.9, 8.1)  < 0.001 2013–2017 -8.8a (-16.4,-0.6) 0.038 2.3 (0, 4.7)  > 0.05
 New York 57,216 15.7 (15.5,15.8) 14.0 30.0 30.2 27.2 2000–2003 4.4 (-0.4, 9.3) 0.068 2003–2008 12.1a (9.6, 14.8)  < 0.001 3.9a (2.8, 5.1)  < 0.05
        2008–2013 2.6a (0.7, 4.6) 0.015 2013–2017 -4.2a (-5.9, -2.4) 0.001   
 North Carolina 18,409 10.6 (10.5,10.8) 9.4 21.6 20.0 17.4 2000–2003 2.0 (-14.7, 22.1) 0.798 2003–2006 26.8 (-5.3, 69.8) 0.096 3.8 (-1.6, 9.5)  > 0.05
        2006–2013 2.4 (-1.3, 6.3) 0.172 2013–2017 -7.4a (-13.2,-1.2) 0.027   
 Pennsylvania 41,361 17.1 (17.0,17.3) 14.9 33.2 29.2 26.5 2000–2010 8.2a (7.1, 9.2)  < 0.001 2010–2017 -3.4a (-4.7, -2.2)  < 0.001 3.2a (2.5, 3.9)  < 0.05
 Rhode Island 3220 16.1 (15.5,16.7) 12.2 32.5 26.5 24.3 2000–2010 10.8a (7.5, 14.2)  < 0.001 2010–2017 -4.8a (-8.6, -0.9) 0.020 4.1a (1.8, 6.4)  < 0.05
 South Carolina 8117 9.5 (9.3, 9.7) 10.1 17.8 21.0 17.0 2000–2012 7.7a (6.6, 8.7)  < 0.001 2012–2017 -4.0a (-6.6, -1.3) 0.007 4.1a (3.1, 5.1)  < 0.05
 Texas 46,306 10.8 (10.7,10.9) 11.7 23.3 20.9 19.2 2000–2006 10.1a (7.3, 12.9)  < 0.001 2006–2011 3.2 (-0.3, 6.9) 0.070 3.2a (1.9, 4.5)  < 0.05
        2011–2017 -3.3a (-4.8, -1.8) 0.001      
  1. aThe difference was statistically significant