Table 2 Trends in Age-Adjusted Thyroid Cancer Incidence Rates by States, 2000–2017
From: Thyroid cancer incidence trend and association with obesity, physical activity in the United States
|  | 2000–2017 | Incidence Rate cases/100000 PY | Trend 1/Trend 3 | Trend 2/Trend 4 | 2000–2017 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
States | No of new cases | Age adjusted/ 100 000 (95% CI) | 2000 | 2009 | 2015 | 2017 | Years | APC (95%CI) | P Value | Years | APC (95%CI) | P Value | AAPC (95%CI) | P Value |
1. Rising trends | ||||||||||||||
 Arkansas | 4578 | 9.0 (8.7, 9.2) |  | 16.8 | 21.6 | 19.6 | 2001–2008 | 10.6a (6.6, 14.7) |  < 0.001 | 2008–2017 | 2.4a (0.6, 4.3) | 0.015 | 5.9a (4.1, 7.7) |  < 0.05 |
 Delaware | 2189 | 13.2 (12.6,13.8) | 11.2 | 19.4 | 21.4 | 19.6 | 2000–2017 | 2.6a (1.1, 4.2) | 0.002 |  |  |  | 2.6a (1.1, 4.2) |  < 0.05 |
 Georgia | 17,137 | 10.1 (9.9,10.2) | 12.2 | 19.2 | 22.0 | 20.8 | 2000–2008 | 7.3a (4.5, 10.2) |  < 0.001 | 2008–2017 | 2.1a (0.6, 3.7) | 0.011 | 4.5a (3.1, 5.9) |  < 0.05 |
 Iowa | 6729 | 12.1 (11.8,12.4) | 12.0 | 23.4 | 24.1 | 19.9 | 2000–2017 | 3.7a (2.3, 5.1) |  < 0.001 |  |  |  | 3.7a (2.3, 5.1) |  < 0.05 |
 New Mexico | 4977 | 13.6 (13.2,14.0) | 10.1 | 24.5 | 27.5 | 24.7 | 2000–2017 | 2.2a (1.0, 3.5) | 0.002 |  |  |  | 2.2a (1.0, 3.5) |  < 0.05 |
 North Dakota | 1598 | 12.9 (12.3,13.5) |  | 23.4 | 26.8 | 26.6 | 2000–2017 | 4.9a (2.4, 7.6) | 0.001 |  |  |  | 4.9a (2.4, 7.6) |  < 0.05 |
 Oklahoma | 6479 | 9.6 (9.3, 9.8) | 7.1 | 17.9 | 23.8 | 20.8 | 2000–2006 | 16.9a (7.4, 27.3) | 0.002 | 2006–2017 | 3.5a (1.3, 5.8) | 0.004 | 8.1a (4.9, 11.4) |  < 0.05 |
 South Dakota | 1589 | 11.5 (10.9,12.0) |  | 22.7 | 22.3 | 19.0 | 2001–2017 | 3.9a (1.7, 6.1) | 0.002 |  |  |  | 3.9a (1.7, 6.1) |  < 0.05 |
 Vermont | 1443 | 12.1 (11.5,12.8) |  | 22.9 | 20.8 | 18.9 | 2002–2017 | 2.2a (0.1, 4.3) | 0.044 |  |  |  | 2.2a (0.1, 4.3) |  < 0.05 |
 Wisconsin | 11,610 | 11.1 (10.9,11.3) | 10.0 | 19.7 | 21.7 | 21.2 | 2000–2009 | 7.8a (5.5, 10.1) |  < 0.001 | 2009–2017 | 2.1a (0.3, 3.9) | 0.028 | 5.0a (3.7, 6.4) |  < 0.05 |
2. No significant change | ||||||||||||||
 Alabama | 7232 | 8.2 (8.0, 8.4) | 8.9 | 14.3 | 17.6 | 17.0 | 2000–2008 | 8.1a (4.9, 11.4) |  < 0.001 | 2008–2017 | 0.4 (-1.5, 2.4) | 0.628 | 4.0a (2.4, 5.6) |  < 0.05 |
 Alaska | 1364 | 11.1 (10.5,11.7) |  | 17.0 | 17.7 | 18.9 | 2005–2017 | 0.7 (-2.1, 3.6) | 0.589 |  |  |  | 0.7 (-2.1, 3.6) |  > 0.05 |
 Arizona | 14,736 | 13.1 (12.9,13.3) | 10.3 | 24.9 | 22.6 | 18.1 | 2000–2005 | 16.5a (11.1, 22.1) |  < 0.001 | 2005–2010 | 4.3 (-0.2, 9.0) | 0.059 | 3.7a (1.4, 6.0) |  < 0.05 |
|  |  |  |  |  |  |  | 2010–2015 | -2.6 (-6.4, 1.3) | 0.153 | 2015–2017 | -10.6 (-21.2, 1.4) | 0.073 |  |  |
 California | 71,925 | 10.8 (10.8,10.9) | 11.4 | 20.3 | 23.3 | 21.3 | 2000–2008 | 7.6a (6.4, 8.9) |  < 0.001 | 2008–2015 | 2.4a (1.1, 3.7) | 0.002 | 3.9a (2.8, 4.9) |  < 0.05 |
|  |  |  |  |  |  |  | 2015–2017 | -5.3 (-12.2, 2.1) | 0.139 |  |  |  |  |  |
 Connecticut | 10,859 | 16.1 (15.8,16.4) | 13.6 | 30.6 | 27.5 | 23.0 | 2000–2007 | 12.1a (9.2, 15.2) |  < 0.001 | 2007–2014 | 0.6 (-1.9, 3.2) | 0.601 | 3.7a (1.9, 5.6) |  < 0.05 |
|  |  |  |  |  |  |  | 2014–2017 | -7.3 (-14, 0) | 0.050 |  |  |  |  |  |
 District of Columbia | 1442 | 12.5 (11.9,13.2) | 14.2 | 30.6 | 17.6 | 25.1 | 2000–2017 | 2.1 (-0.1, 4.3) | 0.061 |  |  |  | 2.1 (-0.1, 4.3) |  > 0.05 |
 Florida | 38,757 | 10.6 (10.5,10.7) | 12.4 | 19.9 | 19.9 | 18.2 | 2000–2008 | 7.4a (5.3, 9.6) |  < 0.001 | 2008–2017 | -0.3 (-1.7, 1.0) | 0.602 | 3.2a (2.1, 4.4) |  < 0.05 |
 Hawaii | 3335 | 13.3 (12.8,13.7) | 11.5 | 22.5 | 21 | 18.4 | 2000–2010 | 6.0a (2.7, 9.3) | 0.001 | 2010–2017 | -3.1 (-7.2, 1.2) | 0.140 | 2.1 (-0.2, 4.5) |  > 0.05 |
 Idaho | 3772 | 14.1 (13.7,14.6) | 8.8 | 25.0 | 25.1 | 19.2 | 2000–2008 | 13.4a (7.8, 19.2) |  < 0.001 | 2008–2017 | -2.2 (-4.9, 0.7) | 0.122 | 4.9a (2.2, 7.6) |  < 0.05 |
 Indiana | 12,196 | 10.4 (10.2,10.6) | 11.2 | 18.8 | 19.5 | 17.0 | 2000–2010 | 6.3a (4.9, 7.7) |  < 0.001 | 2010–2017 | -1.0 (-2.8, 0.9) | 0.267 | 3.2a (2.2, 4.3) |  < 0.05 |
 Kansas | 7027 | 13.8 (13.5,14.1) | 13.5 | 24.2 | 29.2 | 21.4 | 2000–2010 | 9.0a (6.0, 12.1) |  < 0.001 | 2010–2017 | -3.3 (-6.7, 0.2) | 0.127 | 3.7a (1.7, 5.8) |  < 0.05 |
 Kentucky | 10,053 | 12.5 (12.2,12.7) | 9.5 | 24.3 | 26.5 | 24.7 | 2000–2009 | 10.8a (8.4, 13.2) |  < 0.001 | 2009–2017 | 1.0 (-0.8, 2.8) | 0.246 | 6.1a (4.7–7.4) |  < 0.05 |
 Louisiana | 8926 | 10.7 (10.5,11.0) | 9.7 | 19.8 | 26.1 | 24.3 | 2000–2013 | 7.7a (5.9, 9.5) |  < 0.001 | 2013–2017 | -2.3 (-9.0, 4.9) | 0.495 | 5.2a (3.3, 7.3) |  < 0.05 |
 Maine | 3238 | 12.5 (12.1,12.9) | 6.9 | 18.1 | 28.8 | 18.8 | 2000–2015 | 8.1a (5.8, 10.5) |  < 0.001 | 2015–2017 | -19.8 (-45.4,17.8) | 0.237 | 4.4 (-0.2, 9.2) |  > 0.05 |
 Massachusetts | 21,047 | 16.8 (16.6,17.1) | 13.3 | 33.2 | 32.7 | 26.7 | 2000–2007 | 16.1a (12.1, 20.2) |  < 0.001 | 2007–2017 | -1.0 (-2.4, 0.4) | 0.157 | 5.7a (4.2, 7.3) |  < 0.05 |
 Minnesota | 10,618 | 11.0 (10.8,11.2) | 9.6 | 17.3 | 20.9 | 17.5 | 2000–2013 | 5.9a (4.4, 7.4) |  < 0.001 | 2013–2017 | -4.2 (-10.3, 2.3) | 0.181 | 3.4a (1.7, 5.2) |  < 0.05 |
 Mississippi | 4287 | 9.5 (9.2, 9.8) |  | 17.7 | 20.1 | 14.8 | 2003–2011 | 7.2a (3.1, 11.4) | 0.002 | 2011–2017 | -4.1 (-8.9, 1.0) | 0.102 | 2.2 (-0.6, 5.0) |  > 0.05 |
 Missouri | 11,997 | 10.9 (10.7,11.1) | 11.3 | 22.5 | 19.2 | 19.3 | 2000–2008 | 9.7a (7.3, 12.1) |  < 0.001 | 2008–2017 | -1.2 (-2.6, 0.1) | 0.071 | 3.8a (2.6, 5.0) |  < 0.05 |
 Montana | 2370 | 13.0 (12.4,13.5) | 10.7 | 24.7 | 24.2 | 14.9 | 2000–2015 | 4.4a (2.6, 6.2) |  < 0.001 | 2015–2017 | -24.0 (-46.3, 7.6) | 0.112 | 0.6 (-3.3, 4.7) |  > 0.05 |
 Nebraska | 4079 | 12.5 (12.1,12.9) | 9.9 | 24.7 | 24.2 | 23.7 | 2000–2008 | 9.4a (5.1, 13.8) |  < 0.001 | 2008–2017 | 0.3 (-2.1, 2.7) | 0.807 | 4.5a (2.4, 6.6) |  < 0.05 |
 New Hampshire | 3252 | 12.8 (12.4,13.3) | 10.5 | 22.1 | 20.7 | 20.6 | 2000–2006 | 18.1a (6.9, 30.5) | 0.003 | 2006–2017 | -0.3 (-2.9, 2.4) | 0.815 | 5.9a (2.2, 9.7) |  < 0.05 |
 New Jersey | 26,846 | 16.1 (16.0,16.3) | 16.7 | 32.0 | 29.2 | 28.2 | 2000–2010 | 7.0a (5.7, 8.2) |  < 0.001 | 2010–2017 | -1.4 (-2.9, 0.2) | 0.086 | 3.5a (2.6, 4.4) |  < 0.05 |
 Ohio | 25,253 | 11.7 (11.5,11.8) | 9.9 | 21.4 | 22.3 | 23.6 | 2000–2009 | 9.6a (7.3, 12.1) |  < 0.001 | 2009–2017 | 1.1 (-0.7, 2.9) | 0. 217 | 5.5a (4.2, 6.9) |  < 0.05 |
 Oregon | 7933 | 11.2 (10.9,11.4) | 9.5 | 17.9 | 20.8 | 18.5 | 2000–2008 | 11.1a (6.3, 16.3) |  < 0.001 | 2008–2017 | 0.7 (-1.9, 3.4) | 0.583 | 5.5a (3.1, 7.9) |  < 0.05 |
 Tennessee | 13,141 | 11.2 (11.0,11.4) | 10.1 | 19.8 | 20.5 | 19.1 | 2000–2008 | 11.3a (7.6, 15.1) |  < 0.001 | 2008–2017 | -1.1 (-3.1, 0.9 | 0.240 | 4.5a (2.7, 6.4) |  < 0.05 |
 Virginia | 15,605 | 10.6 (10.4,10.7) | 10.4 | 20.0 | 21.2 | 18.9 | 2000–2009 | 10.4a (7.6, 13.2) |  < 0.001 | 2009–2017 | -0.2 (-2.2, 1.8) | 0.842 | 5.3a (3.7, 6.9) |  < 0.05 |
 Washington | 14,659 | 11.9 (11.7,12.1) | 10.4 | 21.6 | 21.5 | 18.8 | 2000–2011 | 6.6a (4.6, 8.7) |  < 0.001 | 2011–2017 | -2.9 (-6.3, 0.6) | 0.093 | 3.1a (1.5, 4.8) |  < 0.05 |
 West Virginia | 4593 | 12.7 (12.3,13.1) | 10.3 | 18.6 | 23.0 | 25.7 | 2000–2012 | 7.2a (5.4, 9.1) |  < 0.001 | 2012–2017 | -1.6 (-6.3, 3.4) | 0.495 | 4.6a (2.8, 6.4) |  < 0.05 |
 Wyoming | 1272 | 12.7 (12.0,13.5) |  | 14.7 | 17.8 | 24.5 | 2003–2017 | -0.7 (-3.1, 1.7) | 0.536 |  |  |  | -0.7 (-3.1, 1.7) |  > 0.05 |
3. Decreasing trends | ||||||||||||||
 Colorado | 11,810 | 13.0 (12.8,13.2) | 10.2 | 25.4 | 24.1 | 21.1 | 2000–2010 | 9.1a (7.8, 10.4) |  < 0.001 | 2010–2017 | -3.6a (-4.9, -2.2) |  < 0.001 | 3.7a (2.8, 4.6) |  < 0.05 |
 Illinois | 28,879 | 12.3 (12.2,12.5) | 12.3 | 22.0 | 26.5 | 22.5 | 2000–2007 | 8.9a (7.1, 10.8) |  < 0.001 | 2007–2015 | 2.8* (1.5, 4.1) | 0.001 | 3.9a (2.6, 5.1) |  < 0.05 |
|  |  |  |  |  |  |  | 2015–2017 | -8.5a (-16.2, -0.1) | 0.049 |  |  |  |  |  |
 Maryland | 12,866 | 12.8 (12.6,13.1) | 15.7 | 27.2 | 23.6 | 19.7 | 2000–2013 | 4.7a (3.3, 6.0) |  < 0.001 | 2013–2017 | -8.5a (-14.4, -2.3) | 0.012 | 1.4 (-0.3, 3.1) |  > 0.05 |
 Michigan | 20,624 | 11.1 (10.9,11.2) | 11.5 | 20.8 | 19.4 | 17.4 | 2000–2010 | 7.0a (5.3, 8.7) | 0.001 | 2010–2017 | -2.5a (-4.7, -0.4) | 0.025 | 3.0a (1.8, 4.2) |  < 0.05 |
 Nevada | 6536 | 13.6 (13.3,13.9) | 12.1 | 28.7 | 27.5 | 21.6 | 2000–2013 | 6.0a (3.9, 8.1) |  < 0.001 | 2013–2017 | -8.8a (-16.4,-0.6) | 0.038 | 2.3 (0, 4.7) |  > 0.05 |
 New York | 57,216 | 15.7 (15.5,15.8) | 14.0 | 30.0 | 30.2 | 27.2 | 2000–2003 | 4.4 (-0.4, 9.3) | 0.068 | 2003–2008 | 12.1a (9.6, 14.8) |  < 0.001 | 3.9a (2.8, 5.1) |  < 0.05 |
|  |  |  |  |  |  |  | 2008–2013 | 2.6a (0.7, 4.6) | 0.015 | 2013–2017 | -4.2a (-5.9, -2.4) | 0.001 |  |  |
 North Carolina | 18,409 | 10.6 (10.5,10.8) | 9.4 | 21.6 | 20.0 | 17.4 | 2000–2003 | 2.0 (-14.7, 22.1) | 0.798 | 2003–2006 | 26.8 (-5.3, 69.8) | 0.096 | 3.8 (-1.6, 9.5) |  > 0.05 |
|  |  |  |  |  |  |  | 2006–2013 | 2.4 (-1.3, 6.3) | 0.172 | 2013–2017 | -7.4a (-13.2,-1.2) | 0.027 |  |  |
 Pennsylvania | 41,361 | 17.1 (17.0,17.3) | 14.9 | 33.2 | 29.2 | 26.5 | 2000–2010 | 8.2a (7.1, 9.2) |  < 0.001 | 2010–2017 | -3.4a (-4.7, -2.2) |  < 0.001 | 3.2a (2.5, 3.9) |  < 0.05 |
 Rhode Island | 3220 | 16.1 (15.5,16.7) | 12.2 | 32.5 | 26.5 | 24.3 | 2000–2010 | 10.8a (7.5, 14.2) |  < 0.001 | 2010–2017 | -4.8a (-8.6, -0.9) | 0.020 | 4.1a (1.8, 6.4) |  < 0.05 |
 South Carolina | 8117 | 9.5 (9.3, 9.7) | 10.1 | 17.8 | 21.0 | 17.0 | 2000–2012 | 7.7a (6.6, 8.7) |  < 0.001 | 2012–2017 | -4.0a (-6.6, -1.3) | 0.007 | 4.1a (3.1, 5.1) |  < 0.05 |
 Texas | 46,306 | 10.8 (10.7,10.9) | 11.7 | 23.3 | 20.9 | 19.2 | 2000–2006 | 10.1a (7.3, 12.9) |  < 0.001 | 2006–2011 | 3.2 (-0.3, 6.9) | 0.070 | 3.2a (1.9, 4.5) |  < 0.05 |
|  |  |  |  |  |  |  | 2011–2017 | -3.3a (-4.8, -1.8) | 0.001 |  |  |  |  |  |