Association between total and leisure time physical activity and risk of myocardial infarction and stroke – a Swedish cohort study

Table 4 Incidence rates and hazard ratios of myocardial infarction for leisure time physical activity

Sex-specific tertiles of leisure time physical activity (METh/day)	Continuous (per 1METh/day increase)	Low	Medium	High	P for linear trend
Male		0–1.6	> 1.6–3.6	> 3.6–16.3
Female		0–1.5	> 1.5–3.1	> 3.1–16.3
Total
Myocardial infarction
Number of events		428	404	250
Person-years (py)		148,444	145,680	147,299
Event rate per 100,000 py^a		288.3	277.3	169.7
HR (95% CI)^a	0.96 (0.94–0.99)	1.00 (reference)	0.88 (0.77–1.01)	0.75 (0.64–0.87)	0.00
HR (95% CI)^b	0.98 (0.95–1.01)	1.00 (reference)	0.92 (0.79–1.06)	0.81 (0.68–0.95)	0.01
HR (95% CI)^c	0.97 (0.94–1.01)	1.00 (reference)	0.89 (0.76–1.03)	0.79 (0.66–0.94)	0.01
Male
Myocardial infarction
Number of events		234	239	143
Person-years		47,753	46,096	47,342
Event rate per 100,000 py^a		490.0	518.5	302.1
HR (95% CI)^a	0.98 (0.95–1.01)	1.00 (reference)	0.92 (0.77–1.11)	0.76 (0.61–0.93)	0.01
HR (95% CI)^b	0.99 (0.96–1.03)	1.00 (reference)	0.96 (0.79–1.17)	0.80 (0.64–1.00)	0.04
HR (95% CI)^c	0.99 (0.96–1.03)	1.00 (reference)	0.96 (0.78–1.17)	0.78 (0.62–0.98)	0.03
Female
Myocardial infarction
Number of events		194	165	107
Person-years		100,691	99,584	99,957
Event rate per 100,000 py^a		192.7	165.7	107.0
HR (95% CI)^a	0.92 (0.87–0.97)	1.00 (reference)	0.83 (0.67–1.02)	0.74 (0.58–0.93)	0.01
HR (95% CI)^b	0.93 (0.88–0.99)	1.00 (reference)	0.86 (0.68–1.07)	0.82 (0.64–1.06)	0.14
HR (95% CI)^c	0.92 (0.87–0.98)	1.00 (reference)	0.80 (0.63–1.01)	0.80 (0.61–1.04)	0.10

HR Hazard ratio, CI Confidence interval, PY Person-years
^aAdjusted for age and sex at enrollment
^bAdjusted for age, cigarette smoking, alcohol consumption, level of education, and body mass index
^cAdjusted for age, cigarette smoking, alcohol consumption, level of education, body mass index, hypertension, diabetes, and lipid disturbance

ISSN: 1471-2458