Table 1 Age standardized incidence, mortality, and 1-MIR rates per 100,000 individuals as well as LGCM results stratified by gender and super- region, 1990–2019

Incidence

Female

2.03(1.95,2.11)

1.99(1.92,2.07)

1.96(1.88,2.03)

2.37(2.27,2.47)

2.43(2.33,2.53)

2.38(2.16,2.64)

3.58^*

0.08^**

Male

4.13(3.99,4.6)

4.44(4.29,4.58)

4.46(4.34,4.57)

5.31(5.15,5.45)

5.58(5.39,5.77)

5.44(4.79,6.07)

8.31^*

0.11^**

Both

2.84(2.74,2.92)

2.97(2.87,3.06)

2.96(2.88,3.04)

3.57(3.45,3.68)

3.73(3.60,3.85)

3.65(3.33,3.98)

5.62^*

0.09^**

CEEECA

Mortality

Female

2.15(2.06,2.24)

2.07(1.99,2.13)

2.02(1.94,2.10)

2.49(2.38,2.59)

2.51(2.38,2.60)

2.45(2.21,2.69)

3.68^***

0.11^*

Male

4.33(4.17,4.46)

4.55(4.42,4.68)

4.56(4.43,4.68)

5.53(5.33,5.71)

5.62(5.42,5.80)

5.55(4.90,6.24)

8.62^*

0.15^*

Both

2.98(2.86,3.06)

3.03(2.94,3.11)

3.02(2.93,3.10)

3.71(3.57,3.82)

3.77(3.63,3.87)

3.72(3.39,4.07)

5.76^*

0.12^*

1-MIR

Female

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

–

–

Male

0.00(0.00,0.00)

0.004(0,0.008)

0.002(0,0.003)

0.00(0.00,0.00)

0.006(0.005,0.007)

0.00(0.00,0.00)

0.005^*

0.001^**

Both

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

–

–

Incidence

Female

2.50(2.37,2.59)

3.25(3.04,3.38)

3.94(3.64,4.10)

3.99(3.62,4.18)

3.87(3.47,4.09)

3.82(3.35,4.25)

2.25^***

−0.08^***

Male

7.79(7.59,7.95)

9.96(9.67,10.20)

11.74(11.39,11.97)

11.76(11.29,12.09)

11.32(10.78,11.66)

11.20(10.05,12.50)

5.63^***

−0.15^***

Both

4.88(4.74,4.99)

6.29(6.05,6.45)

7.51(7.20,7.68)

7.58(7.17,7.81)

7.33(6.90,7.58)

7.27(6.55,8.01)

3.78^***

−0.10^***

HI

Mortality

Female

2.32(2.18,2.40)

2.88(2.68,2.98)

3.38(3.10,3.52)

3.30(2.96,3.48)

3.19(2.82,3.37)

3.14(2.78,3.35)

2.21^***

−0.05^***

Male

6.94(6.76,7.10)

8.60(8.33,8.78)

9.68(9.36,9.90)

9.17(8.76,9.46)

8.68(8.25,8.95)

8.55(7.94,8.97)

5.37^***

−0.09^***

Both

4.38(4.23,4.48)

5.44(5.20,5.56)

6.24(5.94,6.40)

5.98(5.61,6.18)

5.71(5.31,5.91)

5.65(5.23,5.95)

3.63^***

−0.08^***

1-MIR

Female

0.04(0.03,0.06)

0.09(0.08,0.10)

0.10(0.12,0.11)

0.13(0.11,0.14)

0.13(0.14,0.15)

0.12(0.11,0.16)

0.12^***

0.002^***

Male

0.11(0.10,0.12)

0.13(0.11,0.14)

0.17(0.16,0.18)

0.22(0.21,0.23)

0.22(0.20,0.23)

0.22(0.19,0.26)

0.16^***

0.003^***

Both

0.09(0.08,0.10)

0.12(0.11,0.13)

0.15(0.15,0.17)

0.19(0.18,0.20)

0.19(0.17,0.20)

0.19(0.18,0.22)

0.15^***

0.002^***

Incidence

Female

3.00(2.84,3.17)

2.65(2.51,2.76)

2.13(2.02,2.22)

2.18(2.06,2.27)

2.27(2.12,2.38)

2.26(2.03,2.51)

2.11^***

0.01^*

Male

3.61(3.41,3.81)

3.32(3.14,3.49)

2.95(2.76,3.11)

3.28(3.09,3.45)

3.66(3.47,3.82)

3.72(3.37,4.14)

3.40^***

0.03^*

Both

3.30(3.14,3.43)

2.97(2.83,3.07)

2.52(2.38,2.63)

2.69(2.54,2.82)

2.91(2.75,3.03)

2.93(2.66,3.27)

2.46^***

0.02^*

LAC

Mortality

Female

3.23(3.03,3.40)

2.81(2.65,2.94)

2.29(2.14,2.39)

2.30(2.15,2.42)

2.43(2.27,2.54)

2.40(2.16,2.67)

2.41^***

0.07^**

Male

3.84(3.61,4.05)

3.50(3.30,3.69)

3.16(2.96,3.35)

3.45(3.22,3.64)

3.88(3.66,4.06)

3.95(3.57,4.38)

3.28^***

0.11^*

Both

3.52(3.33,3.67)

3.14(2.97,3.27)

2.70(2.53,2.82)

2.83(2.65,2.97)

3.09(2.92,3.22)

3.11(2.82,3.44)

2.86^***

0.09^*

1-MIR

Female

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

–

–

Male

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

–

–

Both

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

–

–

Incidence

Female

3.92(3.12,4.81)

3.68(3.19,4.20)

3.42(3.13,3.73)

3.87(3.55,4.23)

4.17(3.76,4.75)

4.10(3.44,4.97)

3.93^***

0.01^**

Male

8.18(7.08,9.30)

7.78(7.05,8.58)

7.79(7.27,8.33)

8.68(8.03,9.42)

8.93(7.84,10.22)

8.40(6.60,10.63)

6.46^***

0.03^**

Both

6.08(5.28,6.81)

5.76(5.24,6.25)

5.64(5.29,5.99)

6.31(5.91,6.81)

6.59(5.93,7.42)

6.29(5.13,7.71)

5.30^***

0.02^**

NAME

Mortality

Female

4.13(3.28,5.12)

3.83(3.27,4.43)

3.61(3.28,3.93)

3.87(3.51,4.24)

3.95(3.55,4.45)

3.69(3.10,4.51)

4.30^***

−0.001^**

Male

8.62(7.48,9.79)

8.18(7.39,9.08)

8.41(7.76,9.07)

8.67(8.00,9.38)

9.16(8.12,10.28)

8.63(6.81,10.83)

7.06^***

−0.003^**

Both

6.39(5.55,7.19)

6.03(5.47,6.55)

6.04(5.62,6.42)

6.31(5.90,6.74)

6.59(5.99,7.31)

6.20(5.06,7.62)

5.79^***

−0.003^**

1-MIR

Female

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.04(0.05,0.04)

0.09(0.09,0.10)

0.13(0.13,0.12)

−0.007^***

0.001^**

Male

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.02(0.02,0.03)

0.00(0.00,0.02)

0.00(0.00,0.00)

0.004^***

0.007^**

Both

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.03(0.03,0.04)

0.03(0.02,0.04)

0.04(0.04,0.04)

−0.005^*

0.003^*

Incidence

Female

1.96(1.54,2.45)

2.01(1.58,2.44)

2.05(1.65,2.43)

2.00(1.63,2.34)

1.98(1.67,2.29)

1.95(1.54,2.47)

–

–

Male

3.29(2.64,3.91)

3.38(2.75,3.88)

3.52(2.96,3.91)

3.53(3.04,3.87)

3.45(3.13,3.76)

3.38(2.86,3.99)

–

–

Both

2.66(2.20,3.08)

2.72(2.25,3.09)

2.79(2.37,3.11)

2.77(2.37,3.04)

2.70(2.42,2.94)

2.66(2.30,3.05)

–

–

SA^a

Mortality

Female

2.13(1.66,2.70)

2.18(1.74,2.67)

2.25(1.80,2.66)

2.22(1.82,2.59)

2.08(1.74,2.44)

2.09(1.61,2.67)

–

–

Male

3.46(2.78,4.07)

3.61(2.93,4.13)

3.74(3.13,4.19)

3.78(3.27,4.18)

3.59(3.28,3.92)

3.56(2.98,4.18)

–

–

Both

2.82(2.33,3.27)

2.92(2.44,3.32)

3.01(2.54,3.35)

3.00(2.59,3.30)

2.82(2.56,3.09)

2.81(2.43,3.24)

–

–

1-MIR

Female

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

–

–

Male

0.00(0.00,0.01)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

–

–

Both

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

–

–

Incidence

Female

12.17(10.133,14.70)

12.18(10.91,13.77)

8.39(7.78,9.18)

5.17(4.79,5.58)

4.75(4.30,5.20)

4.75(3.97,5.61)

6.11^***

−0.05^***

Male

29.69(24.58,35.49)

33.06(30.15,36.51)

23.46(21.73,25.32)

13.61(12.66,14.74)

13.85(12.57,15.34)

14.66(12.12,17.59)

12.63^***

−0.10^*

Both

20.85(17.91,24.30)

22.50(20.94,24.41)

15.77(14.85,16.83)

9.27(8.71,9.98)

9.14(8.44,9.89)

9.52(8.19,11.01)

9.35^***

−0.09^*

SAEAO

Mortality

Female

12.70(10.53,15.36)

12.69(11.24,14.47)

8.10(7.25,9.15)

5.36(4.92,5.82)

4.73(4.27,5.22)

4.67(3.93,5.52)

6.38^***

−0.07^***

Male

29.87(24.72,35.64)

33.42(30.05,37.20)

21.42(19.21,23.77)

13.61(12.49,14.79)

12.89(11.35,14.40)

13.40(11.17,15.84)

13.05^***

−0.05^***

Both

21.13(18.37,24.44)

22.84(20.90,24.88)

14.56(13.37,15.89)

9.31(8.67,9.97)

8.61(7.84,9.43)

8.82(7.65,10.09)

9.60^***

−0.05^*

1-MIR

Female

0.00(0.00,0.00)

0.00(0.00,0.00)

0.06(0.04,0.08)

0.00(0.00,0.00)

0.02(0.01,0.03)

0.03(0.02,0.04)

0.006

–

Male

0.03(0.01,0.05)

0.02(0.01,0.04)

0.15(0.12,0.18)

0.04(0.03,0.06)

0.13(0.10,0.15)

0.11(0.09,0.12)

0.01

–

Both

0.02(0.01,0.04)

0.03(0.01,0.05)

0.11(0.08,0.13)

0.03(0.02,0.05)

0.10(0.08,0.12)

0.09(0.08,0.10)

0.01

–

Incidence

Female

3.31(2.83,3.95)

3.40(2.94,3.93)

3.37(2.94,3.84)

3.17(2.78,3.54)

3.06(2.69,3.43)

2.90(2.52,3.31)

3.73^*

−0.002^*

Male

5.61(4.57,7.59)

6.68(5.99,7.60)

6.88(6.19,7.66)

6.34(5.73,7.00)

6.05(5.47,6.67)

5.75(5.09,6.46)

8.14^***

−0.03^*

Both

4.43(3.77,5.54)

4.99(4.49,5.52)

5.05(4.57,5.59)

4.67(4.24,5.11)

4.45(4.05,4.89)

4.22(3.77,4.71)

5.90^***

−0.01^*

SSA

Mortality

Female

3.54(3.05,4.22)

3.63(3.16,4.17)

3.55(3.07,4.05)

3.37(2.95,3.76)

3.30(2.89,3.70)

3.13(2.72,3.59)

3.85^***

−0.02^***

Male

6.01(4.91,8.14)

7.29(6.55,8.28)

7.41(6.58,8.32)

6.80(6.08,7.54)

6.54(5.88,7.20)

6.19(5.46,6.91)

10.56^***

−0.05^*

Both

4.73(4.01,5.93)

5.38(4.83,5.96)

5.38(4.83,5.99)

4.98(4.49,5.48)

4.80(4.35,5.26)

4.53(4.03,5.04)

5.95^***

−0.03^*

1-MIR

Female

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

–

–

Male

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

–

–

Both

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

0.00(0.00,0.00)

–

–

Incidence

Female

5.22(4.62,5.96)

5.55(5.14,6.04)

4.69(4.40,4.95)

3.80(3.56,3.98)

3.66(3.40,3.87)

3.63(3.23,4.05)

3.99^***

−0. 03^***

Male

13.07(11.42,14.87)

15.02(14.06,16.16)

12.63(12.02,13.26)

9.60(9.18,10.06)

9.59(9.07,10.11)

9.71(8.69,10.84)

7.91^***

−0. 08^*

Both

8.98(8.10,9.97)

10.09(9.56,10.70)

8.47(8.10,8.84)

6.55(6.25,6.82)

6.47(6.11,6.77)

6.51(5.95,7.16)

5.83^***

−0. 07^*

Global

Mortality

Female

5.33(4.67,6.09)

5.59(5.15,6.11)

4.47(4.15,4.80)

3.72(3.44,3.91)

3.51(3.22,3.74)

3.46(3.08,3.83)

4.17^***

−0. 02^***

Male

12.90(11.30,14.67)

14.76(13.65,15.99)

11.48(10.70,12.29)

9.00(8.55,9.45)

8.66(8.10,9.22)

8.73(7.88,9.60)

8.14^***

−0. 07^*

Both

8.93(8.09,9.90)

9.95(9.32,10.60)

7.78(7.35,8.20)

6.20(5.87,6.46)

5.93(5.59,6.24)

5.95(5.44,6.44)

6.03^***

−0. 06^*

1-MIR

Female

0.00(0.00,0.00)

0.01(0.00,0.03)

0.07(0.05,0.09)

0.04(0.03,0.06)

0.05(0.05,0.03)

0.04(0.02,0.05)

0.006

0.01^*

Male

0.04(0.02,0.05)

0.05(0.04,0.07)

0.11(0.09,0.13)

0.09(0.08,0.11)

0.11(0.10,0.13)

0.11(0.10,0.13)

0.01

0.01^*

Both

0.02(0.01,0.03)

0.04(0.03,0.07)

0.09(0.08,0.11)

0.07(0.06,0.09)

0.09(0.06,0.10)

0.09(0.07,0.11)

0.01

0.01^*