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Table 2 Pooled Association Between Highest versus Lowest Sedentary Time Duration and CVD Risks

From: Sedentary time and its association with risk of cardiovascular diseases in adults: an updated systematic review and meta-analysis of observational studies

Type of Sedentary Time Median duration of sedentary time, h/d CVD outcomes Pooled HR/RR [95% CI], P value Heterogeneity test (I2 and P value) Included Studies
Total sedentary time Highest: 10.5
Lowest: 2.75
CVD morbidity 1.24 [1.21, 1.27]
P<0.05
I2 = 0%, P = 0.42 Liu, 2020 [13]; Park 2021 [14]
Highest: 10.2
Lowest: 2.98
CVD mortality 1.29 [1.13, 1.47]
P<0.05
I2 = 35%, P = 0.20 Liu, 2020 [13]; Stamatakis, 2019 [15]; Dohrn, 2017 [16]; Evenson, 2016 [17]
Highest: 5
Lowest: 1
CVD morbidity and mortality 1.29 [0.93, 1.80]
P = 0.13
I2 = 69%, P = 0.04 Tu, 2020 [18]; Bellettiere, 2019 [19]; Borodulin, 2015 [20]
Screen time Highest: 3.75
Lowest: 1
CVD morbidity 1.03 [0.99, 1.07]
P = 0.21
I2 = 95%, P<0.001 Garcia, 2019 [21]; Morales, 2018 [9]; Cumming, 2017 [22]; McDonnell, 2016 [23]
Highest: 5
Lowest: 1
CVD morbiditya 1.22 [0.98, 1.52]
P = 0.07
I2 = 0%, P = 0.35 Garcia, 2019 [21]; McDonnell, 2016 [23]
Highest: 5
Lowest: 1
CVD morbidityb 1.04 [1.03, 1.05]
P<0.05
I2 = 32%, P = 0.23 Garcia, 2019 [21]; Morales, 2018 [9]; McDonnell, 2016 [23]
Highest: 5
Lowest: 1
CVD mortality 1.27 [1.05, 1.52]
P = 0.01
I2 = 87%, P<0.001 Hamer, 2020 [11]; Evenson, 2016 [17]; Grace, 2016 [24]; Ikehara, 2015 [25]; Keadle, 2015 [7]
Highest: 6
Lowest: 1
CVD mortalityb 1.36 [1.03, 1.78]
P<0.05
I2 = 80%, P = 0.002 Evenson, 2016 [17]; Grace, 2016 [24]; Ikehara, 2015 [25]; Keadle, 2015 [7]
  1. aResults of sensitivity analysis
  2. bIn these meta-analysis, studies which did not include any physical activity intensity in the most adjusted models as a covariate were excluded