Table 2 General characteristics of study patients with Influenza-associated hospitalization in Germany, January 2010 - December 2019
Age, years | |||||
|---|---|---|---|---|---|
All | <18 | 18-59 | >59 | p-value a | |
All cases, N (%) | 156,097 (100) | 47,982 (100) | 34,829 (100) | 73,286 (100) | |
Age, median (IQR) | 56 (9; 77) | 3 (1; 7) | 46 (33; 54) | 78 (70; 84) | <0.001 |
Age, mean (±SD) | 47.2 (± 32.5) | 4.8 (± 4.8) | 42.9 (± 12.2) | 77.1 (± 8.9) | <0.001 |
Sex | |||||
Female, N (%) | 75,609 (48.4) | 21,752 (45.3) | 16,868 (48.4) | 36,989 (50.5) | <0.001 |
Selected Risk Factors, N(%) | |||||
Pregnancy | 423 (0.3) | 7 (0.0) | 416 (1.2) | 0 (0.0) | <0.001 |
Diabetes | 23,465 (15.0) | 148 (0.3) | 3,046 (8.7) | 20,271 (27.7) | <0.001 |
Adiposity | 5,089 (3.3) | 197 (0.4) | 1,755 (5.0) | 3,137 (4.3) | <0.001 |
Immune disorder | 8,791 (5.6) | 582 (1.2) | 2,875 (8.3) | 5,334 (7.3) | <0.001 |
Influenza-associated ICD-10-GM codes, N(%) | |||||
Influenza due to identified zoonotic or pandemic Influenza virus (J09) | 25,226 (16.2) | 8,443 (17.6) | 7,947 (22.8) | 8,836 (12.1) | <0.001 |
Influenza due to identified seasonal Influenza virus (J10) | 131,989 (84.6) | 39,879 (83.1) | 27,217 (78.1) | 64,893 (88.5) | <0.001 |
Influenza with pneumonia, seasonal Influenza virus identified (J10.0) | 37,811 (24.2) | 6,691 (13.9) | 6,885 (19.8) | 24,235 (33.1) | <0.001 |
Influenza with other respiratory manifestations, seasonal Influenza virus identified (J10.1) | 79,765 (51.1) | 27,953 (58.3) | 16,936 (48.6) | 34,876 (47.6) | <0.001 |
Influenza with other manifestations, seasonal Influenza virus identified (J10.8) | 15,516 (9.9) | 5,477 (11.4) | 3,588 (10.3) | 6,451 (8.8) | <0.001 |
Influenza, virus not identified (J11)b | 889 (0.6) | 225 (0.5) | 243 (0.7) | 421 (0.6) | <0.001 |
Influenza with pneumonia, seasonal Iinfluenza virus not identified (J11.0)b | 176 (0.1) | 35 (0.1) | 59 (0.2) | 82 (0.1) | <0.001 |
Influenza with other respiratory manifestations, seasonal Influenza virus not identified (J11.1)b | 611 (0.4) | 151 (0.3) | 159 (0.5) | 301 (0.4) | 0.003 |
Influenza with other manifestations, seasonal Influenza virus not identified (J11.8)b | 107 (0.1) | 40 (0.1) | 27 (0.1) | 40 (0.1) | 0.133 |
Influenza A/H1N1 pandemic 2009 (U69.20)b | 8,160 (5.2) | 2,835 (5.9) | 3,219 (9.2) | 2,106 (2.9) | <0.001 |
Selected Complications, N(%) | |||||
Bronchitis, Influenza | 5,982 (3.8) | 1,575 (3.3) | 1,272 (3.7) | 3,135 (4.3) | <0.001 |
Pneumonia, Influenza | 37,898 (24.3) | 6,712 (14.0) | 6,926 (19.9) | 24,260 (33.1) | <0.001 |
Pneumonia, other viral | 476 (0.3) | 186 (0.4) | 126 (0.4) | 164 (0.2) | <0.001 |
Pneumonia, bacterial | 9,773 (6.3) | 1,277 (2.7) | 2,551 (7.3) | 5,945 (8.1) | <0.001 |
Myocarditis | 383 (0.2) | 57 (0.1) | 173 (0.5) | 153 (0.2) | <0.001 |
Encephalitis | 224 (0.1) | 104 (0.2) | 65 (0.2) | 55 (0.1) | <0.001 |
ARDS | 1,889 (1.2) | 92 (0.2) | 1,004 (2.9) | 793 (1.1) | <0.001 |
Sepsis | 3,590 (2.3) | 112 (0.2) | 1,133 (3.3) | 2,345 (3.2) | <0.001 |
Otitis Media | 2,909 (1.9) | 2,644 (5.5) | 160 (0.5) | 105 (0.1) | <0.001 |
Treatment/Outcome, N(%) | |||||
Intensive care | 9,513 (6.1) | 746 (1.6) | 2,918 (8.4) | 5,849 (8.0) | <0.001 |
ECMO | 540 (0.3) | 19 (0.0) | 361 (1.0) | 160 (0.2) | <0.001 |
Pre-ECMO | 36 (0.0) | XXX | XXX | XXX | |
PECLA | 49 (0.0) | XXX | XXX | XXX | |
Minimized heart-lung machine | 50 (0.0) | XXX | XXX | XXX | |
Veno-venous extracorporeal CO2 removal | 5 (0.0) | XXX | XXX | XXX | |
Fatality | 5,411 (3.5) | 86 (0.2) | 625 (1.8) | 4,700 (6.4) | <0.001 |
Hospital stay in days, median (IQR) | 5 (3; 7) | 3 (2; 4) | 4 (2; 4) | 7 (4; 10) | <0.001 |