Table 1 Summary of PRINCESSE healthcare package per protocol visit
Time since inclusion (MO) W: week/M: month | M0 | W2 | M3 | M6 | M9 | M12 | M15 | M18 | M21 | M24 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
Initial screening (at inclusion) | HIV testing | ✓ | |||||||||
HBsAg testing | ✓ | ||||||||||
HIV prevention (if HIV-) | HIV testing | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
Creatinine (if PrEP) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
HIV PrEP (TDF/FTC) (if eligible) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
At PrEP interruption (if AgHBs + or isolated HBcAb) | ALAT/ASAT (every 3 months) + HBV viral load if sign of hepatitis B reactivation | ||||||||||
HIV post-exposure prophylaxis | when needed | ||||||||||
HIV care (if HIV+) | Antiretroviral treatment | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
CD4 and viral load (if HIV+) | ✓ | ✓ | ✓ | ✓ | ✓ | ||||||
HBV prevention (if HBsAg-) | HBsAb testing | ✓ | |||||||||
HBcAb testing | ✓ | ||||||||||
HBV vaccination (if HBsAb- et HBcAb-) | 3 × 1 doses if HIV- (M0, M1, M6), 4 × 2 doses if HIV+ (M0, M1, M2, M6) | ||||||||||
HBV care (if HBsAg+) | HBeAg testing | ✓ | |||||||||
Creatinine (if on TDF) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
ALT/AST/Platelets | ✓ | ✓ | ✓ | ✓ | ✓ | ||||||
Antiretroviral treatment (TDF/FTC) (according to FIB-4 level and creatinine clearance level) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
HBV viral load | ✓ | ✓ | ✓ | ||||||||
STI screening and care | Syndromic STI screening | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
Systematic STI testing (Chlamydia PCR + Gonorrhea PCR + Syphilis rapid test) | ✓ | ✓ | ✓ | ||||||||
Dysplasia testing (+ treatment when necessary) | ✓ | ✓ | ✓ | ||||||||
STI treatment | when needed | ||||||||||
Pregnancy screening and contraception | Pregnancy test | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
Contraception (pills, injection or implant according to patient’s choice) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||
Emergency pill | when needed | ||||||||||
Other | Condom and lubricating gel | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
Identification of addiction (tobacco, alcohol, drugs) and referencing when necessary | ✓ | ✓ | ✓ | ✓ | |||||||