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Table 1 Model parameters

From: Targeting screening and treatment for latent tuberculosis infection towards asylum seekers from high-incidence countries – a model-based cost-effectiveness analysis

DESCRIPTION MEAN VALUE UNCERTAINTY INTERVAL SOURCE PROBABILITY
DISTRIBUTION
Epidemiological & treatment parameters
 Prevalence of LTBI at entry Varying* [14, 23,24,25]
 Sensitivity of IGRA 0.800 0.750–0.840 [31] beta
 Specificity of IGRA 0.980 0.870–0.990 [32] beta
 Probability of TPT initiation 0.700 0.600–0.800 [24, 26, 33] uniform
 Probability of TPT completion 0.700 0.600–0.800 [33] uniform
 Probability of reactivation of untreated LTBI 0.053 0.025–0.080 [11, 27, 28] uniform
 Effectiveness of complete TPT 0.660 0.430–0.890 [29] uniform
 Effectiveness of incomplete TPT 0.250 0.150–0.350 Assumption uniform
 Effectiveness of TPT for rifampicin-resistant LTBI 0 Assumption
 Probability of TPT drug-toxicity events not requiring hospitalization 0.020 0.010–0.030 [35, 36] beta
 Probability of TPT drug-toxicity events requiring hospitalization 0.0003 0.0001–0.0006 [36] beta
Cost parameters
 Cost for performing IGRA incl. Laboratory fees (€) 47.03 37.62–56.43 [37] uniform
 Cost for counselling an IGRA-positive individual for TPT (€) 27.34 21.87–32.80 [37] uniform
 Cost for physician consultation during TPT (fee for 2 quarters of a year; €) 34.72 27.78–41.67 [37] uniform
 Cost for laboratory tests prior to and during TPT (€) 16.18 12.95–19.42 [37] uniform
 Cost for 4-months of rifampicin-based TPT (€) 330.39 322.91–337.87 [37, 38] uniform
 Factor for discounting cost for incomplete TPT 0.375 0.250–0.500 [35] uniform
 In-patient management of drug adverse events of TPT (€) 2553.10 1702.07 – 3404.13 [39] uniform
 Average costs for managing TB disease (€) 8947.65 7158.12 - 10,737.17 [37] uniform
Quality-of-life weights
 Active TB 0.67   [40,41,42,43]
 LTBI 1.00   N/A
 TPT-related drug toxicity not requiring hospitalization 0.75   [44,45,46]
 TPT-related drug toxicity requiring hospitalization 0.50   [44, 47]
Other parameters
 Average age at immigration 24   [17]
 Life expectancy at immigration (years) 59   Estimated from [48]
 Average time to LTBI reactivation (years) 7.0 6.0–8.0 Estimated from [11] uniform
 TB case-fatality ratio 0.015 0.010–0.020 Estimated from program data uniform
  1. * Modelled using results from observational studies (see main text)