Table 1 Model parameters

 Prevalence of LTBI at entry

Varying^*

–

[14, 23,24,25]

–

 Sensitivity of IGRA

0.800

0.750–0.840

[31]

beta

 Specificity of IGRA

0.980

0.870–0.990

[32]

beta

 Probability of TPT initiation

0.700

0.600–0.800

[24, 26, 33]

uniform

 Probability of TPT completion

0.700

0.600–0.800

[33]

uniform

 Probability of reactivation of untreated LTBI

0.053

0.025–0.080

[11, 27, 28]

uniform

 Effectiveness of complete TPT

0.660

0.430–0.890

[29]

uniform

 Effectiveness of incomplete TPT

0.250

0.150–0.350

Assumption

uniform

 Effectiveness of TPT for rifampicin-resistant LTBI

0

–

Assumption

–

 Probability of TPT drug-toxicity events not requiring hospitalization

0.020

0.010–0.030

[35, 36]

beta

 Probability of TPT drug-toxicity events requiring hospitalization

0.0003

0.0001–0.0006

[36]

beta

 Cost for performing IGRA incl. Laboratory fees (€)

47.03

37.62–56.43

[37]

uniform

 Cost for counselling an IGRA-positive individual for TPT (€)

27.34

21.87–32.80

[37]

uniform

 Cost for physician consultation during TPT (fee for 2 quarters of a year; €)

34.72

27.78–41.67

[37]

uniform

 Cost for laboratory tests prior to and during TPT (€)

16.18

12.95–19.42

[37]

uniform

 Cost for 4-months of rifampicin-based TPT (€)

330.39

322.91–337.87

[37, 38]

uniform

 Factor for discounting cost for incomplete TPT

0.375

0.250–0.500

[35]

uniform

 In-patient management of drug adverse events of TPT (€)

2553.10

1702.07 – 3404.13

[39]

uniform

 Average costs for managing TB disease (€)

8947.65

7158.12 - 10,737.17

[37]

uniform

 Active TB

0.67

[40,41,42,43]

–

 LTBI

1.00

N/A

–

 TPT-related drug toxicity not requiring hospitalization

0.75

[44,45,46]

–

 TPT-related drug toxicity requiring hospitalization

0.50

[44, 47]

–

 Average age at immigration

24

[17]

–

 Life expectancy at immigration (years)

59

Estimated from [48]

–

 Average time to LTBI reactivation (years)

7.0

6.0–8.0

Estimated from [11]

uniform

 TB case-fatality ratio

0.015

0.010–0.020

Estimated from program data

uniform