Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from China

Table 2 Age and multivariable adjusted hazard ratios (95%CI) for incidence of stroke by total pre-existing comorbidities

		Total pre-existing comorbidities						P trend
		0		1		≥ 2
		HR	95%CI	HR	95%CI	HR	95%CI
Total stroke	Cases/Population	53/6049		203/6555		193/3642
	Model 1	1.00	Referent	3.60	2.66, 4.87	6.28	4.62, 8.49	< 0.001
	Model 2	1.00	Referent	2.02	1.49, 2.74	3.04	2.24, 4.14	< 0.001
	Model 3	1.00	Referent	1.96	1.44, 2.67	2.87	2.09, 3.94	< 0.001
Ischemic stroke	Cases/Population	42/6049		167/6555		140/3642
	Model 1	1.00	Referent	3.47	2.47, 4.88	6.31	4.48, 8.87	< 0.001
	Model 2	1.00	Referent	1.93	1.37, 2.72	3.04	2.15, 4.29	< 0.001
	Model 3	1.00	Referent	1.87	1.32, 2.65	2.89	2.03, 4.12	< 0.001
Non-ischemic stroke	Cases/Population	12/6049		49/6555		37/3642
	Model 1	1.00	Referent	4.10	2.13, 7.90	6.11	3.13, 11.93	< 0.001
	Model 2	1.00	Referent	2.38	1.23, 4.60	3.06	1.56, 6.02	0.001
	Model 3	1.00	Referent	2.30	1.17, 4.47	2.80	1.39, 5.63	0.005

Model 1: unadjusted model; Model 2: adjusted for age and sex; Model 3: further adjusted for BMI, smoking and drinking status

ISSN: 1471-2458