Relationship between multimorbidity, disease cluster and all-cause mortality among older adults: a retrospective cohort analysis

Table 3 The most impactful LTCs combinations in stratified logistic regression analysis for mortality, for different multimorbidity categories (based on LTC count)

Categories	No. of deaths	No. of person-years	Mortality rate^a	Adjusted^b OR (95% CI)
2 LTCs (Total number of deaths N = 1146)
Hypertension + diabetes	570	26,753.84	21.31	1.89 (1.67,2.13)
Hypertension + CHD	416	21,575.80	19.28	1.44 (1.26,1.64)
Hypertension + stroke	58	1581.35	36.68	2.41 (1.75,3.32)
Hypertension + COPD	44	992.24	44.34	3.02 (2.12,4.31)
Diabetes + CHD	28	2162.11	12.95	1.15 (0.77,1.72)
CHD + COPD	11	312.92	35.15	2.02 (1.03,3.95)
Hypertension + Mental disorders	8	284.27	28.14	2.08 (0.92,4.70)
Diabetes + COPD	4	89.62	44.63	4.04 (1.29,12.71)
3 LTCs (Total number of deaths N = 279)
Hypertension + diabetes + CHD	188	8849.08	21.25	1.90 (1.59,2.27)
Hypertension + diabetes + stroke	29	660.92	43.88	3.48 (2.29,5.28)
Hypertension + stroke + CHD	17	652.11	26.07	2.09 (1.23,3.54)
Hypertension + CHD + COPD	17	477.75	35.58	2.57 (1.50,4.41)
Hypertension + diabetes + COPD	9	294.51	30.56	2.44 (1.16,5.11)
4 LTCs (Total number of deaths N = 18)
Hypertension + diabetes +stroke + CHD	9	274.78	32.75	3.18 (1.52,6.65)

All predictors entered individually in separate models using No LTC group as the reference category
LTCs Long-term conditions, CHD Coronary heart disease, COPD Chronic obstructive pulmonary disease, OR (95% CI) Odds ratio and 95% confidence interval
^aPer 1000 person-years; ^bAdjusted for age, sex, marital status, smoking status, alcohol status, physical activity, and body mass index (< 18.5, 18.5–24.9, 25–29.9, 30–34.9, 35–39.9 or ≥ 40) at baseline

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