Opioid use in medical cannabis authorization adult patients from 2013 to 2018: Alberta, Canada

BMC Public Health

Table 2 Interrupted time series of mean weekly OME differences per patient in medically authorized cannabis users (n = 5373) vs controls (n = 5373)

Variable	Weekly OME difference (95% CI)^a
Pre-incentive trend^b	18.7 (11.2 to 26.3)
Level change after medical cannabis authorization^c	−183.2 (−449.8 to 83.3)
Trend change after medical cannabis authorization^d	−18.1 (− 29.1 to − 7.2)
Overall absolute effect after medical cannabis authorization^e	−76.5 (− 308.0 to 154.9)

^aAll reported values indicate the average difference in weekly mean OME per patient in those who received a medical cannabis authorization compared to controls
^bRate of change in the outcome over time prior to medical cannabis authorization
^cImmediate change in outcome following medical cannabis authorization
^dweek to week change in mean OME or slope after medical cannabis authorization, relative to the pre-incentive difference in trend
^eThe overall absolute effect after medical cannabis authorization is the absolute difference in the weekly OME over the 26 weeks pre- and 52 weeks post-medical cannabis authorization period, compared to the counterfactual difference in trends had medical cannabis authorization not occurred (i.e. pre-incentive difference in trends projected forward)

ISSN: 1471-2458