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Table 4 Scenario analyses: optimal combination of Wolbachia and paediatric dengue vaccination coverage to minimize the number of dengue cases (and DALYs lost) – base-case budget constraint

From: Reducing dengue fever cases at the lowest budget: a constrained optimization approach applied to Thailand

Scenario Wolbachia (%) Paediatric vaccination (%) Cases (millions) DALYs lost Total costs (PP) ($millions)
Wolbachia cost (lower bounds) 100 71 1.073 10,143 368.820
Vaccine cost −50% 43 100 1.075 10,167 367.215
Unit cost profile [59] 45 64 1.161 10,979 368.916
80% vaccine efficacy 44 53 1.180 11,158 368.389
Societal perspective 51 43 1.206 11,399 368.846
Vaccine coverage 70–100% 22 70 1.216 11,500 368.680
50% vaccine efficacy 69 33 1.221 11,540 368.630
Vaccine cost + 50% 68 23 1.230 11,628 368.925
Wolbachia cost (upper bounds) 21 41 1.326 12,531 366.220
5-year follow-up 33 22 1.317 12,450 202.720
  1. DALY disability-adjusted life year, PP payer perspective