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Table 4 Characteristics of studies included in a systematic review of reviews for assessing the effect of prenatal depression on birth outcomes (N = 6)

From: Global burden of antenatal depression and its association with adverse birth outcomes: an umbrella review

Author, year

Geographic coverage of the review

Prominent tools used

Database searched

Number of studies and number of participants

Quality assessment tool used

Main findings relevant to our review

AMSTAR score

PTB

LBW

Ascort et al. 2014

Included studies conducted in the year from 1977 to 2013

USA, Europe, Asia

CES-D (19 studies)

PubMed and PsycINFO

- PTB = 50 studies with Sample size of 286,043

- LBW = 33 studies with sample size of 43,534

NOS

- Taking into account the methodological quality of studies, research on depression and PTB/GA is inconclusive at best

- Is a systematic review as pooling was not conducted

- It was found that about more than half (53%) of published LBW findings reported statistically significant associations with prenatal depression and low birth weight

- Was a systematic review as pooling was not conducted

8

Araujo et al. 2010

Included studies conducted in the year from 1996 to 2007

United States, Norway, Canada, Denmark, India, England, United Kingdom

Not found

PubMed, SciELO, and ISIWEB u

10 studies with sample size of 231,201

Downs & Black quality assessment check list

 

Depression during pregnancy was associated with low birth weight in seven studies

- Was a systematic review as pooling was not conducted

5

Grigoriadis S et al. 2013

Included studies conducted in the year from

1992 to 2010

most of the studies were in USA while few share Australia, China, Europe

CES-D at different cut of value in 11 studies

MEDLINE, EMBASE, CINAHL, Scopes and PsycINFO

- PTB = 15 studies with sample size of 23,754

- LBW = 6 studies with sample size of 14,090

Systematic Assessment of Quality in Observational Research (SAQOR) and the Newcastle-Ottawa Scale

- Preterm birth (PAOR = 1.37;

95% CI, 1.04 to 1.81)

- I2 = 61%

- No evidence of publication bias

- Low - birth weight was not significantly associated with prenatal depression (POR = 1.21; 95% CI, 0.91 to 1.60)

- I2 = 0.0%

- No evidence of publication bias

10

Grote K et al. 2010

Included studies conducted in the year from 1980 - 2009

most of the studies were from USA while the rest are from Europe, Asia, Brazil

CES-D in 10 studies

MEDLINE, PsycINFO, CINAHL, social work abstracts, social services abstracts, and dissertation Abstracts international databases

- PTB = 20 studies with sample of 29,295

- LBW = 11 studies with sample size of 13,544

Developed by modifying the instrument by Downs and Black

- Preterm birth is associated with depression during pregnancy

PRR = 1.39 [1.19–1.61]

- The association between antenatal depression and risk of PB was found to be higher in among women of lower socio-economic status in the United States.

- I2 = 61%

- Publication bias checked and corrected

- Low Birth Weight was associated with depression during pregnancy

PRR = 1.49 [1.25–1.77]

- The association between antenatal depression and risk of LBW was found to be higher in developing countries as compared to USA (RR = 2.05; 95% CI, 1.43–2.93)

- I2 = 70%

- Publication bias checked and corrected

7

Jarde A et al. 2016

Included studies conducted in the year from 1992 to 2015

most of the studies were from USA and other developed countries

DSM-IV (nine studies and CES-D (six studies)

MEDLINE, EMBASE, PsycINFO, cumulative index to nursing and allied health, Cochrane Central Register of Controlled Trials, and Web of Science.

- PTB = 14 studies

- LBW = 8 studies with sample size of 25,663

Newcastle-Ottawa Scale

Antenatal depression was associated with an increased risks of preterm birth (odds ratio [OR], 1.56; 95% CI, 1.25–1.94)

- I2 = 39%

Antenatal depression was associated with an increased risk of low birth weight (OR, 1.96; 95% CI, 1.24–3.10)

- I2 = 48%

10

Staneva A et al. 2015

Included studies conducted in the year from 1992 to 2015

The majority of studies (27) were from the USA, the remaining are from Europe, Brazil (2), Canada (1), UK (1), Norway (1), and China (1)

CES-D in six studies

MEDLINE, CINHAL, PsycInfo, and Cochrane databases and manual searches were performed through reference list of included studies

- 14 studies investigated the association between antenatal depression and PTB

- Sample size not clear

checklist developed by a knowledge synthesis group for the specific purpose of review of the evidence relating to determinants of preterm birth and low birth weight

- Preterm birth was independently and significantly predicted by antenatal depression

- Was a systematic review as pooling was not conducted

 

7

  1. Note: PTB Preterm birth LBW Low birth weight PRR Pooled relative risk POR Pooled odds ratio RR Relative risk OR Odds ratio