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Table 1 Measures Related to Primary Aims

From: Protocol for iGrow (Infant Growth and Development Study): biopsychosocial predictors of childhood obesity risk at 2 years

Domain

Construct

Srce

Measure

Timing

Aim 1

Aim2

Prenatal Psychobiological Risk

Weight Status

LR

Pre-pregnancy BMI

PreN

 

LR

Pregnancy weight gain

Pregnancy complications

LR

Pre-eclampsia

PreN

 

LR

Gestational diabetes

Insulin Resistance

LR

OGTT results

PreN

 

Hormonal risk

BIO

Leptin, Adiponectin, Insulin

PreN

 

Substance use

MR

Modified WHO ASSIST

PreN

 

Prenatal Stress

MR

CES-D, State-Trait Anxiety Inventory, Stressful Life Events Questionnaire

PreN

 

Infant Psychobiological Risk

HPA axis functioning

BIO

Cortisol reactivity-saliva

2 M

 

Cardiac functioning

BIO

Resting vagal tone

2 M

 

Negative emotionality

OBS

Irritability rating

2 M

 

MR

IBQ-VSF

2 M

 

Infant Hormonal Risk

Hormone levels

BIO

Leptin, Adiponectin, Insulin

2 M

 

Maternal Obesogenic Feeding Practices

Feeding Practices

MR

Infant Feeding Practices Q II

2 + 6 M

14 + 24 M

Infant Feeding Style Ques.

2 + 6 M

14 + 24 M

Feeding to Soothe Scale

2 + 6 M

14 + 24 M

Infant Food Frequency Questionnaire

 

14 + 24 M

Maternal Sensitivity

Feeding task

OBS

Sensitivity/responsive feeding ratings

2 + 6 M

14 + 24 M

Play task

OBS

Sensitivity ratings

2 + 6 M

14 + 24 M

Distressing task

OBS

Sensitivity ratings

2 + 6 M

14 + 24 M

Child Self-Regulation

Physiological

BIO

Vagal withdrawal to stressful tasks

 

14 + 24 M

Emotional

OBS

MR

Observed affect and regulatory behaviors during stressful tasks

IBQ/ECBQ VSF

 

14 + 24 M

Attentional

OBS MR

Fixation task

ECBQ VSF

 

14 + 24 M

Infant Weight Gain 0 to 6 Months

Change in WHO Weight-for- length z-score

MR

OBS

Weight/recumbent length

6 M – Birth

 

Obesity Risk 2Y

BMI-for-age z-score

OBS

Weight/heighta

 

24 M

Adiposity z-score

OBS

Skin foldsa

 

24 M

BODPOD (infant option)

 

24 M

Inflammatory markers

BIO

IL-6, TNF-α, CRPa

 

24 M

  1. OBS observed, BIO biological measure, LR official lab reports/Patient Portal, MR mother reported, PreN prenatal, M months; + = composite across time, − is a change score
  2. aTo be assessed at each time point for secondary analyses; timepoint related to primary aims is noted in table