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Table 2 Subdistribution hazard ratios (95 CIs) for the association between the number polypharmacy and hospitalization following a fall (N = 6220), England 2012–2018

From: Polypharmacy is a risk factor for hospital admission due to a fall: evidence from the English Longitudinal Study of Ageing

  Age and gender adjusted Fully adjusteda
Polypharmacy SHR (95%CI) P Value SHR (95%CI) P Value
No medications 1 (Ref)   1 (Ref)  
1–4 medications 2.06 (1.38; 3.07) < 0.0001 1.79 (1.18; 2.71) < 0.01
5–9 medications
(polypharmacy)
2.49 (1.62; 3.82) < 0.0001 1.75 (1.04; 2.95) < 0.05
10+ medications
(heightened polypharmacy)
5.79 (3.33; 10.1) < 0.0001 3.19 (1.61; 6.32) < 0.001
  1. Hospitalization following a fall N = 295, competing event deaths N = 594. aAdjusted for age, gender, living alone, education, poor vision, all diagnoses and health conditions, 3+ long-term conditions, 2+ FRIDs, any functional impairment, health behaviours, tests of cognitive function