Table 2 Study measures by study visit

 Locator information

X

X

X

 Sociodemographics: age, sex

X

 Socioeconomic factors: income, education, occupation, marital status, children

X

 Medical History: history of CVD risk factors, CVD, HIV, tuberculosis

X

 Family History: stroke or MI in parents and 4 oldest siblings

X

 Health status: Short Form questionnaire [50, 51]

X

 Medications: complete list taken in the last 2 weeks prescription, non-prescription, and herbal or traditional medicine

X

X

X

 Health behaviors: current tobacco smoking and number of pack years [48], alcohol (number of alcoholic beverages consumed per day and week using NIDA cutoffs by gender [52,53,54,55]), physical activity (WHO Global Physical Activity Questionnaire [56])

X

X

X

 Places lived

X

X

X

 Diet: WHO STEPS Diet Survey [48]

X

X

X

 Negative emotions: Depression (PHQ-9), Stress (Perceived Stress Scale-4) [57, 58]

X

X

 Health access/utilization: hospitalization and clinic visits

X

X

X

 Household demographics and socioeconomic factors: family size, dependents, family income, housing stability

X

 Household Food Insecurity: Short Form Household Food Security Scale [59]

X

X

 Social isolation: Multidimensional Scale of Perceived Social Support [60]

X

X

 Neighborhood stress and violence: Neighborhood Collective Efficacy [61, 62], City Stress Inventory [63, 64]

X

X

 Traditional medicine practices

X

X

 Water and Sanitation: clean water, indoor plumbing, latrine

X

 Electricity

X

 Indoor cooking and type of cooking

X

 Lead exposure history: lead paint, cookware, occupation

X

X

X

 Crowding: population density of neighborhood using IHSI census data [65]

X

 Physiologic measures: height, weight, waist circumference, left arm circumference

X

X

X

 Blood pressure (BP): every 6 months in clinic or community

X

X

X

X

X

 Electrocardiogram

X

X

 Echocardiogram: performed on participants with signs or symptoms of heart failure, MI, stroke, or hypertension and 300 participants without symptoms

X

X

 Biologic specimens: fasting blood, urine (albuminuria, cholesterol, creatinine, CRP, glucose, hemoglobin, HIV, lead level, lipids, white blood cells)

X

X

 Biobanked specimens: whole blood, plasma, serum, urine, stool sample at enrollment and only blood will be collected at 24 months.

X

X

 CVD symptoms and event screening: WHO Angina Questionnaire [66, 67], Questionnaire to Verify Stroke-free Status [67], and self-reported CVD events

X

X

X

 Medical record abstraction: diagnoses codes (ICD-9), laboratory measures, diagnostic imaging, and cause of death among participants who receive clinical care from the GHESKIO clinic, a GHESKIO-affiliated hospital, or other health facility