Table 3 Factors Associated With Pneumococcal VCR (CPRD; 2011–2015)

 18–49

Reference group

Reference group

 50–64

1.14 (1.10, 1.19)

P < 0.0001

0.96 (0.93, 1.00)

P = 0.051

 Male

Reference group

Reference group

 Female

0.96 (0.93, 1.00)

P = 0.033

0.91 (0.88, 0.95)

P < 0.0001

 North East

Reference group

 North West

1.64 (1.37, 1.97)

P < 0.0001

1.52 (1.27, 1.82)

P < 0.0001

 Yorkshire and the Humber

1.96 (1.59, 2.42)

P < 0.0001

1.98 (1.60, 2.44)

P < 0.0001

 East Midlands

1.60 (1.20, 2.13)

P = 0.001

1.49 (1.12, 1.99)

P = 0.006

 West Midlands

1.75 (1.46, 2.10)

P < 0.0001

1.66 (1.39, 2.00)

P < 0.0001

 East of England

1.60 (1.32, 1.93)

P < 0.0001

1.57 (1.30, 1.90)

P < 0.0001

 South West

1.46 (1.21, 1.75)

P < 0.0001

1.45 (1.21, 1.75)

P < 0.0001

 South Central

1.51 (1.25, 1.81)

P < 0.0001

1.48 (1.23, 1.77)

P < 0.0001

 London

1.37 (1.14, 1.65)

P = 0.0001

1.30 (1.08, 1.56)

P = 0.005

 South East Coast

1.36 (1.13, 1.64)

P = 0.001

1.34 (1.12, 1.61)

P = 0.002

 Northern Ireland

1.57 (1.30, 1.90)

P < 0.0001

1.38 (1.14, 1.68)

P = 0.001

 Scotland

1.98 (1.65, 2.37)

P < 0.0001

1.92 (1.61, 2.30)

P < 0.0001

 Wales

0.96 (0.80, 1.16)

P = 0.677

1.02 (0.85, 1.22)

P = 0.870

 Immunosuppression

Reference group

Reference group

 Cerebrospinal fluid leaks

0.52 (0.31, 0.86)

P = 0.01

0.77 (0.47, 1.29)

P = 0.322

 Chronic heart disease

0.91 (0.85, 0.97)

P = 0.006

0.71 (0.66, 0.76)

P < 0.0001

 Chronic kidney disease

0.63 (0.54, 0.74)

P < 0.0001

0.55 (0.46, 0.64)

P < 0.0001

 Chronic liver disease

0.53 (0.46, 0.62)

P < 0.0001

0.55 (0.47, 0.64)

P < 0.0001

 Chronic respiratory disease

1.05 (0.98, 1.11)

P = 0.181

0.86 (0.80, 0.91)

P < 0.0001

 Diabetes mellitus

1.09 (1.03, 1.16)

P = 0.004

0.82 (0.77, 0.88)

P < 0.0001

 No

Reference group

Reference group

 Yes

8.68 (8.11, 9.29)

P < 0.0001

8.78 (8.19, 9.40)

P < 0.0001