Table 5 Multivariable-adjusted mean changes in cardiovascular disease risk factors (95% CI) over 6 years of follow-up, according to quartiles of sedentary time and meeting guidelines for moderate-to-vigorous physical activity among men and women – No exclusions^a

0.59

0.99

0.68 (0.40, 0.95)

0.85 (0.63, 1.08)

0.74 (0.50, 0.98)

0.83 (0.56, 1.09)

0.73 (0.57, 0.90)

0.86 (0.65, 1.07)

0.60 (0.33, 0.87)

0.75 (0.42, 1.08)

0.32 (0.04, 0.60)

0.61 (0.33, 0.89)

0.51 (0.31, 0.70)

0.63 (0.40, 0.86)

0.08

0.79

1.52 (0.76, 2.28)

1.64 (0.88, 2.40)

1.92 (1.27, 2.57)

2.26 (1.49, 3.03)

1.87 (1.36, 2.38)

1.84 (1.30, 2.37)

3.12 (2.37, 3.88)

3.03 (2.16, 3.90)

1.64 (0.68, 2.59)

2.88 (2.02, 3.73)

2.64 (2.07, 3.22)

2.75 (2.09, 3.41)

0.43

0.67

−0.00 (−1.10, 1.09)

0.96 (−0.14, 2.05)

0.50 (− 0.67, 1.68)

0.58 (− 0.54, 1.70)

0.51 (− 0.22, 1.24)

0.60 (− 0.37, 1.57)

1.77 (0.59, 2.94)

1.88 (0.62, 3.13)

1.41 (0.08, 2.75)

0.48 (− 0.76, 1.72)

1.55 (0.46, 2.64)

1.28 (0.50, 2.06)

0.72

0.99

−0.49 (−1.36, 0.38)

0.40 (−0.38, 1.18)

− 0.21 (− 0.98, 0.55)

−0.48 (− 1.34, 0.38)

− 0.25 (− 0.79, 0.29)

−0.04 (− 0.79, 0.72)

0.58 (−0.31, 1.48)

0.64 (− 0.31, 1.59)

0.32 (− 0.76, 1.39)

−0.22 (− 1.24, 0.81)

0.22 (− 0.56, 1.00)

0.42 (− 0.24, 1.08)

0.34

0.15

−4.62 (−6.73, −2.51)

−4.48 (−6.54, −2.41)

−3.63 (−5.97, − 1.30)

−5.39 (−7.57, −3.20)

−3.74 (− 5.34, − 2.13)

−6.01 (− 7.96, − 4.05)

− 6.38 (−8.88, − 3.89)

−3.18 (− 6.77, 0.41)

−5.18 (− 8.34, − 2.02)

− 3.94 (− 7.07, − 0.82)

−5.03 (−7.15, − 2.91)

− 4.57 (− 6.75, − 2.39)

0.82

0.30

2.61 (1.67, 3.55)

2.02 (1.30, 2.75)

2.55 (1.64, 3.46)

1.82 (0.94, 2.71)

2.25 (1.68, 2.82)

2.18 (1.44, 2.92)

0.65 (− 0.33, 1.64)

0.58 (− 0.42, 1.58)

1.48 (0.38, 2.59)

0.49 (− 0.46, 1.43)

1.21 (0.47, 1.94)

0.45 (− 0.34, 1.25)

0.09

0.09

0.92 (0.88, 0.96)

0.91 (0.87, 0.95)

0.96 (0.92, 1.00)

0.95 (0.91, 0.99)

0.94 (0.91, 0.96)

0.93 (0.89, 0.97)

0.98 (0.93, 1.03)

0.95 (0.91, 1.00)

0.92 (0.87, 0.97)

0.95 (0.91, 1.00)

0.93 (0.89, 0.96)

0.97 (0.94, 1.01)

0.62

0.23

3.43 (2.04, 4.83)

3.55 (2.46, 4.64)

4.18 (2.78, 5.59)

4.90 (3.66, 6.14)

4.56 (3.68, 5.43)

3.06 (2.12, 4.00)

3.87 (2.54, 5.20)

4.70 (3.10, 6.31)

4.40 (2.96, 5.85)

4.22 (2.48, 5.97)

4.52 (3.37, 5.68)

4.11 (3.08, 5.14)

0.31

0.56

8.13 (4.59, 11.68)

9.00 (6.03, 11.97)

8.38 (5.11, 11.65)

13.24 (9.82, 16.66)

10.08 (8.02, 12.15)

8.91 (6.26, 11.57)

5.95 (2.61, 9.29)

7.40 (3.20, 11.59)

6.78 (1.31, 12.24)

6.13 (2.43, 9.83)

6.48 (3.54, 9.41)

6.65 (3.85, 9.46)

0.48

0.45

0.19 (0.15, 0.23)

0.18 (0.15, 0.21)

0.19 (0.15, 0.22)

0.17 (0.14, 0.20)

0.18 (0.16, 0.20)

0.19 (0.15, 0.22)

0.18 (0.14, 0.22)

0.19 (0.14, 0.23)

0.13 (0.09, 0.17)

0.15 (0.11, 0.20)

0.15 (0.12, 0.18)

0.18 (0.14, 0.21)

0.14

0.01

1.16 (1.10, 1.22)

1.20 (1.14, 1.26)

1.23 (1.18, 1.29)

1.25 (1.20, 1.31)

1.25 (1.21, 1.29)

1.15 (1.11, 1.20)

1.19 (1.13, 1.26)

1.26 (1.17, 1.35)

1.16 (1.07, 1.25)

1.20 (1.13, 1.27)

1.19 (1.14, 1.24)

1.21 (1.15, 1.27)

0.21

0.01

1.21 (1.14, 1.28)

1.23 (1.16, 1.30)

1.27 (1.22, 1.33)

1.30 (1.23, 1.36)

1.29 (1.24, 1.33)

1.20 (1.14, 1.25)

1.25 (1.18, 1.33)

1.32 (1.22, 1.43)

1.22 (1.13, 1.33)

1.27 (1.19, 1.35)

1.25 (1.20, 1.31)

1.27 (1.21, 1.34)