Table 4 Multivariable-adjusted mean changes in cardiovascular disease risk factors (95% CI) over 6 years of follow-up among individuals without CVD or diabetes (includes normoglycemic adults and adults with prediabetes), according to quartiles of sedentary time and meeting guidelines for moderate-to-vigorous physical activity (N ~ 6114)

0.90 (0.68, 1.13)

1.06 (0.84, 1.28)

0.83 (0.61, 1.06)

0.93 (0.74, 1.12)

0.86

0.89 (0.75, 1.03)

0.98 (0.81, 1.16)

0.35

0.88 (0.65, 1.11)

1.04 (0.82, 1.26)

0.84 (0.62, 1.06)

0.93 (0.74, 1.13)

0.96

0.85 (0.71, 0.99)

1.01 (0.83, 1.18)

0.14

0.83 (0.58, 1.07)

1.04 (0.82, 1.26)

0.85 (0.64, 1.07)

0.98 (0.78, 1.18)

0.56

0.83 (0.68, 0.98)

1.03 (0.86, 1.20)

0.09

2.55 (1.97, 3.14)

2.70 (2.01, 3.38)

2.46 (1.75, 3.18)

3.23 (2.65, 3.81)

0.22

2.49 (2.05, 2.93)

3.02 (2.55, 3.49)

0.08

2.69 (2.06, 3.31)

2.76 (2.08, 3.44)

2.53 (1.86, 3.20)

2.86 (2.27, 3.45)

0.84

2.66 (2.21, 3.11)

2.77 (2.31, 3.24)

0.70

2.64 (1.96, 3.31)

2.76 (2.08, 3.44)

2.54 (1.87, 3.22)

2.90 (2.29, 3.51)

0.72

2.62 (2.15, 3.08)

2.81 (2.34, 3.29)

0.55

0.69 (−0.15, 1.52)

0.97 (0.04, 1.90)

0.46 (− 0.44, 1.36)

0.56 (− 0.28, 1.41)

0.69

0.70 (0.06, 1.35)

0.63 (− 0.09, 1.34)

0.88

0.70 (−0.20, 1.61)

0.99 (0.09, 1.88)

0.62 (− 0.28, 1.52)

0.42 (− 0.44, 1.28)

0.61

0.77 (0.10, 1.43)

0.58 (− 0.14, 1.30)

0.71

0.87 (−0.10, 1.83)

0.99 (0.10, 1.89)

0.58 (−0.33, 1.48)

0.30 (− 0.56, 1.17)

0.36

0.78 (0.09, 1.47)

0.56 (− 0.20, 1.32)

0.69

0.14 (−0.57, 0.85)

0.58 (−0.08, 1.25)

0.19 (− 0.54, 0.92)

0.83 (0.11, 1.54)

0.27

0.24 (− 0.28, 0.76)

0.66 (0.10, 1.21)

0.27

0.30 (−0.44, 1.04)

0.70 (0.04, 1.37)

0.26 (−0.45, 0.97)

0.42 (− 0.27, 1.11)

0.96

0.43 (− 0.10, 0.95)

0.41 (− 0.16, 0.98)

0.97

0.44 (−0.37, 1.24)

0.72 (0.05, 1.38)

0.21 (− 0.50, 0.93)

0.32 (− 0.38, 1.02)

0.67

0.44 (− 0.12, 0.99)

0.40 (− 0.21, 1.01)

0.93

−4.13 (−5.90, −2.35)

−2.58 (−5.00, − 0.17)

−3.45 (− 5.53, −1.37)

−3.24 (− 5.18, −1.31)

0.61

−2.95 (− 4.38, − 1.52)

−3.80 (− 5.35, − 2.24)

0.40

−4.52 (−6.40, − 2.65)

− 2.64 (− 5.04, − 0.23)

− 3.07 (− 5.11, − 1.03)

−3.32 (− 5.10, − 1.55)

0.41

− 2.66 (− 4.08, − 1.25)

− 4.19 (− 5.75, − 2.63)

0.13

−4.71 (− 6.73, − 2.69)

−2.68 (− 5.10, − 0.25)

−2.96 (− 5.02, − 0.90)

− 3.21 (− 5.04, − 1.38)

0.35

−2.96 (− 4.44, − 1.48)

−3.87 (− 5.50, − 2.24)

0.41

1.22 (0.46, 1.98)

1.19 (0.48, 1.89)

2.11 (1.23, 3.00)

1.60 (0.91, 2.29)

0.26

1.68 (1.17, 2.19)

1.37 (0.82, 1.93)

0.43

1.66 (0.85, 2.48)

1.22 (0.57, 1.88)

1.94 (1.10, 2.77)

1.28 (0.56, 1.99)

0.75

1.74 (1.21, 2.26)

1.29 (0.73, 1.85)

0.27

1.86 (0.95, 2.77)

1.23 (0.57, 1.88)

1.91 (1.06, 2.76)

1.11 (0.36, 1.86)

0.43

1.71 (1.15, 2.27)

1.32 (0.71, 1.93)

0.39

0.97 (0.93, 1.01)

0.95 (0.91, 0.99)

0.95 (0.91, 0.98)

0.97 (0.94, 1.00)

0.88

0.96 (0.93, 0.98)

0.96 (0.93, 0.99)

0.93

0.95 (0.91, 0.99)

0.95 (0.91, 0.99)

0.95 (0.92, 0.99)

0.97 (0.94, 1.00)

0.51

0.95 (0.93, 0.98)

0.96 (0.93, 0.99)

0.62

0.94 (0.90, 0.99)

0.95 (0.91, 0.98)

0.96 (0.92, 0.99)

0.98 (0.95, 1.01)

0.27

0.95 (0.93, 0.98)

0.96 (0.93, 0.99)

0.59

3.46 (2.73, 4.19)

4.45 (3.52, 5.39)

3.53 (2.78, 4.27)

3.87 (3.11, 4.63)

0.71

4.60 (4.04, 5.17)

2.96 (2.36, 3.56)

< 0.0001

2.92 (2.15, 3.69)

4.37 (3.45, 5.29)

3.69 (2.94, 4.44)

4.25 (3.48, 5.02)

0.04

4.23 (3.67, 4.80)

3.34 (2.75, 3.93)

0.01

2.92 (2.10, 3.74)

4.38 (3.46, 5.31)

3.63 (2.88, 4.39)

4.29 (3.49, 5.10)

0.07

4.32 (3.73, 4.91)

3.25 (2.61, 3.89)

0.01

7.75 (5.17, 10.32)

9.70 (6.93, 12.48)

8.11 (4.88, 11.34)

9.48 (7.14, 11.82)

0.44

8.55 (6.74, 10.36)

8.99 (6.88, 11.10)

0.73

6.92 (4.37, 9.47)

9.93 (7.08, 12.78)

8.48 (5.34, 11.61)

9.75 (7.40, 12.11)

0.14

8.78 (7.00, 10.55)

8.77 (6.70, 10.84)

0.99

7.36 (4.73, 9.98)

10.04 (7.19, 12.89)

8.25 (5.07, 11.43)

9.45 (6.90, 12.00)

0.39

8.63 (6.78, 10.48)

8.93 (6.81, 11.05)

0.82

0.15 (0.13, 0.18)

0.18 (0.16, 0.21)

0.15 (0.13, 0.17)

0.17 (0.15, 0.19)

0.63

0.16 (0.14, 0.17)

0.17 (0.15, 0.19)

0.25

0.15 (0.13, 0.17)

0.18 (0.16, 0.21)

0.16 (0.14, 0.18)

0.17 (0.15, 0.19)

0.21

0.16 (0.14, 0.17)

0.17 (0.15, 0.19)

0.18

0.14 (0.12, 0.16)

0.18 (0.16, 0.21)

0.16 (0.14, 0.18)

0.17 (0.15, 0.20)

0.11

0.16 (0.14, 0.17)

0.17 (0.15, 0.19)

0.33

1.23 (1.17, 1.29)

1.28 (1.21, 1.35)

1.23 (1.17, 1.29)

1.24 (1.18, 1.29)

0.99

1.27 (1.23, 1.31)

1.21 (1.17, 1.26)

0.03

1.19 (1.14, 1.25)

1.26 (1.20, 1.33)

1.24 (1.18, 1.30)

1.27 (1.22, 1.33)

0.05

1.26 (1.22, 1.30)

1.22 (1.18, 1.27)

0.16

1.20 (1.14, 1.27)

1.27 (1.20, 1.34)

1.23 (1.18, 1.30)

1.26 (1.21, 1.31)

0.28

1.26 (1.22, 1.31)

1.22 (1.17, 1.27)

0.10

1.28 (1.22, 1.35)

1.33 (1.25, 1.41)

1.27 (1.21, 1.34)

1.29 (1.23, 1.35)

0.85

1.33 (1.28, 1.37)

1.25 (1.20, 1.31)

0.01

1.23 (1.17, 1.30)

1.31 (1.24, 1.39)

1.29 (1.22, 1.36)

1.33 (1.27, 1.39)

0.04

1.31 (1.27, 1.36)

1.27 (1.22, 1.32)

0.11

1.25 (1.18, 1.32)

1.32 (1.24, 1.40)

1.28 (1.22, 1.35)

1.32 (1.26, 1.38)

0.21

1.32 (1.27, 1.37)

1.26 (1.21, 1.32)

0.06