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Table 1 Univariate analysis for risk factors for non-successful outcomes in 1416 pulmonary non-MDR TB cases

From: Risk factors affecting treatment outcomes for pulmonary tuberculosis in Finland 2007–2014: a national cohort study

Variable Category Successful
(n = 1063)
Died
(n = 231)
Univariate RRRa for deathb
(95%CI)
p
Unsatisfactoryc
(n = 50)
Univariate RRRa for unsatisfactoryb (95%CI)
p
Non-defined
(n = 72)
Univariate RRRa for non-definedb
(95%CI)
p
Age Age/10 years Median 57 years Median 79 years 1.77
(1.53–2.06)
< 0.001
Median 27.5 years 0.65
(0.59–0.72)
< 0.001
Median 51.5 years 0.96
(0.87–1.05)
0.341
Gender Female (n = 501) n = 387 (77.2%) n = 68 (13.6%) 1 n = 17
(3.4%)
1 n = 29
(5.8%)
1
  Male (n = 915) n = 676 (73.9%) n = 163 (17.8%) 1.37
(1.06–1.77)
0.015
n = 33
(3.6%)
1.11
(0.68–1.82)
0.677
n = 43
(4.7%)
0.85
(0.49–1.46)
0.552
Origin Finnish (n = 1030) n = 744 (72.2%) n = 225 (21.8%) 1 n = 13
(1.3%)
1 n = 48
(4.7%)
1
  Foreign (n = 386) n = 319 (82.6%) n = 6 (1.6%) 0.06
(0.04–0.11)
< 0.001
n = 37
(9.6%)
6.64
(3.68–11.98)
< 0.001
n = 24
(6.2%)
1.17
(0.70–1.93)
0.551
Drug resistance non-MDRd No (n = 1262) n = 966 (76.5%) n = 207
(16.4%)
1 n = 38
(3.0%)
1 n = 51
(4.0%)
1
  Yes (n = 118) n = 74
(62.7%)
n = 12
(10.2%)
0.76
(0.33–1.74)
0.511
n = 12
(10.2%)
4.12
(2.02–8.41)
< 0.001
n = 20
(16.9%)
5.12
(3.23–8.11)
< 0.001
Sputum smeare Negative (n = 629) n = 481 (76.5%) n = 96
(15.3%)
1 n = 23
(3.7%)
1 n = 29
(4.6%)
1
  Positive (n = 694) n = 527 (75.9%) n = 105
(15.1%)
0.998
(0.82–1.21)
0.986
n = 24
(3.5%)
0.95
(0.48–1.87)
0.888
n = 38
(5.5%)
1.20
(0.80–1.79)
0.387
Study period 2007–2010 (n = 760) n = 570 (75.0%) n = 118
(15.5%)
1 n = 31
(4.1%)
1 n = 41
(5.4%)
1
  2011–2014 (n = 656) n = 493 (75.2%) n = 113
(17.2%)
1.11
(0.88–1.39)
0.383
n = 19
(2.9%)
0.71
(0.51–0.99)
0.045
n = 31
(4.7%)
0.87
(0.43–1.77)
0.709
Charlsonf 0 (n = 631) n = 550 (87.2%) n = 30
(4.8%)
1 n = 17
(2.7%)
1 n = 34
(5.4%)
1
  1–2 (n = 462) n = 322 (69.7%) n = 111
(24.0%)
6.32
(4.57–8.74)
< 0.001
n = 9
(2.0%)
0.90
(0.30–3.73)
0.859
n = 20
(4.3%)
1.00
(0.60–1.67)
0.985
  3–4 (n = 172) n = 109 (63.4%) n = 54 (31.4%) 9.08
(5.63–14.66)
< 0.001
n = 1 (0.6%) 0.30
(0.04–2.36)
0.251
n = 8
(4.7%)
1.19
(0.50–2.82)
0.697
  ≥5 (n = 85) n = 52 (61.2%) n = 28 (32.9%) 9.87
(4.63–21.06)
< 0.001
n = 1 (1.2%) 0.62
(0.11–3.67)
0.600
n = 4
(4.7%)
1.24
(0.55–2.79)
0.596
  1. aratio of relative risks
  2. bcompared to successfully treated cases
  3. c including cases transferred out
  4. dInformation missing for 36 cases (23 successfully treated cases, 12 fatal cases, 1 non-defined case)
  5. eInformation missing for 93 cases (55 successfully treated cases, 30 fatal cases, 3 other defined unsuccessfully treated cases, 5 non-defined outcome)
  6. fInformation missing for 66 cases (30 successfully treated cases, 8 fatal cases, 22 other defined unsuccessfully treated cases, 6 non-defined outcome)