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Table 1 Univariate analysis for risk factors for non-successful outcomes in 1416 pulmonary non-MDR TB cases

From: Risk factors affecting treatment outcomes for pulmonary tuberculosis in Finland 2007–2014: a national cohort study

Variable

Category

Successful

(n = 1063)

Died

(n = 231)

Univariate RRRa for deathb

(95%CI)

p

Unsatisfactoryc

(n = 50)

Univariate RRRa for unsatisfactoryb (95%CI)

p

Non-defined

(n = 72)

Univariate RRRa for non-definedb

(95%CI)

p

Age

Age/10 years

Median 57 years

Median 79 years

1.77

(1.53–2.06)

< 0.001

Median 27.5 years

0.65

(0.59–0.72)

< 0.001

Median 51.5 years

0.96

(0.87–1.05)

0.341

Gender

Female (n = 501)

n = 387 (77.2%)

n = 68 (13.6%)

1

n = 17

(3.4%)

1

n = 29

(5.8%)

1

 

Male (n = 915)

n = 676 (73.9%)

n = 163 (17.8%)

1.37

(1.06–1.77)

0.015

n = 33

(3.6%)

1.11

(0.68–1.82)

0.677

n = 43

(4.7%)

0.85

(0.49–1.46)

0.552

Origin

Finnish (n = 1030)

n = 744 (72.2%)

n = 225 (21.8%)

1

n = 13

(1.3%)

1

n = 48

(4.7%)

1

 

Foreign (n = 386)

n = 319 (82.6%)

n = 6 (1.6%)

0.06

(0.04–0.11)

< 0.001

n = 37

(9.6%)

6.64

(3.68–11.98)

< 0.001

n = 24

(6.2%)

1.17

(0.70–1.93)

0.551

Drug resistance non-MDRd

No (n = 1262)

n = 966 (76.5%)

n = 207

(16.4%)

1

n = 38

(3.0%)

1

n = 51

(4.0%)

1

 

Yes (n = 118)

n = 74

(62.7%)

n = 12

(10.2%)

0.76

(0.33–1.74)

0.511

n = 12

(10.2%)

4.12

(2.02–8.41)

< 0.001

n = 20

(16.9%)

5.12

(3.23–8.11)

< 0.001

Sputum smeare

Negative (n = 629)

n = 481 (76.5%)

n = 96

(15.3%)

1

n = 23

(3.7%)

1

n = 29

(4.6%)

1

 

Positive (n = 694)

n = 527 (75.9%)

n = 105

(15.1%)

0.998

(0.82–1.21)

0.986

n = 24

(3.5%)

0.95

(0.48–1.87)

0.888

n = 38

(5.5%)

1.20

(0.80–1.79)

0.387

Study period

2007–2010 (n = 760)

n = 570 (75.0%)

n = 118

(15.5%)

1

n = 31

(4.1%)

1

n = 41

(5.4%)

1

 

2011–2014 (n = 656)

n = 493 (75.2%)

n = 113

(17.2%)

1.11

(0.88–1.39)

0.383

n = 19

(2.9%)

0.71

(0.51–0.99)

0.045

n = 31

(4.7%)

0.87

(0.43–1.77)

0.709

Charlsonf

0 (n = 631)

n = 550 (87.2%)

n = 30

(4.8%)

1

n = 17

(2.7%)

1

n = 34

(5.4%)

1

 

1–2 (n = 462)

n = 322 (69.7%)

n = 111

(24.0%)

6.32

(4.57–8.74)

< 0.001

n = 9

(2.0%)

0.90

(0.30–3.73)

0.859

n = 20

(4.3%)

1.00

(0.60–1.67)

0.985

 

3–4 (n = 172)

n = 109 (63.4%)

n = 54 (31.4%)

9.08

(5.63–14.66)

< 0.001

n = 1 (0.6%)

0.30

(0.04–2.36)

0.251

n = 8

(4.7%)

1.19

(0.50–2.82)

0.697

 

≥5 (n = 85)

n = 52 (61.2%)

n = 28 (32.9%)

9.87

(4.63–21.06)

< 0.001

n = 1 (1.2%)

0.62

(0.11–3.67)

0.600

n = 4

(4.7%)

1.24

(0.55–2.79)

0.596

  1. aratio of relative risks
  2. bcompared to successfully treated cases
  3. c including cases transferred out
  4. dInformation missing for 36 cases (23 successfully treated cases, 12 fatal cases, 1 non-defined case)
  5. eInformation missing for 93 cases (55 successfully treated cases, 30 fatal cases, 3 other defined unsuccessfully treated cases, 5 non-defined outcome)
  6. fInformation missing for 66 cases (30 successfully treated cases, 8 fatal cases, 22 other defined unsuccessfully treated cases, 6 non-defined outcome)
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BMC Public Health

ISSN: 1471-2458

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