Table 4 Interactions between Gene polymorphism and hypertension for the risk of type 2 diabetes mellitus

 Non-risk allele carriers (CC + CT)

9/503

29/549

1

2.95(1.38 ~ 6.30)

2.95(1.38 ~ 6.30)

P = 0.005

P = 0.005

 Risk allele carriers (TT)

11/482

44/536

1.35 (−0.60 ~ 3.32)

0.175

1.28(0.52 ~ 3.11)

4.59 (2.22 ~ 9.49)

3.60 (1.84 ~ 7.04)

P = 0.592

P < 0.001

P < 0.001

 OR(95%CI) for risk allele carriers within strata of hypertension

1.28(0.52 ~ 3.11)

1.25 (0.98 ~ 1.59)

P = 0.592

P = 0.074

 Non-risk allele carriers (TT)

1/305

17/337

1

15.39 (2.04 ~ 116.30)

15.39 (2.04 ~ 116.30)

P = 0.008

P = 0.008

 Risk allele carriers (AT+AA)

19/680

56/748

−0.08 (−10.78 ~ 10.63)

0.989

8.52 (1.14 ~ 63.95)

22.83 (3.15 ~ 165.69)

2.68 (1.58 ~ 4.56)

P = 0.037

P = 0.002

P < 0.001

 OR(95%CI) for risk allele carriers within strata of hypertension

8.52 (1.14 ~ 63.95)

1.48 (0.85 ~ 2.59)

P = 0.037

P = 0.165

 Non-risk allele carriers (CC + CT)

1/122

3/151

1

2.42 (0.25 ~ 23.60)

2.42 (0.25 ~ 23.60)

P = 0.446

P = 0.446

 Risk allele carriers (TT)

19/863

70/934

5.11 (−3.79 ~ 14.00)

0.260

2.69 (0.36 ~ 20.24)

9.14 (1.26 ~ 66.42)

3.40 (2.03 ~ 5.70)

P = 0.338

P = 0.029

P < 0.001

 OR(95%CI) for risk allele carriers within strata of hypertension

2.69 (0.36 ~ 20.24)

P = 0.338

1.94 (1.08 ~ 3.48)

P = 0.026

 Non-risk allele carriers (TT + CT)

8/571

32/605

1

3.78 (1.73 ~ 8.26)

3.78 (1.73 ~ 8.26)

P = 0.001

P = 0.001

 Risk allele carriers (CC)

12/414

41/480

1.26 (−1.40 ~ 3.91)

0.353

2.07 (0.84 ~ 5.11)

6.10 (2.83 ~ 13.13)

2.95 (1.53 ~ 5.68)

P = 0.115

P < 0.001

P = 0.001

 OR(95%CI) for risk allele carriers within strata of hypertension

2.07 (0.84 ~ 5.11)

P = 0.115

1.27 (1.00 ~ 1.61)

P = 0.049

 Non-risk allele carriers (CC)

10/615

41/690

1

3.65 (1.82 ~ 7.36)

3.65 (1.82 ~ 7.36)

P < 0.001

P < 0.001

 Risk allele carriers (GG + CG)

10/370

32/395

0.67 (−1.72 ~ 3.05)

0.584

1.66 (0.69 ~ 4.03)

4.98 (2.42 ~ 10.25)

3.00 (1.45 ~ 6.18)

P = 0.261

P < 0.001

P = 0.003

 OR(95%CI) for risk allele carriers within strata of hypertension

1.66 (0.69 ~ 4.03)

P = 0.261

1.17 (0.92 ~ 1.48)

P = 0.204