Table 3 Predictors of suppressed viral load (< 50 copies/mL) at 12-month post-down-referral/ eligibility
Suppressed VL (1535/2881) | RR | aRR | |
|---|---|---|---|
n (%) | (95% CI) | (95% CI) | |
Study cohort | |||
GP down-referred | 228 (65.7) | 1 | 1 |
Clinic A controls | 934 (49.1) | 0.7 (0.7–0.8) | 1.0 (0.9–1.1) |
Clinic B controls | 373 (58.9) | 0.9 (0.8–0.99) | 1.0 (0.9–1.2) |
Sex | |||
Female | 1036 (53.7) | 1 | 1 |
Male | 499 (52.5) | 1.0 (0.9–1.1) | 1.0 (0.9–1.0) |
Age at down-referral/eligibility (years) Median (IQR) | |||
18–29.99 | 193 (55.3) | 1 | 1 |
30–39.99 | 657 (55.8) | 1.0 (0.9–1.1) | 1.0 (0.9–1.1) |
40–49.99 | 481 (51.4) | 0.9 (0.8–1.0) | 0.9 (0.9–1.0) |
50+ | 204 (48.8) | 0.9 (0.8–1.0) | 1.0 (0.9–1.1) |
Nationality | |||
South African | 1363 (53.2) | 1 | |
Non-South African | 172 (53.9) | 1.0 (0.9–1.1) | |
Education level | |||
Primary school or less | 275 (51.7) | 1.0 (0.9–1.0) | |
Some secondary school | 350 (53.9) | 1.0 (0.9–1.1) | |
> =Grade 12 | 765 (54.2) | 1 | |
Employment status | |||
Employed | 768 (53.6) | 1 | |
Unemployed | 731 (52.9) | 1.0 (0.9–1.1) | |
Time on ART at down-referral/eligibility (years) Median (IQR) | |||
1–2 year | 860 (54.6) | 1 | 1 |
3–4 years | 350 (51.8) | 0.9 (0.9–1.0) | 1.0 (0.9–1.1) |
> =5 years | 325 (51.7) | 0.9 (0.9–1.0) | 0.9 (0.9–1.0) |
Guideline year of ART initiation | |||
2004–2010 | 929 (52.2) | 1 | |
2010–2014 | 606 (54.9) | 1.1 (0.98–1.1) | |
Baseline CD4 (cells/μl) | |||
250–349.9 | 472 (54.5) | 1.0 (0.96–1.0) | |
350–499.9 | 510 (53.6) | 1.0 (0.9–1.1) | |
> =500 | 553 (52.0) | ||
Baseline Haemoglobin (g/dL) | – | 1.0 (0.97–1.0) | |
Baseline VL (copies/mL) | |||
< 50 | 1431 (81.4) | 1 | 1 |
50–149 | 61 (10.9) | 0.1 (0.1–0.2) | 0.1 (0.1–0.2) |
150–299 | 33 (8.1) | 0.1 (0.1–0.1) | 0.1 (0.1–0.1) |
300–399 | 10 (6.5) | 0.1 (0.04–0.1) | 0.1 (0.04–0.1) |
Baseline BMI (kg/m2) | |||
Normal | 715 (54.1) | 1 | |
Overweight | 382 (52.4) | 1.0 (0.9–1.1) | |
Obese | 222 (52.6) | 1.0 (0.9–1.1) | |
ART regimen | |||
TDF + 3TC/FTC + EFV/NVP | 595 (55.7) | 1 | 1 |
AZT + 3TC + EFV/NVP | 100 (60.2) | 1.1 (0.9–1.2) | 1.0 (0.9–1.1) |
d4T + 3TC + EFV/NVP | 825 (51.0) | 0.9 (0.9–0.98) | 1.0 (0.9–1.0) |
12 month Retention | |||
Alive and in care | 1121 (55.5) | 1 | 1 |
LTFU | 117 (47.0) | 0.9 (0.8–0.99) | 0.8 (0.7–0.9) |
Deceased | 16 (55.2) | 1.0 (0.7–1.4) | 1.0 (0.8–1.2) |
Transferred out | 281 (51.6) | 0.9 (0.9–1.0) | 0.9 (0.9–1.0) |