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Table 1 Characteristics of persons with latent tuberculosis infection who initiated INH monotherapy and followed for twelve months

From: Timing of treatment interruption among latently infected tuberculosis cases treated with a nine-month course of daily isoniazid: findings from a time to event analysis

Predictors (N = 12,495)

Sample

N (%)

Treatment Completed

N (%)

Loss to Follow

N (%)

Chose to Stop

N (%)

Adverse Reaction

N (%)

Died

N (%)

p-value

  

6201 (49.6)

3120 (25.0)

2928 (23.4)

237 (1.9)

9 (0.1)

 

Type of Patients

Pediatric

Recent Contact

Other Adults

3150 (25.2)

1619 (13.0)

7726 (61.8)

1639 (52.0)

901 (55.6)

3661 (47.4)

823 (26.1)

382 (23.6)

1915 (24.8)

635 (20.2)

310 (19.1)

1983 (25.7)

53 (1.7)

25 (1.5)

159 (2.1)

-

1 (0.1)

8 (0.1)

<.0001

Gender

Female

Male

Missing

6076 (48.6)

6417 (51.4)

2 (0.0)

3090 (50.9)

3111 (48.5)

-

1433 (23.6)

1685 (26.3)

2 (100.0)

1400 (23.0)

1528 (23.8)

-

150 (2.5)

87 (1.4)

3 (0.0)

6 (0.1)

<.0001

Ethnicity

Non-Hispanic

Hispanic

Unknown

6808 (54.5)

5513 (44.1)

174 (1.4)

3714 (54.5)

2394 (43.4)

93 (53.4)

1881 (27.6)

1189 (21.6)

50 (28.7)

1093 (16.0)

1807 (32.8)

28 (16.1)

114 (1.7)

120 (2.2)

3 (1.7)

6 (0.1)

3 (0.0)

-

<.0001

Race

White

Black

Asian

Other

4496 (36.0)

4261 (34.1)

932 (7.5)

2806 (22.5)

2027 (45.1)

2035 (47.8)

650 (69.7)

1489 (53.1)

1004 (45.1)

1328 (47.8)

194 (20.8)

594 (21.2)

1350 (30.0)

833 (19.5)

80 (8.6)

665 (23.7)

110 (2.4)

63 (1.5)

7 (0.7)

57 (2.0)

5 (0.1)

2 (0.0)

1 (0.1)

1 (0.0)

<.0001

Birth Origin

U.S.-born

Non-U.S.-born, ≤ 5 Years

Non-U.S.-born, >  5 Years

5097 (40.8)

6517 (52.2)

881 (7.0)

2780 (54.5)

2998 (46.0)

423 (48.0)

1325 (26.0)

1591 (24.4)

204 (23.2)

890 (17.5)

1802 (27.6)

236 (26.8)

96 (1.9)

124 (1.9)

17 (1.9)

6 (0.1)

2 (0.0)

1 (0.1)

<.0001

HIV Co-infected

No

Yes

12,275 (98.2)

220 (1.8)

6038 (49.2)

163 (74.1)

3087 (25.1)

33 (15.0)

2907 (23.7)

21 (9.5)

236 (1.9)

1 (0.4)

7 (0.1)

2 (0.9)

<.0001

Diabetic

       

No

Yes

12,512 (98.2)

170 (1.3)

6099 (49.5)

102 (60.4)

3079 (25.0)

41 (24.3)

2906 (23.6)

22 (13.0)

234 (1.9)

3 (1.8)

8 (0.1)

1 (0.6)

0.0010

Other Immunosuppressive Conditions*

No

Yes

12,395 (99.2)

100 (0.8)

6136 (49.5)

65 (65.0)

3104 (25.0)

16 (16.0)

2913 (23.5)

15 (15.0)

235 (1.9)

2 (2.0)

7 (0.1)

2 (2.0)

<.0001

  1. Notes: * includes individuals with hematologic disorders (n = 6), chronic renal failure (n = 21), non-HIV related immunosuppressive conditions (n = 48), and those on corticosteroid therapy (n = 21)
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