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Table 1 Characteristics of the included studies

From: Prevalence and laboratory analysis of malaria and dengue co-infection: a systematic review and meta-analysis

Reference Study area
(years of the survey)
Age range Plasmodium sp. The magnitude of outcome in those co-infected compared to those with only malaria Case enrolled Case of co-infection Case of malaria alone Case of dengue alone Diagnostic Techniques
Assir et al., 2014 [16] Pakistan (2012) 12–90 P.falciparum and P.vivax 1. Co-infection rate = 1.99%
2. Hemoglobin = similar
3. Hematocrit = similar
4. Platelet count = similar
52 17 18 5 Malaria: Microscopy
Dengue: ELISA NS1,IgM, RT-PCR
Baba et al., 2013 [18] Nigeria (2008) < 1- > 80 y P. falciparum 1. Co-infection rate 7.17% 310 18 31 175 Malaria: Microscopy
Dengue: Plaque reduction neutralization test (PRNT)
Barua and Gill, 2016 [19] India (2014) > 12 y P.falciparum and P.vivax 1. Co-infection rate 10.25%
2. Hemoglobin = higher
3. Hematocrit = similar
4. Platelet count = lower
5. AST = higher
6. ALT = higher
156 16 55 85 Malaria: Microscopy
Dengue: IgM, NS1
Carme et al., 2009 [20] French Guiana (2004–2005) NA P.falciparum and P.vivax 1. Co-infection rate 1% 1723 17 376 221 Malaria: Microscopy
Dengue: IgM serology, culture, RT-PCR
Chipwaza et al., 2014 [21] Tanzania (2013) 2–13 NA 1. Co-infection rate 8.5% 364 31 52 45 Malaria: Microscopy
Dengue: ELISA
Epelboin et al., 2012 [22] French Guiana (2004–2010) 6 m-83 y P.falciparum and P.vivax 1. Parasitemia = similar
2. Hemoglobin = similar
3. Hematocrit = lower
4. Platelet count = lower
5. AST = similar
6. ALT = similar
Not given 104 208 104 Malaria: Microscopy
Dengue: Cell-culture virus isolation, RT-PCR, NS1, IgM, IgM, IgM + IgA
Hati et al., 2012 [23] India (2005–2010) NA P.falciparum and P.vivax 1. Co-infection rate 1.5% 2971 46 194 559 Malaria: Microscopy
Dengue: ELISA
Magalhaes et al., 2014 [14] Brazil (2009–2011) 0- > 60 y P.falciparum and P.vivax 1. Co-infection rate = 3.16%
2. Parasitemia = similar
3. Hematocrit = higher
4. Platelet count = lower
5. AST = higher
6. ALT = higher
1578 44 176 584 Malaria: PCR.
Dengue: IgM, NS1, RT-PCR
Mendonça et al., 2015 [15] Brazil (2009–2013) IQR20.8–52.25 y P. vivax 1. Parasitemia = similar
2. Hemoglobin = similar
3. Hematocrit = similar
4. Platelet count = similar
5. AST = lower
6. ALT = higher
Not given 30 52 30 Malaria: Microscopy, PCR
Dengue: RT-PCR
Mohapatra et al., 2012 [24] India (2011) NA P.falciparum and P.vivax 1. Co-infection rate = 6%
2. Parasitemia = lower
3. Hemoglobin = higher
4. Platelet count = lower
5. AST = lower
6. ALT = lower
469 27 102 340 Malaria: Microscopy
Dengue: RDT (NS1, IgM)
Mueller et al., 2014 [25] Cambodia (2008–2010) 7–49 y P.falciparum and P.vivax 1. Co-infection rate = 3.24% 1475 27 727 53 Malaria: RDT, Nested-PCR
Dengue: RT-PCR
Rao et al., 2016 [26] India (2013) < 1- > 15 y P.falciparum and P.vivax 1. Co-infection rate = 1% 1980 22 229 723 Malaria: Microscopy, RDT.
Dengue: Dengue NS1, ELISA, RT-PCR
Swoboda et al., 2014 [27] Bangladesh (2007–2010) ≥8 y P.falciparum and P.vivax 1. Co-infection rate = 0.76% 659 5 362 35 Malaria: Microscopy, RDT.
Dengue: ELISA IgM
Sow et al., 2016 [28] Senegal (2009–2013) >  1 y P. falciparum 1. Co-infection rate = 0.01% 13,845 1 7386 2 Malaria: Microscopy, RDT
Dengue: RT-PCR
Zaki and Shanbag, 2010 [29] India (2005) 1 m-12 y P.falciparum and P.vivax 1. Co-infection rate = 0.33% 602 2 33 79 Malaria: Microscopy
Dengue: ELISA