Table 3 Genotype and allele frequencies at polymorphic RAAS sites
Gene | Locus | Group | Genotype frequency | P value* | ||
|---|---|---|---|---|---|---|
AA | AT | TT | ||||
ACE | rs4425 | Normal | 81 (41.5) | 80 (41.3) | 34 (17.4) | < 0.01 |
Cases | 68 (42.0) | 38 (23.4) | 56 (34.6) | |||
GG | AG | AA | ||||
ACE | rs4429 | Normal | 78 (40.0) | 64 (32.8) | 53 (27.2) | 0.42 |
Cases | 76 (46.9) | 47 (29.0) | 39 (24.1) | |||
ACE | rs4337 | GG | CG | CC | ||
Normal | 81 (41.5) | 71 (36.4) | 43 (22.1) | 0.01 | ||
Cases | 49 (30.2) | 54 (33.3) | 59 (36.5) | |||
GG | AG | AA | ||||
ATR | rs129876 | Normal | 135 (69.2) | 28 (14.4) | 32 (16.4) | < 0.01 |
Cases | 69 (42.6) | 29 (17.9) | 64 (39.6) | |||
TT | CT | CC | ||||
AGT | rs3637 | Normal | 88 (45.1) | 39 (20.0) | 68 (34.9) | 0.28 |
Cases | 79 (48.7) | 22 (13.6) | 61 (37.7) | |||
CC | CT | TT | ||||
CYP11B2 | rs1912 | Normal | 67 (34.4) | 31 (15.9) | 97 (49.7) | < 0.01 |
Cases | 30 (18.5) | 32 (19.8) | 100 (61.7) | |||