|
Muscular
|
|
Generalized chronic pain
|
380 (84.4)
|
583 (91.7)
|
< 0.001***
|
|
Muscle weakness
|
439 (97.6)
|
619 (97.3)
|
0.815
|
|
Post-exertional malaise
|
441 (98.0)
|
630 (99.1)
|
0.142
|
|
Difficulty performing fine movements due to pain
|
389 (86.4)
|
553 (86.9)
|
0.809
|
|
Marked muscle contractures
|
396 (88.0)
|
567 (89.2)
|
0.555
|
|
Myoclonic
|
156 (34.7)
|
264 (41.6)
|
0.023*
|
|
Falls due to loss of tone
|
74 (16.4)
|
159 (25.0)
|
0.001***
|
|
Cognitive
|
|
Concentration impairments
|
424 (94.2)
|
616 (96.9)
|
0.034*
|
|
Alterations in short-term memory consolidation
|
410 (91.1)
|
610 (95.9)
|
0.001***
|
|
Alterations during task planning
|
355 (78.9)
|
577 (90.7)
|
< 0.001***
|
|
Difficulty with calculation
|
385 (85.6)
|
584 (91.8)
|
0.001***
|
|
Difficulty redding
|
402 (89.3)
|
594 (93.4)
|
0.017*
|
|
Confusion and forgetfulness
|
361 (80.2)
|
560 (88.1)
|
< 0.001***
|
|
Temporal-spatial disorientation
|
282 (62.7)
|
481 (75.6)
|
< 0.001***
|
|
Episodes of nominal aphasia
|
382 (84.9)
|
565 (88.8)
|
0.055
|
|
Auditory and visual agnosia
|
133 (29.6)
|
257 (40.4)
|
< 0.001***
|
|
Neurological
|
|
Ataxia and/or dissymmetry
|
331 (73.6)
|
514 (80.8)
|
0.005**
|
|
Sensory hypersensitivity
|
403 (89.6)
|
582 (91.5)
|
0.275
|
|
Visual alterations
|
290 (64.4)
|
472 (74.2)
|
0.001***
|
|
Motor incoordination, with or without falls
|
339 (75.3)
|
511 (80.3)
|
0.048*
|
|
Autonomic
|
|
Dizziness or cephalic instability
|
356 (79.1)
|
552 (86.8)
|
0.001***
|
|
Vertigo
|
322 (71.6)
|
496 (78.0)
|
< 0.001***
|
|
Orthostatic hypotension
|
342 (76.0)
|
512 (80.5)
|
0.009**
|
|
Lipothymia
|
80 (17.8)
|
171 (26.9)
|
0.017*
|
|
Syncope
|
48 (10.7)
|
98 (15.4)
|
0.015*
|
|
Frequent palpitations
|
313 (69.6)
|
495 (77.8)
|
0.074
|
|
Tremor
|
171 (38.0)
|
314 (49.4)
|
< 0.001***
|
|
Profuse sweating
|
285 (63.3)
|
451 (70.9)
|
0.024*
|
|
Altered bowel habits
|
296 (65.8)
|
467 (73.4)
|
0.002**
|
|
Alterations in urination
|
224 (49.8)
|
395 (62.1)
|
< 0.001***
|
|
Reduced libido/anorgasmia/impotence
|
314 (69.8)
|
489 (76.9)
|
0.008**
|
|
Difficulties in visual accommodation
|
321 (71.3)
|
494 (77.7)
|
0.007**
|
|
Inmunological
|
|
Recurrent low-fever
|
326 (72.4)
|
473 (74.4)
|
0.478
|
|
Recurrent odynophagia
|
306 (68.0)
|
477 (75.0)
|
0.060
|
|
Painful lymph nodes
|
236 (52.4)
|
389 (61.2)
|
0.061
|
|
Raynaud’s phenomenon
|
125 (27.8)
|
225 (35.4)
|
0.552
|
|
Generalized morning numbness
|
343 (76.2)
|
521 (81.9)
|
0.743
|
|
Migratory arthralgias
|
376 (83.6)
|
547 (86.0)
|
0.996
|
|
Allergy to multiple medications
|
95 (21.1)
|
168 (26.4)
|
0.011*
|
|
Food intolerance
|
41 (9.1)
|
78 (12.3)
|
0.004**
|
|
Allergy to multiple metals
|
51 (11.3)
|
110 (17.3)
|
0.008**
|
|
History of sinusitis
|
30 (6.7)
|
63 (9.9)
|
0.022*
|
|
Facial swelling
|
19 (4.2)
|
44 (6.9)
|
0.265
|
|
Mouth ulcers
|
238 (52.9)
|
348 (54.7)
|
0.044*
|
|
Herpes
|
226 (50.2)
|
313 (49.2)
|
0.101
|
|
Candidiasis
|
172 (38.2)
|
243 (38.2)
|
0.006**
|
