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Table 3 Missing data and exact agreement for variables included in the validation of the notification section of the Swedish National Register for Breast Cancer

From: Validation of data quality in the Swedish National Register for Breast Cancer

Variable in the Swedish National Register for Breast Cancer Missing values in the NBCR (%) Missing values in the medical records (%) Missing values in both sources (%) Exact agreement (%)
Diagnostics Menstrual status 62/799 (7.8) 90/799 (11.3) 28/799 (3.5) 82.6
Laterality 0/799 (0) 0/799 (0) 0/799 (0) 98.5
Initial contact (referral/mammography/self-admission) 14/799 (1.8) 7/799 (0.9%) 0/799 (0) 88.1
Malignant diagnosis confirmed at first visit 3/799 (0.4) 29/799 (3.6) 0/799 (0) 83.5
Screening detected 5 /799 (0.6) 3/799 (0.4) 0/799 (0) 94.9
Malignant diagnosis confirmed preoperatively 4/799 (0.5) 43/799 (5.4) 2/799 (0.3) 91.2
Base for diagnosis 0/799 (0) 0/799 (0) 0/799 (0) 77.9
Preoperative multidisciplinary conference 2/799 (0.3) 2/799 (0.3) 0/799 (0) 95.2
Stage T classification 1/799 (0.01) 0/799 (0) 0/799 (0) 70.1
N classification 0/799 (0) 0/799 (0) 0/799 (0) 93.0
M classification 0/799 (0) 0/799 (0) 0/799 (0) 98.6
Planned care Primary surgery planned 0/799 (0) 0/799 (0) 0/799 (0) 98.3
Reason for no primary surgery 1/96 (1.0) 5/96 (5.2) 1/96 (1.0) 53.1
Primary systemic treatment 5/799 (0.6) 2/799 (0.3) 0/799 (0) 95.6
Primary radiotherapy 0/69 (0) 0/69 (0) 0/69 (0) 100
Primary endocrine therapy 0/69 (0) 0/69 (0) 0/69 (0) 95.7
Primary chemotherapy 0/69 (0) 0/69 (0) 0/69 (0) 97.1
Other primary systemic or targeted treatment 0/69 (0) 0/69 (0) 0/69 (0) 87.0
Surgery Final result breast surgery 0/739 (0) 1/739 (0.1) 0/739 (0) 95.9
Immediate breast reconstruction 1/739 (0.1) 1/739 (0.1) 0/739 (0) 98.5
Contralateral surgery for symmetry 3/739 (0.4) 1/739 (0.1) 0/739 (0) 98.6
Contralateral prophylactic surgery 6/739 (0.9) 1/739 (0.1) 0/739 (0) 96.2
Sentinel node biopsy (SNB) 0/739 (0) 2/739 (0.3) 1/739 (0.1) 95.4
Axillary surgery 0/739 (0) 1/739 (0.1) 1/739 (0.1) 90.9
Final result axillary surgery 0/701 (0) 7/739 (0.9) 2/739 (0.3) 89.8
Reoperative breast surgery 1/739 (0.1) 1/739 (0.1) 0/739 (0) 98.51
Residual disease detected after reoperation 2/63 (3.2) 5/63 (7.9) 1/63 (1.6) 82.5
Reoperative axillary surgery 1/739 (0.1) 5/739 (0.7) 0/739 (0) 96.9
Reason for reoperative axillary surgery 0/33 (0) 9/33 (27) 0/33 (0) 57.6
Reoperative surgery due to complications 2/739 (0.3) 2/739 (0.3) 0/739 (0) 96.6
Histopathology Basis for histopathological diagnosis 3/799 (0.4) 8/799 (1.0) 1/799 (0.1) 97.7
Invasiveness 6/799 (0.8) 21/799 (2.6) 4/799 (0.5) 86.0
Type of invasive carcinoma 2/688 (0.3) 10/688 (1.5) 1/688 (0.1) 89.7
Type of in situ carcinoma 2/465 (0.4) 23/465 (4.9) 2/465 (0.4) 87.5
Number of invasive tumors 7/644 (1.1) 5/644 (0.8) 0/644 (0) 93.6
Multifocality 9/111 (8.1) 5/111 (4.5) 2/111 (1.8) 76.6
Number of sentinel nodes 1/604 (0.2) 2/604 (0.3) 0/604 (0) 91.0
Metastasis in SN 0/604 (0) 12/604 (2.0) 0/604 (0) 93.9
Number of SN with macrometastases 2/119 (1.7) 23/119 (19) 1/119 (0.8) 85.3
Number of SN with micrometastases 4/119 (3.4) 41/119 (34) 2/119 (1.7) 82.9
Number of SN with submicrometastases 2/119 (1.7) 53/119 (44.5) 1/119 (0.8) 89.2
Nottingham Histological Grade or Nuclear Grade 40/786 (5.1) 50/786 (6.4) 24/786 (3.1) 88.9
ER status 41/786 (5.2) 40/786 (5.1) 10/786 (1.3) 90.5
PR status 45/786 (5.7) 48/786 (6.1) 10/786 (1.3) 85.2
KI67 status 85/786 (10.8) 73/786 (9.3) 85/786 (1.8) 73.5
HER2 status 60/799 (7.5) 84/799 (10.5) 32/799 (4.0) 73.3
Presence of vascular invasion 161/786 (20.5) 175/786 (22.3) 99/786 (12.6) 79.8
Postoperative treatment Postoperative multidisciplinary conference 3/739 (0.4) 9/739 (1.2) 1/739 (0.1) 94.2
Planned postoperative adjuvant treatment 1/739 (0.1) 9/739 (1.2) 1/739 (0.1) 96.6
Postoperative radiotherapy 1/673 (0.1) 12/673 (1.8) 1/673 (0.1) 95.5
Radiotherapy to breast or chest wall 0/519 (0) 0/519 (0) 0/519 (0) 76.9
Locoregional radiotherapy 0/519 (0) 0/519 (0) 0/519 (0) 87.1
Endocrine treatment 2/673 (0.3) 14/673 (2.1) 1/673 (0.1) 93.8
Antiestrogen 0/532 (0) 0/532 (0) 0/532 (0) 81.6
Aromatase inhibitor 0/532 (0) 0/532 (0) 0/532 (0) 86.8
Postoperative chemotherapy 2/673 (0.3) 12/673 (1.8) 1/673 (0.1) 94.8
Anthracycline based 0/232 (0) 0/232 (0) 0/232 (0) 62.5
CMF 0/232 (0) 0/232 (0) 0/232 (0) 94.8
Taxanes 0/232 (0) 0/232 (0) 0/232 (0) 77.6
Other chemotherapy 0/232 (0) 0/232 (0) 0/232 (0) 87.9
Targeted therapy 4/673 (0.6) 14/673 (0.2) 1/673 (0.1) 95.5
Trastuzumab 0/59 (0) 0/59 (0) 0/59 (0) 71.2
Castration (medical) 6/670 (0.9) 20/673 (3.0) 9/673 (0.3) 96.3