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Table 3 Hazard ratios for outcomes according to the interaction terms for age group and RRF

From: Influence of age on the effect of reduced renal function on outcomes in patients with coronary artery disease

Outcomes

All-cause mortality

Cardiac mortality

Models

HR (95% CI)

HR (95% CI)

Model 1

 RRF*age (≤59)

1.00(reference)

1.00(reference)

 RRF*age (60–69)

0.46 (0.19–1.15)

0.50 (0.67–2.14)

 RRF*age (≥70)

0.27 (0.12–0.61)

0.33 (0.11–0.97)

 P for trend

0.003

0.048

Model 2

 RRF*age (≤59)

1.00(reference)

1.00(reference)

 RRF*age (60–69)

0.60 (0.23–1.54)

1.18 (0.34–4.16)

 RRF*age (≥70)

0.32 (0.14–0.75)

0.48 (0.15–1.55)

 P for trend

0.010

0.053

  1. Model 1 includes age group, RRF (eGFR < 60 ml/min/1.73 m2), and the interaction terms for them (RRF*age group)
  2. Model 2 includes age group, RRF (< 60 ml/min/1.73 m2), the interaction terms for them (RRF*age group), and further adjusted for gender, pre-hypertension, pre-diabetes mellitus, systolic blood pressure, Killip class, severity of CAD, diagnosis of ACS, treatment of PCI
  3. Abbreviations: RRF reduced renal function; eGFR estimated glomerular filtration rate, HR hazard ratio, CI confidence interval, CAD coronary artery disease, ACS acute coronary syndrome, PCI percutaneous coronary intervention