Fig. 3
Age distribution of cases, and evaluation of the optimum age for Dengue vaccination. An example of the applied procedure of estimation of optimal age and its confidence interval: a) the proportion of dengue cases by age a; b) H(a) as a function of age a; c) the derivative of H(a) with respect to age a. The data correspond to dengue cases in Maceio in 2014. The dotted line connecting the data is a linear interpolation, and the symbol (+) corresponds to simulated curves. The optimal age is 8.0 years, and the confidence interval is [6.7,9.3]