Table 6 Association between cardiovascular disease or risk factors and current NSAID consumption (odds ratios and 95% confidence intervals adjusted by age, BMI, educational level, smoking, province of recruitment and presence of arthritis, gout or chronic cephalalgia)
From: Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study
NSAID | Cardiovascular disease or risk factor | Women | Men |
|---|---|---|---|
Non-aspirin NSAID | Diabetes mellitus | 1.06 (0.70–1.62) | 0.59 (0.37–0.95) |
Hypertension | 1.02 (0.76–1.38) | 0.81 (0.57–1.31) | |
Hypercholesterolemia | 1.13 (0.86–1.47) | 1.05 (0.75–1.47) | |
Acute coronary syndrome | 0.64 (0.29–1.43) | 0.86 (0.51–1.44) | |
Stroke | 1.00 (0.58–1.13) | 1.11 (0.51–2.43) | |
Other circulatory diseases | 0.81 (0.58–1.13) | 0.99 (0.63–1.58) | |
Propionic derivates | Diabetes mellitus | 1.28 (0.79–2.06) | 0.56 (0.30–1.04) |
Hypertension | 0.94 (0.66–1.32) | 0.81 (0.54–1.23) | |
Hypercholesterolemia | 1.23 (0.90–1.66) | 1.06 (0.70–1.59) | |
Acute coronary syndrome | 1.07 (0.46–2.52) | 0.63 (0.31–1.30) | |
Stroke | 0.85 (0.32–2.22) | 0.45 (0.11–1.90) | |
Other circulatory diseases | 0.72 (0.49–1.08) | 0.71 (0.38–1.35) | |
Aspirin | Diabetes mellitus | 4.36 (2.39–7.94) | 2.44 (1.73–3.43) |
Hypertension | 4.98 (2.48–9.98) | 2.44 (1.73–3.43) | |
Hypercholesterolemia | 2.15 (1.22–3.79) | 3.62 (2.58–5.07) | |
Acute coronary syndrome | 15.2 (7.43–31.2) | 11.1 (7.81–15.9) | |
Stroke | 13.3 (6.24–28.3) | 2.09 (1.19–3.66) | |
Other circulatory diseases | 3.86 (2.16–6.90) | 3.56 (2.51–5.04) | |
Acetic acid derivates | Diabetes mellitus | 0.81 (0.33–1.99) | 0.95 (0.45–2.01) |
Hypertension | 1.39 (0.76–2.52) | 1.01 (0.54–1.89) | |
Hypercholesterolemia | 1.36 (0.78–2.35) | 0.84 (0.45–1.58) | |
Acute coronary syndrome | – | 0.69 (0.26–1.84) | |
Stroke | 1.77 (0.51–6.12) | 1.75 (0.58–5.31) | |
Other circulatory diseases | 1.53 (0.83–2.80) | 0.97 (0.43–2.19) |