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Table 6 Association between cardiovascular disease or risk factors and current NSAID consumption (odds ratios and 95% confidence intervals adjusted by age, BMI, educational level, smoking, province of recruitment and presence of arthritis, gout or chronic cephalalgia)

From: Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study

NSAID Cardiovascular disease or risk factor Women Men
Non-aspirin NSAID Diabetes mellitus 1.06 (0.70–1.62) 0.59 (0.37–0.95)
Hypertension 1.02 (0.76–1.38) 0.81 (0.57–1.31)
Hypercholesterolemia 1.13 (0.86–1.47) 1.05 (0.75–1.47)
Acute coronary syndrome 0.64 (0.29–1.43) 0.86 (0.51–1.44)
Stroke 1.00 (0.58–1.13) 1.11 (0.51–2.43)
Other circulatory diseases 0.81 (0.58–1.13) 0.99 (0.63–1.58)
Propionic derivates Diabetes mellitus 1.28 (0.79–2.06) 0.56 (0.30–1.04)
Hypertension 0.94 (0.66–1.32) 0.81 (0.54–1.23)
Hypercholesterolemia 1.23 (0.90–1.66) 1.06 (0.70–1.59)
Acute coronary syndrome 1.07 (0.46–2.52) 0.63 (0.31–1.30)
Stroke 0.85 (0.32–2.22) 0.45 (0.11–1.90)
Other circulatory diseases 0.72 (0.49–1.08) 0.71 (0.38–1.35)
Aspirin Diabetes mellitus 4.36 (2.39–7.94) 2.44 (1.73–3.43)
Hypertension 4.98 (2.48–9.98) 2.44 (1.73–3.43)
Hypercholesterolemia 2.15 (1.22–3.79) 3.62 (2.58–5.07)
Acute coronary syndrome 15.2 (7.43–31.2) 11.1 (7.81–15.9)
Stroke 13.3 (6.24–28.3) 2.09 (1.19–3.66)
Other circulatory diseases 3.86 (2.16–6.90) 3.56 (2.51–5.04)
Acetic acid derivates Diabetes mellitus 0.81 (0.33–1.99) 0.95 (0.45–2.01)
Hypertension 1.39 (0.76–2.52) 1.01 (0.54–1.89)
Hypercholesterolemia 1.36 (0.78–2.35) 0.84 (0.45–1.58)
Acute coronary syndrome 0.69 (0.26–1.84)
Stroke 1.77 (0.51–6.12) 1.75 (0.58–5.31)
Other circulatory diseases 1.53 (0.83–2.80) 0.97 (0.43–2.19)