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Table 2 Estimated cumulative transition hazard ratios along with 95% confidence bands at elected time points for a set of covariates given by age, gender, race/ethnicity, CCI and dual eligibility. For age and CCI, the odds ratio is defined as the ratio of odds for a unit increment of the variable. For gender, race/ethnicity and dual eligibility the ratio is calculated relative to males, whites, and ineligibility, respectively

From: Progression of diabetes, ischemic heart disease, and chronic kidney disease in a three chronic conditions multistate model

States

Days

Age

Gender (Females vs. Males)

Race/Ethnicity

CCI

Dual Eligibility

From

To

Asian vs. White

NHPI vs. white

Others vs. White

DM

DM + IHD

365

0.994 (0.990, 0.997)

0.863 (0.799, 0.932)

0.971 (0.875, 1.077)

1.009 (0.907, 1.122)

1.014 (0.908, 1.132)

0.940 (0.912, 0.968)

1.183 (1.061, 1.319)

730

0.996 (0.993, 0.999)

0.849 (0.793, 0.910)

1.010 (0.920, 1.108)

1.041 (0.947, 1.145)

1.073 (0.972, 1.185)

0.936 (0.912, 0.961)

1.138 (1.032, 1.254)

1095

0.997 (0.994, 1.000)

0.848 (0.793, 0.908)

1.055 (0.963, 1.155)

1.122 (1.022, 1.231)

1.111 (1.008, 1.224)

0.934 (0.910, 0.958)

1.082 (0.983, 1.190)

1460

0.999 (0.995, 1.002)

0.904 (0.842, 0.971)

1.029 (0.935, 1.132)

1.062 (0.963, 1.171)

1.074 (0.970, 1.189)

0.927 (0.902, 0.952)

1.088 (0.984, 1.203)

DM

DM + CKD

365

0.989 (0.986, 0.992)

0.944 (0.879, 1.013)

1.258 (1.143, 1.384)

1.156 (1.049, 1.274)

1.275 (1.152, 1.411)

0.941 (0.916, 0.967)

0.974 (0.882, 1.076)

730

0.990 (0.987, 0.993)

0.978 (0.916, 1.043)

1.241 (1.138, 1.354)

1.143 (1.046, 1.249)

1.214 (1.107, 1.332)

0.938 (0.915, 0.961)

0.996 (0.909, 1.091)

1095

0.991 (0.988, 0.994)

0.972 (0.911, 1.037)

1.241 (1.137, 1.353)

1.160 (1.062, 1.268)

1.219 (1.111, 1.337)

0.942 (0.919, 0.965)

0.992 (0.905, 1.086)

1460

0.992 (0.989, 0.996)

0.951 (0.888, 1.018)

1.234 (1.125, 1.354)

1.161 (1.056, 1.276)

1.217 (1.103, 1.342)

0.947 (0.922, 0.972)

1.042 (0.946, 1.148)

IHD

DM + IHD

365

0.996 (0.992, 1.000)

0.750 (0.694, 0.810)

1.021 (0.920, 1.134)

1.167 (1.049, 1.299)

1.102 (0.986, 1.232)

0.956 (0.928, 0.984)

1.064 (0.953, 1.187)

730

0.995 (0.992, 0.999)

0.802 (0.747, 0.862)

1.056 (0.959, 1.163)

1.140 (1.033, 1.258)

1.073 (0.968, 1.189)

0.960 (0.934, 0.987)

1.050 (0.949, 1.162)

1095

0.996 (0.993, 0.999)

0.805 (0.749, 0.864)

1.075 (0.977, 1.184)

1.142 (1.035, 1.259)

1.046 (0.945, 1.159)

0.956 (0.930, 0.982)

1.111 (1.005, 1.228)

1460

0.997 (0.994, 1.001)

0.789 (0.732, 0.850)

1.085 (0.982, 1.199)

1.150 (1.038, 1.274)

1.087 (0.977, 1.209)

0.949 (0.922, 0.976)

1.111 (1.000, 1.234)

IHD

IHD + CKD

365

1.022 (1.018, 1.026)

0.797 (0.736, 0.863)

0.970 (0.871, 1.079)

0.908 (0.814, 1.013)

0.999 (0.891, 1.119)

1.056 (1.024, 1.088)

1.234 (1.103, 1.380)

730

1.022 (1.019, 1.026)

0.813 (0.755, 0.875)

0.924 (0.836, 1.020)

0.884 (0.799, 0.978)

0.964 (0.867, 1.071)

1.039 (1.010, 1.069)

1.239 (1.117, 1.374)

1095

1.022 (1.019, 1.026)

0.813 (0.757, 0.875)

0.951 (0.863, 1.049)

0.890 (0.805, 0.983)

1.004 (0.905, 1.114)

1.028 (1.000, 1.057)

1.166 (1.052, 1.291)

1460

1.022 (1.018, 1.025)

0.807 (0.748, 0.871)

0.922 (0.832, 1.022)

0.864 (0.778, 0.960)

1.012 (0.907, 1.129)

1.018 (0.988, 1.048)

1.131 (1.016, 1.260)

CKD

DM + CKD

365

0.987 (0.982, 0.991)

0.876 (0.797, 0.963)

1.420 (1.251, 1.612)

1.217 (1.069, 1.385)

1.404 (1.227, 1.606)

0.993 (0.957, 1.029)

0.971 (0.850, 1.109)

730

0.989 (0.985, 0.993)

0.911 (0.835, 0.993)

1.415 (1.259, 1.591)

1.230 (1.092, 1.386)

1.425 (1.258, 1.613)

0.983 (0.951, 1.016)

0.942 (0.834, 1.064)

1095

0.989 (0.985, 0.993)

0.941 (0.862, 1.027)

1.402 (1.246, 1.576)

1.211 (1.074, 1.365)

1.389 (1.226, 1.574)

0.964 (0.932, 0.997)

0.911 (0.806, 1.031)

1460

0.990 (0.986, 0.994)

0.920 (0.841, 1.006)

1.390 (1.232, 1.567)

1.254 (1.109, 1.418)

1.404 (1.236, 1.596)

0.962 (0.929, 0.995)

0.916 (0.808, 1.038)

CKD

IHD + CKD

365

1.014 (1.009, 1.018)

0.832 (0.755, 0.917)

0.972 (0.853, 1.109)

0.879 (0.768, 1.005)

0.954 (0.829, 1.096)

1.052 (1.014, 1.092)

1.131 (0.986, 1.298)

730

1.013 (1.009, 1.017)

0.880 (0.807, 0.959)

0.987 (0.879, 1.108)

0.893 (0.793, 1.005)

0.944 (0.835, 1.068)

1.039 (1.005, 1.074)

1.101 (0.975, 1.242)

1095

1.013 (1.009, 1.017)

0.938 (0.861, 1.021)

0.990 (0.883, 1.110)

0.860 (0.765, 0.966)

0.917 (0.813, 1.036)

1.037 (1.004, 1.071)

1.046 (0.928, 1.178)

1460

1.014 (1.010, 1.019)

0.960 (0.878, 1.050)

0.964 (0.855, 1.087)

0.900 (0.796, 1.018)

0.936 (0.823, 1.063)

1.023 (0.989, 1.059)

1.111 (0.980, 1.260)

DM + IHD

DM + IHD + CKD

365

1.000 (0.993, 1.006)

0.674 (0.583, 0.779)

0.922 (0.758, 1.121)

0.974 (0.798, 1.190)

1.036 (0.841, 1.275)

0.970 (0.917, 1.025)

1.353 (1.103, 1.660)

730

0.998 (0.992, 1.003)

0.713 (0.634, 0.802)

1.002 (0.856, 1.173)

1.007 (0.857, 1.183)

1.129 (0.954, 1.335)

0.961 (0.919, 1.005)

1.354 (1.148, 1.597)

1095

0.996 (0.991, 1.001)

0.737 (0.663, 0.820)

1.078 (0.934, 1.244)

1.067 (0.922, 1.235)

1.136 (0.976, 1.323)

0.954 (0.916, 0.994)

1.241 (1.068, 1.441)

1460

0.999 (0.994, 1.004)

0.731 (0.660, 0.810)

1.089 (0.949, 1.250)

1.070 (0.930, 1.232)

1.154 (0.997, 1.336)

0.950 (0.913, 0.988)

1.256 (1.087, 1.451)

DM + CKD

DM + IHD + CKD

365

0.980 (0.973, 0.987)

0.830 (0.715, 0.964)

1.570 (1.283, 1.920)

1.206 (0.982, 1.482)

1.236 (0.998, 1.531)

0.966 (0.912, 1.023)

1.017 (0.824, 1.255)

730

0.982 (0.977, 0.988)

0.800 (0.711, 0.900)

1.506 (1.285, 1.765)

1.161 (0.987, 1.365)

1.347 (1.138, 1.594)

0.962 (0.919, 1.006)

1.026 (0.869, 1.211)

1095

0.984 (0.979, 0.989)

0.813 (0.731, 0.904)

1.444 (1.252, 1.666)

1.158 (1.000, 1.340)

1.334 (1.146, 1.553)

0.947 (0.909, 0.986)

0.981 (0.845, 1.140)

1460

0.985 (0.980, 0.990)

0.835 (0.752, 0.927)

1.450 (1.260, 1.669)

1.218 (1.055, 1.406)

1.404 (1.209, 1.630)

0.941 (0.904, 0.979)

0.979 (0.845, 1.134)

IHD + CKD

DM + IHD + CKD

365

1.005 (0.996, 1.014)

0.677 (0.558, 0.822)

1.367 (1.053, 1.775)

1.242 (0.951, 1.621)

1.296 (0.982, 1.711)

0.981 (0.911, 1.057)

1.307 (0.995, 1.717)

730

1.008 (1.000, 1.015)

0.635 (0.543, 0.742)

1.277 (1.034, 1.576)

1.080 (0.871, 1.340)

1.273 (1.017, 1.593)

0.983 (0.926, 1.044)

1.408 (1.130, 1.756)

1095

1.006 (0.999, 1.012)

0.678 (0.589, 0.780)

1.294 (1.071, 1.563)

1.049 (0.865, 1.272)

1.188 (0.972, 1.451)

0.980 (0.929, 1.034)

1.287 (1.057, 1.568)

1460

1.006 (0.999, 1.012)

0.691 (0.602, 0.792)

1.242 (1.033, 1.493)

1.066 (0.883, 1.286)

1.172 (0.963, 1.426)

0.976 (0.926, 1.029)

1.230 (1.014, 1.491)

DM

Death

365

1.007 (1.003, 1.011)

0.879 (0.809, 0.956)

1.144 (1.022, 1.280)

1.074 (0.957, 1.204)

1.138 (1.010, 1.283)

1.131 (1.096, 1.168)

1.097 (0.975, 1.233)

730

1.009 (1.004, 1.014)

0.895 (0.811, 0.988)

1.200 (1.050, 1.371)

1.016 (0.886, 1.163)

1.094 (0.950, 1.261)

1.136 (1.094, 1.180)

1.266 (1.102, 1.455)

1095

1.011 (1.006, 1.017)

0.913 (0.819, 1.019)

1.209 (1.043, 1.401)

1.025 (0.881, 1.192)

1.120 (0.957, 1.310)

1.125 (1.079, 1.173)

1.319 (1.131, 1.540)

1460

1.014 (1.008, 1.021)

0.949 (0.835, 1.080)

1.145 (0.963, 1.361)

0.966 (0.810, 1.153)

1.039 (0.865, 1.249)

1.091 (1.039, 1.146)

1.305 (1.089, 1.565)

IHD

Death

365

1.030 (1.026, 1.034)

0.880 (0.810, 0.957)

0.808 (0.722, 0.904)

0.745 (0.664, 0.835)

0.885 (0.786, 0.997)

1.204 (1.166, 1.243)

1.220 (1.085, 1.372)

730

1.029 (1.025, 1.033)

0.885 (0.818, 0.958)

0.797 (0.716, 0.887)

0.731 (0.655, 0.815)

0.830 (0.741, 0.929)

1.195 (1.159, 1.232)

1.300 (1.163, 1.453)

1095

1.030 (1.026, 1.034)

0.892 (0.825, 0.964)

0.819 (0.737, 0.910)

0.729 (0.655, 0.811)

0.807 (0.722, 0.902)

1.183 (1.148, 1.219)

1.381 (1.238, 1.541)

1460

1.031 (1.027, 1.035)

0.902 (0.827, 0.982)

0.864 (0.770, 0.970)

0.758 (0.674, 0.853)

0.825 (0.729, 0.932)

1.161 (1.123, 1.200)

1.362 (1.207, 1.537)

CKD

Death

365

1.027 (1.024, 1.031)

0.866 (0.803, 0.933)

0.958 (0.866, 1.060)

0.916 (0.826, 1.015)

0.928 (0.833, 1.033)

1.341 (1.303, 1.380)

1.411 (1.269, 1.568)

730

1.028 (1.025, 1.031)

0.872 (0.812, 0.936)

0.934 (0.849, 1.028)

0.851 (0.772, 0.937)

0.899 (0.813, 0.995)

1.313 (1.278, 1.349)

1.461 (1.323, 1.614)

1095

1.030 (1.026, 1.034)

0.915 (0.852, 0.984)

0.931 (0.845, 1.026)

0.859 (0.778, 0.949)

0.920 (0.829, 1.020)

1.286 (1.251, 1.322)

1.473 (1.331, 1.631)

1460

1.032 (1.028, 1.036)

0.932 (0.858, 1.013)

0.910 (0.813, 1.017)

0.915 (0.816, 1.026)

0.882 (0.783, 0.994)

1.243 (1.204, 1.283)

1.508 (1.341, 1.695)

DM + IHD

Death

365

1.018 (1.007, 1.030)

0.676 (0.530, 0.862)

1.107 (0.798, 1.536)

0.908 (0.650, 1.269)

1.015 (0.717, 1.438)

1.070 (0.974, 1.175)

1.053 (0.748, 1.484)

730

1.018 (1.009, 1.027)

0.712 (0.588, 0.862)

1.094 (0.846, 1.415)

1.051 (0.808, 1.366)

1.012 (0.770, 1.330)

1.071 (0.995, 1.153)

1.051 (0.803, 1.376)

1095

1.016 (1.008, 1.024)

0.742 (0.628, 0.877)

1.135 (0.907, 1.422)

1.048 (0.833, 1.319)

1.016 (0.800, 1.290)

1.065 (0.999, 1.135)

1.091 (0.863, 1.381)

1460

1.018 (1.011, 1.025)

0.715 (0.614, 0.832)

1.066 (0.869, 1.308)

0.984 (0.798, 1.212)

1.020 (0.820, 1.267)

1.032 (0.973, 1.093)

1.299 (1.049, 1.608)

DM + CKD

Death

365

1.008 (0.999, 1.017)

0.814 (0.671, 0.986)

1.409 (1.087, 1.825)

1.209 (0.928, 1.575)

1.215 (0.922, 1.600)

1.110 (1.031, 1.195)

0.820 (0.626, 1.075)

730

1.010 (1.003, 1.018)

0.833 (0.711, 0.975)

1.311 (1.061, 1.621)

1.166 (0.939, 1.448)

1.202 (0.959, 1.505)

1.085 (1.022, 1.153)

0.970 (0.777, 1.210)

1095

1.009 (1.003, 1.016)

0.819 (0.713, 0.941)

1.293 (1.072, 1.559)

1.117 (0.922, 1.352)

1.165 (0.955, 1.422)

1.067 (1.012, 1.126)

0.970 (0.798, 1.180)

1460

1.009 (1.003, 1.015)

0.834 (0.729, 0.953)

1.253 (1.047, 1.501)

1.158 (0.964, 1.392)

1.195 (0.987, 1.447)

1.050 (0.998, 1.106)

0.970 (0.803, 1.171)

IHD + CKD

Death

365

1.031 (1.026, 1.037)

0.862 (0.772, 0.962)

0.973 (0.839, 1.128)

0.837 (0.719, 0.973)

0.970 (0.829, 1.135)

1.166 (1.117, 1.216)

1.363 (1.167, 1.591)

730

1.031 (1.026, 1.035)

0.840 (0.766, 0.921)

0.987 (0.872, 1.117)

0.850 (0.749, 0.965)

0.978 (0.857, 1.116)

1.149 (1.109, 1.190)

1.347 (1.183, 1.534)

1095

1.031 (1.027, 1.035)

0.849 (0.782, 0.923)

0.977 (0.874, 1.093)

0.853 (0.761, 0.956)

0.973 (0.864, 1.096)

1.138 (1.102, 1.175)

1.328 (1.181, 1.492)

1460

1.031 (1.027, 1.035)

0.840 (0.775, 0.911)

0.970 (0.869, 1.082)

0.901 (0.806, 1.007)

0.997 (0.888, 1.120)

1.131 (1.097, 1.167)

1.350 (1.204, 1.513)

DM + IHD + CKD

Death

365

1.015 (1.007, 1.023)

0.610 (0.515, 0.723)

1.474 (1.172, 1.853)

1.436 (1.136, 1.815)

1.544 (1.210, 1.970)

1.032 (0.968, 1.086)

1.196 (0.941, 1.520)

730

1.013 (1.006, 1.020)

0.642 (0.558, 0.738)

1.402 (1.161, 1.692)

1.256 (1.036, 1.522)

1.433 (1.173, 1.751)

1.024 (0.974, 1.078)

1.189 (0.976, 1.447)

1095

1.012 (1.006, 1.018)

0.688 (0.609, 0.777)

1.353 (1.148, 1.595)

1.202 (1.017, 1.422)

1.439 (1.209, 1.713)

1.027 (0.989, 1.067)

1.196 (1.007, 1.420)

1460

1.011 (1.005, 1.016)

0.704 (0.628, 0.788)

1.443 (1.238, 1.682)

1.309 (1.119, 1.530)

1.481 (1.259, 1.744)

1.041 (0.995, 1.087)

1.202 (1.024, 1.411)