Table 2 Age standardised risk factor summary
From: Breast cancer risk in a screening cohort of Asian and white British/Irish women from Manchester UK
Risk factor | Mean (standard deviation) or Percentage (%)a | Difference (95%CI) | P | |
|---|---|---|---|---|
Asian | White | (Asian – White) | ||
Puberty | ||||
Age at menarche (y) | 13.3 (1.6) | 12.9 (1.6) | 0.37 (0.2 to 0.5) | < 0.001 |
Height and weight | ||||
Body mass index (kg/m2) | 26.5 (5.2) | 27.5 (5.5) | −0.97 (−1.4 to − 0.6) | < 0.001 |
Weight (kg) | 65.5 (13.4) | 71.6 (14.8) | −6.10 (−7.1 to −5.1) | < 0.001 |
Height (m) | 1.57 (0.07) | 1.62 (0.07) | −0.045 (− 0.051 to − 0.039) | < 0.001 |
Reproductive factors | ||||
Nulliparous | 9.7% | 13.0% | −3.39% (−5.5 to −1.0%) | 0.003 |
Age first child(y) | 24.7 (5.2) | 24.4 (5.1) | 0.36 (−0.08 to 0.8) | 0.12 |
Children (n) | 2.7 (1.7) | 2.0 (1.2) | 0.65 (0.5 to 0.8) | < 0.001 |
Four or more (y) | 26.7% | 10.0% | 16.73% (13.1 to 20.4%) | < 0.001 |
1st <17y (y) | 1.6% | 1.6% | 0.00% (−0.9 to 1.1%) | 0.9 |
Menopausal status | ||||
Pre-menopausal | 14.5% | 14.4% | 0.15% (−1.6 to 1.9%) | 0.9 |
Peri-menopausal | 13.4% | 16.6% | −3.17% (−5.2 to −1.1%) | 0.002 |
Post-menopausal | 72.0% | 69.0% | 3.01% (0.8 to 5.1%) | 0.007 |
Age menopause (post-menopausal) | 47.6 (5.7) | 46.8 (5.9) | 0.80 (0.3 to 1.3) | 0.002 |
Hormone therapy (ever) | 20.3% | 38.3% | −18.02% (−21.1 to − 14.8%) | < 0.001 |
Genetic disposition | ||||
1 or more affected first-degree relatives | 10.4% | 12.1% | −1.69% (−4.1 to 0.8%) | 0.18 |
Mammographic density | ||||
Percent density (%) | 30.2 (18.1) | 27.7 (17.3) | 2.52 (1.1 to 4.0) | < 0.001 |
Percent density (%, BMI adjusted) | 28.6b | 26.8b | 1.83 (0.04 to 3.3) | 0.011 |
Overall 10-year risk (Tyrer-Cuzick model) | ||||
Mean (standard deviation) | 2.67 (1.39) | 3.07 (1.49) | −0.405 (−0.53 to −0.26) | < 0.001 |
Percentage ≥ 5% | 6.7% | 9.9% | −3.28% (−5.3 to −1.1%) | 0.003 |
Percentage < 2% | 32.6% | 18.9% | 13.73% (10.2 to 17.3%) | < 0.001 |
Other risk factors | ||||
Adult Weight gain (% change weight since 20y) | 28.7 (22.2) | 24.3 (21.3) | 4.41 (3.4 to 6.0) | < 0.001 |
Physical Activity (y/n) | 49.9% | 72.2% | −22.29% (−26.7 to −18.0%) | < 0.001 |
Physical activity(> 4 h/wk) | 58.0% | 62.7% | −4.75% (−9.9 to 0.4%) | 0.067 |
Drink alcohol (any) | 18.6% | 73.0% | −54.36% (−57.8 to − 50.8%) | < 0.001 |