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Table 2 Multivariate Cox’s proportional hazards regression model each evidence-based medications

From: The impact of age on the implementation of evidence-based medications in patients with coronary artery disease and its prognostic significance: a retrospective cohort study

  

< 60 years old

60–75 years old

≥75 years old

Medicines

Mortality

Unadjusted HR (95% CI)

Adjusted HR (98% CI)

Propensity score analysis unadjusted HR (98% CI)

Unadjusted HR (96% CI)

Adjusted HR (99% CI)

Propensity score analysis unadjusted HR (98% CI)

Unadjusted HR (97% CI)

Adjusted HR (100% CI)

Propensity score analysis unadjusted HR (98% CI)

Aspirin

All-cause death

0.13 (0.06–0.27)

0.12 (0.05–0.25)

0.19 (0.04–0.86)

0.16 (0.11–0.22)

0.17 (0.11–0.24)

0.17 (0.08–0.36)

0.21 (0.13–0.32)

0.22 (0.14–0.34)

0.21 (0.09–0.45)

 

CV death

0.07 (0.03–0.15)

0.06 (0.02–0.15)

0.09 (0.01–0.74)

0.11 (0.07–0.18)

0.12 (0.07–0.19)

0.16 (0.06–0.41)

0.17 (0.09–0.30)

0.17 (0.09–0.31)

0.26 (0.10–0.66)

Clopidogrel

All-cause death

0.16 (0.08–0.32)

0.14 (0.07–0.28)

0.26 (0.07–0.94)

0.25 (0.18–0.36)

0.26 (0.18–0.38)

0.20 (0.10–0.40)

0.30 (0.19–0.47)

0.30 (0.19–0.47)

0.42 (0.23–0.77)

 

CV death

0.11 (0.05–0.27)

0.11 (0.05–0.27)

0.11 (0.01–0.85)

0.14 (0.09–0.22)

0.15 (0.09–0.23)

0.14 (0.05–0.36)

0.27 (0.15–0.48)

0.26 (0.14–0.48)

0.42 (0.19–0.95)

Dual-antiplatelet

All-cause death

0.18 (0.09–0.36)

0.15 (0.07–0.30)

0.06 (0.01–0.47)

0.26 (0.18–0.37)

0.27 (0.19–0.38)

0.18 (0.09–0.36)

0.33 (0.21–0.51)

0.34 (0.22–0.53)

0.38 (0.20–0.69)

 

CV death

0.12 (0.05–0.29)

0.12 (0.05–0.28)

0.01 (0–1.53)

0.17 (0.11–0.27)

0.17 (0.11–0.28)

0.16 (0.07–0.38)

0.31 (0.17–0.55)

0.31 (0.17–0.56)

0.42 (0.19–0.92)

Statins

All-cause death

0.18 (0.08–0.38)

0.16 (0.08–0.35)

0.43 (0.15–1.24)

0.29 (0.20–0.41)

0.30 (0.21–0.43)

0.08 (0.03–0.23)

0.20 (0.13–0.31)

0.20 (0.12–0.31)

0.31 (0.15–0.61)

 

CV death

0.10 (0.04–0.25)

0.10 (0.04–0.24)

0.29 (0.08–1.05)

0.22 (0.14–0.35)

0.23 (0.14–0.37)

0.10 (0.03–0.32)

0.15 (0.09–0.28)

0.15 (0.08–0.27)

0.31 (0.13–0.75)

ACEIs or ARBs

All-cause death

0.86 (0.43–1.74)

0.89 (0.44–1.80)

0.83 (0.42–1.64)

0.48 (0.34–0.68)

0.50 (0.35–0.70)

0.43 (0.29–0.64)

0.48 (0.31–0.74)

0.54 (0.35–0.84)

0.44 (0.27–0.70)

 

CV death

0.54 (0.22–1.35)

0.54 (0.22–1.34)

0.47 (0.19–1.14)

0.41 (0.25–0.65)

0.42 (0.26–0.68)

0.31 (0.17–0.55)

0.41 (0.23–0.73)

0.45 (0.25–0.83)

0.35 (0.18–0.69)

Beta-blockers

All-cause death

0.49 (0.25–0.97)

0.50 (0.25–1.00)

0.60 (0.27–1.32)

0.34 (0.24–0.47)

0.35 (0.25–0.48)

0.36 (0.24–0.55)

0.65 (0.43–0.99)

0.65 (0.42–1.00)

0.63 (0.40–0.99)

 

CV death

0.33 (0.14–0.76)

0.35 (0.15–0.83)

0.37 (0.13–1.03)

0.31 (0.19–0.48)

0.32 (0.20–0.51)

0.27 (0.14–0.50)

0.44 (0.25–0.78)

0.44 (0.25–0.80)

0.34 (0.17–0.67)

  1. Abbreviations: CAD Coronary artery disease, CI Confidence interval, CV Death: cardiovascular death, HR Hazard ratio, LDL-C Low-density lipoprotein-cholesterol, STEMI: ST-segment elevated myocardial infarction.Adjusted factor: sex, history of hypertension, history of diabetes mellitus, and history of heart failure, history of dyslipidemia, smoking status, eGFR and hepatic enzymes
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