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Table 1 Expressions 1 and 2 solved for the individual relative risk (IRR) and the high-risk proportion q, according to the familial relative risks (FRRs) given one (FRR1) and two (FRR2) affected relatives

From: The surprising implications of familial association in disease risk

Cancer Familial relationship studied FRR 1 FRR 2 IRR q
Testicular cancer [20] Brothers 5.88 21.71 30.6 0.010
Prostate cancer [51] Brothers 2.96 7.71 12.2 0.027
Colorectal cancer [52] Siblings 2.25 4.25 a 7.4 0.067
Melanoma [53] FDRs 1.9 4.7 a 8.2 0.025
Breast cancer [25] Women FDRs 1.80 2.93 5.2 0.10
Hodgkin’s lymphoma [54] FDRs 6 13 a 22.6 0.030
Non-medullary thyroid cancer [55] FDRs 3.1 23.2 a 34.2 0.0022
  1. Abbreviations: FRR: Familial relative risk; IRR: Individual relative risk; FDR: First degree relative
  2. a ≥ 2 siblings/FDRs is used in the reference
  3. Estimates for FRR1 and FRR2 are taken from the indicated reference (the level of accuracy given in the reference is used)