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Table 2 Published studies on acute coronary syndrome in PLWH in sub-Saharan Africa

From: The association between HIV and atherosclerotic cardiovascular disease in sub-Saharan Africa: a systematic review

Study
(location, dates)
Study Design N = Age (years)a ART-status Findings
Becker et al. [101]
(SA, 2004-08)
Prospective case-control ACS + PLWH: 30
ACS + HIV-: 30
43 ± 7 54 ± 13 100% ART-naïve • Traditional risk factors more prevalent in HIV-, except for smoking
• PLWH more likely to have single vessel disease and greater thrombus burden
• PLWH more likely to have MACE and need TLR at follow-up
Becker et al. [103]
(SA, 2004-08)
Same study population as above • PLWH with ACS more likely to have lower protein C and higher Factor VIII, Anti-cardiolipin IgG and Anti-prothrombin IgG
Becker et al. [104]
(SA, 2004-08)
Prospective case-control ACS-PLWH: 30
ACS + PLWH: 30
ACS + HIV-: 30
41 ± 8
43 ± 7
54 ± 13
100% ART-naïve • PLWH are more likely to have anti-phospholipid antibodies but this is not associated with ACS
Sliwa et al. [24]
(SA, 2006-08)
Cohort PLWH: 518 39 ± 13 46% ART-naïve
54% on ART
• 170 (32.8%) were new HIV diagnoses
• 14 (2.7%) were admitted with ACS and 18 (3.5%) with cerebrovascular disease
Redman et al. [105]
(SA, 2008-11)
Prospective cohort of vascular surgery patients PLWH: 73
HIV-: 152
41 ± 10
56 ± 13
68% ART-naïve
23% on ART
• Lower RCRI score among PLWH
• No difference in 30 day outcomes (13% vs 15%), even though PLWH were younger
  1. amean ± SD or median (IQR)
  2. PLWH people living with HIV, SA South Africa, ACS acute coronary syndrome, ART antiretroviral therapy, MACE major adverse cardiovascular events, TLR target lesion revascularization, RCRI Revised Cardiac Risk Index
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