Fig. 2

Schematic description of the planned register linkage of the MATEX cohort. The Matex cohort is recruited from the MBR with other registers for the two proof-of-concept case studies. Registers are linked via mother’s personal identification number (PIN) (for the Population Register) or the child’s PIN (all other registers). The main exposures targeted will be maternal smoking and air pollution. The main endpoints will be birth outcomes, childhood asthma, childhood cancer and congenital anomalies