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Table 5 Schedule for nicotine pharmacokinetic assessment

From: A randomised, controlled, two-Centre open-label study in healthy Japanese subjects to evaluate the effect on biomarkers of exposure of switching from a conventional cigarette to a tobacco heating product

Day

Start of Procedure

Procedure

7

19:00–20:00a

Start of product use abstinence

20:00–22:00

Snack

8

06:00–08:00b

Light breakfast / snack

08:00–11:00

Start of pharmacokinetic assessment period

• Pharmacokinetic blood draws

• Product satisfaction questionnaire

12:00–15:00

End of pharmacokinetic assessment period

  1. aFollowing completion of final 24-h urine collection period. bLight breakfast / snack will be completed at least 1 h prior to the start of the pharmacokinetic assessment period
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BMC Public Health

ISSN: 1471-2458

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