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Table 3 Prevalence of HBsAg seropositivity in previous studies (n = 12) and the current study in Madagascar

From: Prevalence of chronic hepatitis B virus infection and infrastructure for its diagnosis in Madagascar: implication for the WHO’s elimination strategy

Author Year published HBsAg assay Province Study population Male (%) Age No. tested No. positive Prevalence of HBsAg
Oddou [11] 1972 Immunodifusion Antananarivo Blood donors N/R N/R 578 17 2.9%
Capdevieille [30] 1979 PHA Antananarivo Blood donors N/R N/R 4000 217 5.4%
Patients with liver disease N/R N/R 100 43 43.0%
Ravaoarinoro [14] 1985 ELISA Antananarivo Blood donors 87.2% 19–63 172 4 2.3%
Patients 55.4% 1–65 186 8 4.3%
Mathiot [31] 1987 Electrosyneresis Antananarivo High-risk populationa 50.0% N/R 178 7 3.9%
Genin [32] 1988 ELISA Toamasina High-risk populationa N/R Mean 27 (14–66) 367 65 17.7%
Antsiranana High-risk populationa 278 26 9.4%
Toliara High-risk populationa 258 46 17.8%
Mahajanga High-risk populationa 228 41 18.0%
Rasamindrakotroka [33] 1993 ELISA Antananarivo Blood donors 83.9% Range: 18–60 1629 77 4.7%
Morvan [10] 1994 ELISA Antananarivo General population 52.9% Mean 22.0 (1–86) 456 86 18.9%
Toliara General population 48.2% Mean 21.1 (1–62) 197 60 30.5%
Boisier [7] 1996 ELISA Antananarivo General population 45.4% Range: 1–94 243 13 5.3%
Toamasina General population 678 176 26.0%
Migliani [9] 2000 ELISA Mahajanga General population 41.9% Median 22.5 (2–93) 654 93 14.2%
Dupinay [8] 2010 ELISA Antsiranana General population 53.5% Median 29 (15–55) 563 48 8.5%
Randriamanantany [13] 2011 IC Antananarivo Blood donors 80.5% Mean 33.3 ± 10.4 47,597 1810 3.8%
Randriamahazo [12] 2015 IC Antananarivo Pregnant women 0% Mean 26.5 (14–44) 1050 20 1.9%
Andriamandimby 2016 ELISA All provinces General population 50.3% Mean 37.7(± 14.4) 1778 141 6.9%b
  1. aHigh-risk population includes prostitutes, prisoners and men who have sex with men
  2. bWeighted
  3. Abbreviations: PHA passive hemagglutination, ELISA enzyme-linked immunosorbent assay, IC immunochromatography, N/R not reported
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