Prevalence of chronic hepatitis B virus infection and infrastructure for its diagnosis in Madagascar: implication for the WHO’s elimination strategy

Andriamandimby, Soa Fy; Olive, Marie-Marie; Shimakawa, Yusuke; Rakotomanana, Fanjasoa; Razanajatovo, Iony Manitra; Andrianinarivomanana, Tsarasoa Malala; Ravalohery, Jean-Pierre; Andriamamonjy, Seta; Rogier, Christophe; Héraud, Jean-Michel

doi:10.1186/s12889-017-4630-z

Table 3 Prevalence of HBsAg seropositivity in previous studies (n = 12) and the current study in Madagascar

From: Prevalence of chronic hepatitis B virus infection and infrastructure for its diagnosis in Madagascar: implication for the WHO’s elimination strategy

Author	Year published	HBsAg assay	Province	Study population	Male (%)	Age	No. tested	No. positive	Prevalence of HBsAg
Oddou [11]	1972	Immunodifusion	Antananarivo	Blood donors	N/R	N/R	578	17	2.9%
Capdevieille [30]	1979	PHA	Antananarivo	Blood donors	N/R	N/R	4000	217	5.4%
Capdevieille [30]	1979	PHA	Antananarivo	Patients with liver disease	N/R	N/R	100	43	43.0%
Ravaoarinoro [14]	1985	ELISA	Antananarivo	Blood donors	87.2%	19–63	172	4	2.3%
Ravaoarinoro [14]	1985	ELISA	Antananarivo	Patients	55.4%	1–65	186	8	4.3%
Mathiot [31]	1987	Electrosyneresis	Antananarivo	High-risk population^a	50.0%	N/R	178	7	3.9%
Genin [32]	1988	ELISA	Toamasina	High-risk population^a	N/R	Mean 27 (14–66)	367	65	17.7%
			Antsiranana	High-risk population^a			278	26	9.4%
			Toliara	High-risk population^a			258	46	17.8%
			Mahajanga	High-risk population^a			228	41	18.0%
Rasamindrakotroka [33]	1993	ELISA	Antananarivo	Blood donors	83.9%	Range: 18–60	1629	77	4.7%
Morvan [10]	1994	ELISA	Antananarivo	General population	52.9%	Mean 22.0 (1–86)	456	86	18.9%
Morvan [10]	1994	ELISA	Toliara	General population	48.2%	Mean 21.1 (1–62)	197	60	30.5%
Boisier [7]	1996	ELISA	Antananarivo	General population	45.4%	Range: 1–94	243	13	5.3%
Boisier [7]	1996	ELISA	Toamasina	General population	45.4%	Range: 1–94	678	176	26.0%
Migliani [9]	2000	ELISA	Mahajanga	General population	41.9%	Median 22.5 (2–93)	654	93	14.2%
Dupinay [8]	2010	ELISA	Antsiranana	General population	53.5%	Median 29 (15–55)	563	48	8.5%
Randriamanantany [13]	2011	IC	Antananarivo	Blood donors	80.5%	Mean 33.3 ± 10.4	47,597	1810	3.8%
Randriamahazo [12]	2015	IC	Antananarivo	Pregnant women	0%	Mean 26.5 (14–44)	1050	20	1.9%
Andriamandimby	2016	ELISA	All provinces	General population	50.3%	Mean 37.7(± 14.4)	1778	141	6.9%^b

^aHigh-risk population includes prostitutes, prisoners and men who have sex with men
^bWeighted
Abbreviations: PHA passive hemagglutination, ELISA enzyme-linked immunosorbent assay, IC immunochromatography, N/R not reported

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ISSN: 1471-2458

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