Table 2 Screening strategies

Kulasingam 2003 [27]

Sanders 2003 [28]

Goldie 2004 [29]

Taira 2004 [32]

Kulasingam 2007 [39]

Primary screening

CC

CC

CC/LBC

CC

CC

  Compliance

100% (50–100%)

71% (60–80%)

100%

-

By age

Triage

CC

-

HPV DNA

-

-

Cytology

  Sens/Spe

0.556(0.51–0.95)/ 0.957(0.80–0.97)

0.51(0.40–0.80)/ 0.97(0.95–0.98)

0.66(0.34–0.86)/

0.97(0.88–0.99)

-

0.80(0.48–0.80)/

0.95(0.90–0.99)

Price

$45 ($61–$75)

$81($61–$101)

$15–$51

($12–75)

$58($29–$86)

HPV DNA

  Sens/Spe

-

-

-

-

-

  Price

$49 ($30–$200)

Goldhaber-Fiebert 2008 [33]

Kim 2008 [31]

Coupe, de Melker 2009 [35]

Coupe, van Ginkel 2009 [36]

Kim 2009 [30]

Primary screening

CC/HPV DNA

CC

CC/HPV DNA

CC

CC

  Compliance

-

-

80%

80% (20/70%)

-

Triage

HPV DNA/CC

HPV DNA (3y)

HPV DNA/CC

-

HPV DNA

Cytology

  Sens/Spe

0.8(0.186–0.99)/0.95(0.87–0.996)

-

-

-

-

  Price

$30($6–$87)

HPV DNA

  Sens/Spe

0.83(0.70–0.85) / 0.93(0.79–0.94)

-

0.94/1

-

-

  Price

$55($14–$217)

Kim, Ortendahl 2009 [34]

Accetta 2010 [38]

Diaz 2010 [43]

Demarteau 2011 [41]

Burger 2012 [42]

Primary screening

CC/Combined

CC/HPV DNA

CC/Combined

CC

CC

  Compliance

53% 1y, 17% 2y, 11% 3y, 15% 5y

70.90%

-

60% 3y (48%,1y-72%,5y)

100%

Triage

HPV DNA

HPV DNA/CC

HPV DNA

-

HPV DNA

Cytology

  Sens/Spe

0.8/0.95

0.8/0.95

0.8/0.95

0.58–0.61 (0.46–0.73)

0.8/0.95

  Price

HPV DNA

  Sens/Spe

0.93/0.93

0.96/0.94

0.88/0.93

-

1/1

  Price

Coupe 2012 [37]

Tully 2012 [40]

Berkhof 2013 [44]

Primary screening

CC/HPV DNA

CC

CC/HPV DNA

  Compliance

80% (40%)

-

-

Triage

-/CC

-

-

Cytology

  Sens/Spe

-

0.58–0.85/0.962–0.974

-

  Price

€52.80

HPV DNA

  Sens/Spe

0.94/0.97

-

-/1

  Price

€65.6