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Table 2 Screening strategies

From: Systematic review of cost-effectiveness analyses for combinations of prevention strategies against human papillomavirus (HPV) infection: a general trend

  Kulasingam 2003 [27] Sanders 2003 [28] Goldie 2004 [29] Taira 2004 [32] Kulasingam 2007 [39]
Primary screening CC CC CC/LBC CC CC
Compliance 100% (50–100%) 71% (60–80%) 100% - By age
Triage CC - HPV DNA - -
Cytology      
Sens/Spe 0.556(0.51–0.95)/ 0.957(0.80–0.97) 0.51(0.40–0.80)/ 0.97(0.95–0.98) 0.66(0.34–0.86)/
0.97(0.88–0.99)
- 0.80(0.48–0.80)/
0.95(0.90–0.99)
Price $45 ($61–$75) $81($61–$101) $15–$51
($12–75)
  $58($29–$86)
HPV DNA      
Sens/Spe - - - - -
Price    $49 ($30–$200)   
  Goldhaber-Fiebert 2008 [33] Kim 2008 [31] Coupe, de Melker 2009 [35] Coupe, van Ginkel 2009 [36] Kim 2009 [30]
Primary screening CC/HPV DNA CC CC/HPV DNA CC CC
Compliance - - 80% 80% (20/70%) -
Triage HPV DNA/CC HPV DNA (3y) HPV DNA/CC - HPV DNA
Cytology      
Sens/Spe 0.8(0.186–0.99)/0.95(0.87–0.996) - - - -
Price $30($6–$87)     
HPV DNA      
Sens/Spe 0.83(0.70–0.85) / 0.93(0.79–0.94) - 0.94/1 - -
Price $55($14–$217)     
  Kim, Ortendahl 2009 [34] Accetta 2010 [38] Diaz 2010 [43] Demarteau 2011 [41] Burger 2012 [42]
Primary screening CC/Combined CC/HPV DNA CC/Combined CC CC
Compliance 53% 1y, 17% 2y, 11% 3y, 15% 5y 70.90% - 60% 3y (48%,1y-72%,5y) 100%
Triage HPV DNA HPV DNA/CC HPV DNA - HPV DNA
Cytology      
Sens/Spe 0.8/0.95 0.8/0.95 0.8/0.95 0.58–0.61 (0.46–0.73) 0.8/0.95
Price      
HPV DNA      
Sens/Spe 0.93/0.93 0.96/0.94 0.88/0.93 - 1/1
Price      
  Coupe 2012 [37] Tully 2012 [40] Berkhof 2013 [44]  
Primary screening CC/HPV DNA CC CC/HPV DNA
Compliance 80% (40%) - -
Triage -/CC - -
Cytology    
Sens/Spe - 0.58–0.85/0.962–0.974 -  
Price €52.80    
HPV DNA    
Sens/Spe 0.94/0.97 - -/1
Price €65.6   
  1. CC refers to the Pap smear test