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Table 3 Key events surrounding voluntary recalls of MoM

From: Halo and spillover effect illustrations for selected beneficial medical devices and drugs

Product Year Event
MoM Hip Implants 1930s MoM hip implants first used for resurfacing and total replacement
1950s MoP implant replaces early gen MoMs, lower early revision rates
1950s-1970s MoP revision rates favorable at 5 and 10 yrs. post-implantation
1970s-1980s Post ~ 15 years, MoP disintegrates, causes local inflammation, failure
1990s New gen MoMs in Europe; early revision rates comparable to MoP
2003 New MoMs sold in the US
2003 DePuy ASR XL Acetabular Hip System introduced to Europe
2005 DePuy ASR XL Acetabular Hip System introduced to US
2004- 2012 MoM Case reports: inflammation, nervous system and heart effects
2008 Zimmer Durom AS MoM withdrawn (US)
2008-2011 Australia and UK hip implant registries: increased rates of early revision for ASR XL Acetabular Hip System
2008-2011 Reported increased early revision rates (certain MoMs): 3 manufacturers remove devices from markets
2009 DePuy conducts a voluntary recall in Australia
2010 Worldwide recall of the DePuy ASR product
2012 Smith and Nephew withdraw R3 Acetabular System with R3 metal liners (US): reported elevated early revision rates in conjunction with the Birmingham Hip Resurfacing System
Post-recall Negative press articles and personal injury litigation ensue in the US
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